ENSG00000070614

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261797 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding protein_coding 25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 1.564202 1.754668 2.188369 0.9538317 2.1883689 0.3170368 0.07449583 0.07830000 0.06113333 -0.01716667 0.721347875 0.002725462 FALSE TRUE
ENST00000521752 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding processed_transcript 25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 3.529752 4.984308 3.875218 0.4787923 0.2346493 -0.3622895 0.11633333 0.20473333 0.10920000 -0.09553333 0.002725462 0.002725462 FALSE FALSE
ENST00000522491 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding protein_coding 25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 1.490837 1.188599 2.015602 0.3327451 0.4947422 0.7570017 0.05929583 0.04813333 0.05523333 0.00710000 0.840141706 0.002725462   FALSE
MSTRG.27165.3 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding   25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 6.330535 4.820583 8.945385 1.0495181 1.4030557 0.8905581 0.24651250 0.19580000 0.24666667 0.05086667 0.671852309 0.002725462 FALSE TRUE
MSTRG.27165.6 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding   25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 2.104700 2.146347 3.371042 1.1069763 0.6082829 0.6488782 0.07972917 0.07946667 0.09496667 0.01550000 0.783788887 0.002725462 TRUE TRUE
MSTRG.27165.7 ENSG00000070614 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDST1 protein_coding   25.85251 24.5087 35.81022 2.774516 3.119853 0.5468921 7.239992 6.974851 9.771954 0.7988995 1.0219506 0.4858934 0.28654583 0.28553333 0.27536667 -0.01016667 0.935513166 0.002725462 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000070614 E001 1.1737422 0.1004314050 9.964912e-01   5 150485572 150485730 159 + 0.320 0.327 0.050
ENSG00000070614 E002 7.9364927 0.0032158072 2.849442e-01 0.68755917 5 150485731 150485817 87 + 0.994 0.888 -0.401
ENSG00000070614 E003 46.5986003 0.0006652080 1.743139e-01 0.57210946 5 150485818 150485962 145 + 1.701 1.647 -0.184
ENSG00000070614 E004 37.8477528 0.0015347947 3.783865e-01 0.75894751 5 150485963 150485978 16 + 1.607 1.571 -0.124
ENSG00000070614 E005 36.7283241 0.0065148319 8.534212e-01 0.96366366 5 150485979 150485995 17 + 1.577 1.581 0.011
ENSG00000070614 E006 37.0594647 0.0056502798 6.799498e-01 0.90814373 5 150485996 150486003 8 + 1.587 1.576 -0.038
ENSG00000070614 E007 29.5472558 0.0010715173 9.040114e-01 0.97723922 5 150486004 150486023 20 + 1.482 1.490 0.028
ENSG00000070614 E008 3.0288990 0.0239210202 9.530119e-03 0.16952505 5 150486294 150486330 37 + 0.764 0.326 -2.104
ENSG00000070614 E009 6.8210477 0.0533649201 5.439477e-02 0.35690769 5 150486331 150486386 56 + 1.016 0.708 -1.191
ENSG00000070614 E010 6.4863002 0.0255681990 8.192068e-02 0.42179327 5 150486387 150486407 21 + 0.977 0.739 -0.919
ENSG00000070614 E011 0.1544607 0.0466661794 3.705658e-01   5 150497778 150497926 149 + 0.000 0.138 10.562
ENSG00000070614 E012 0.1544607 0.0466661794 3.705658e-01   5 150497927 150497979 53 + 0.000 0.138 10.562
ENSG00000070614 E013 0.0000000       5 150497980 150498239 260 +      
ENSG00000070614 E014 0.0000000       5 150507640 150507698 59 +      
ENSG00000070614 E015 0.1795728 0.0334470118 3.710742e-01   5 150508131 150508146 16 + 0.000 0.138 10.709
ENSG00000070614 E016 0.5231092 0.0211532404 4.944925e-02   5 150508147 150508226 80 + 0.000 0.327 12.486
ENSG00000070614 E017 3.0163012 0.0072057956 6.919972e-01 0.91239496 5 150518798 150518919 122 + 0.567 0.639 0.319
ENSG00000070614 E018 233.3645267 0.0003630513 4.907385e-02 0.34175873 5 150520868 150521248 381 + 2.379 2.347 -0.104
ENSG00000070614 E019 112.2420392 0.0002842214 6.246641e-01 0.88585773 5 150521249 150521323 75 + 2.049 2.049 0.001
ENSG00000070614 E020 154.2321820 0.0067660655 2.466581e-01 0.65213894 5 150521324 150521458 135 + 2.205 2.164 -0.138
ENSG00000070614 E021 240.6304250 0.0018085300 2.409402e-02 0.25474362 5 150521459 150521767 309 + 2.399 2.350 -0.163
ENSG00000070614 E022 392.5998806 0.0016710700 6.307214e-03 0.14059645 5 150527804 150528298 495 + 2.611 2.563 -0.160
ENSG00000070614 E023 189.8244745 0.0004829620 2.292766e-02 0.24968554 5 150532945 150533032 88 + 2.294 2.250 -0.149
ENSG00000070614 E024 232.1302057 0.0015661146 1.927610e-02 0.23193498 5 150534867 150535021 155 + 2.383 2.335 -0.162
ENSG00000070614 E025 8.3013554 0.0090524370 6.630712e-01 0.90151682 5 150535022 150535025 4 + 0.982 0.947 -0.128
ENSG00000070614 E026 237.0355715 0.0031664225 7.205269e-02 0.40003418 5 150535700 150535885 186 + 2.392 2.350 -0.140
ENSG00000070614 E027 214.6901572 0.0018338353 2.949460e-02 0.27752661 5 150539228 150539356 129 + 2.353 2.303 -0.166
ENSG00000070614 E028 202.4518771 0.0001700257 9.067358e-01 0.97795346 5 150540082 150540264 183 + 2.297 2.311 0.045
ENSG00000070614 E029 155.9908759 0.0002124559 7.789390e-01 0.94201429 5 150541570 150541666 97 + 2.179 2.203 0.083
ENSG00000070614 E030 159.1578581 0.0002033584 8.593714e-01 0.96555769 5 150542848 150542971 124 + 2.194 2.205 0.038
ENSG00000070614 E031 175.9954475 0.0003943824 7.866207e-01 0.94415564 5 150545312 150545486 175 + 2.229 2.253 0.080
ENSG00000070614 E032 217.9169340 0.0001974324 6.964507e-01 0.91377748 5 150548218 150548388 171 + 2.321 2.347 0.086
ENSG00000070614 E033 215.0292653 0.0031512297 6.493899e-01 0.89612812 5 150549678 150549787 110 + 2.314 2.345 0.103
ENSG00000070614 E034 2.3465970 0.0081976762 8.293039e-01 0.95669233 5 150550414 150550899 486 + 0.534 0.510 -0.113
ENSG00000070614 E035 224.7556813 0.0086811104 9.031908e-01 0.97704065 5 150551753 150551855 103 + 2.343 2.356 0.045
ENSG00000070614 E036 11.5652056 0.0023325350 7.844753e-01 0.94354205 5 150551856 150551894 39 + 1.071 1.112 0.149
ENSG00000070614 E037 2.7249291 0.0231833036 7.579538e-01 0.93518043 5 150552561 150552630 70 + 0.595 0.559 -0.166
ENSG00000070614 E038 4060.2972594 0.0008828979 6.595997e-05 0.01070535 5 150553213 150558211 4999 + 3.582 3.633 0.168