ENSG00000070501

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265421 ENSG00000070501 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLB protein_coding protein_coding 25.95157 10.36702 10.44865 2.802883 2.167071 0.01130545 6.0688224 2.1286371 2.3696185 1.0367280 0.40544895 0.1540386 0.22917500 0.18320000 0.25746667 0.07426667 0.756321289 0.001399488 FALSE TRUE
ENST00000518925 ENSG00000070501 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLB protein_coding protein_coding 25.95157 10.36702 10.44865 2.802883 2.167071 0.01130545 2.1346070 0.5238930 0.7846854 0.4461286 0.47991472 0.5738331 0.07215833 0.03736667 0.06086667 0.02350000 0.877163524 0.001399488 FALSE TRUE
ENST00000521290 ENSG00000070501 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLB protein_coding protein_coding 25.95157 10.36702 10.44865 2.802883 2.167071 0.01130545 2.1444960 0.5185043 0.9334750 0.2873993 0.65593619 0.8360691 0.07784583 0.04816667 0.07450000 0.02633333 0.829158659 0.001399488 FALSE TRUE
ENST00000521492 ENSG00000070501 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLB protein_coding protein_coding 25.95157 10.36702 10.44865 2.802883 2.167071 0.01130545 0.9294494 2.1621348 0.5035095 0.3393574 0.03260598 -2.0806509 0.05442500 0.22086667 0.05440000 -0.16646667 0.001399488 0.001399488   FALSE
MSTRG.31449.2 ENSG00000070501 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLB protein_coding   25.95157 10.36702 10.44865 2.802883 2.167071 0.01130545 12.2301796 2.8029402 4.6436098 0.8963617 1.45606569 0.7262714 0.45360417 0.26680000 0.41916667 0.15236667 0.313219017 0.001399488 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000070501 E001 0.2892872 0.0257489433 2.597874e-01   8 42338454 42338458 5 + 0.198 0.000 -11.765
ENSG00000070501 E002 0.4704972 0.0217681645 1.182961e-01   8 42338459 42338481 23 + 0.272 0.000 -12.352
ENSG00000070501 E003 1.1222045 0.0158871002 7.207378e-03   8 42338482 42338493 12 + 0.482 0.000 -13.577
ENSG00000070501 E004 6.5308379 0.0074354184 9.130386e-01 0.9792151466 8 42338494 42338506 13 + 0.884 0.880 -0.017
ENSG00000070501 E005 30.6098518 0.0010852639 7.498233e-01 0.9324903020 8 42338507 42338604 98 + 1.516 1.503 -0.044
ENSG00000070501 E006 26.1444204 0.0019243266 7.702057e-01 0.9395198807 8 42338605 42338628 24 + 1.427 1.453 0.089
ENSG00000070501 E007 39.8410940 0.0008515266 3.666220e-01 0.7513240019 8 42338629 42338685 57 + 1.639 1.596 -0.144
ENSG00000070501 E008 18.4866324 0.0017800698 6.280861e-01 0.8870514214 8 42339012 42339069 58 + 1.271 1.317 0.162
ENSG00000070501 E009 0.9786866 0.0483778097 6.230799e-03   8 42339070 42339380 311 + 0.000 0.488 13.703
ENSG00000070501 E010 0.9886040 0.2336035552 3.660744e-01   8 42339693 42340147 455 + 0.198 0.380 1.278
ENSG00000070501 E011 28.5032905 0.0010230282 6.203920e-01 0.8842260054 8 42344953 42344959 7 + 1.489 1.464 -0.085
ENSG00000070501 E012 38.9302153 0.0008294564 4.693248e-01 0.8136218784 8 42344960 42345019 60 + 1.624 1.593 -0.107
ENSG00000070501 E013 28.4104817 0.0009550091 7.551066e-01 0.9343273788 8 42349016 42349038 23 + 1.467 1.494 0.090
ENSG00000070501 E014 36.2400497 0.0010030082 8.533628e-01 0.9636365820 8 42349039 42349090 52 + 1.589 1.585 -0.015
ENSG00000070501 E015 2.5041844 0.1990082876 4.118569e-01 0.7816672369 8 42349091 42349289 199 + 0.441 0.620 0.847
ENSG00000070501 E016 39.2120542 0.0036091782 9.142120e-01 0.9794616924 8 42350007 42350065 59 + 1.609 1.628 0.064
ENSG00000070501 E017 37.8133497 0.0027298415 2.453774e-01 0.6509499818 8 42352519 42352568 50 + 1.628 1.572 -0.192
ENSG00000070501 E018 6.2908346 0.0187641891 8.563737e-01 0.9645590977 8 42354417 42354521 105 + 0.895 0.879 -0.062
ENSG00000070501 E019 1.4302391 0.0119314474 5.508823e-02   8 42355459 42355515 57 + 0.198 0.535 2.068
ENSG00000070501 E020 43.9071847 0.0008428687 8.937557e-01 0.9746377147 8 42355516 42355567 52 + 1.658 1.673 0.051
ENSG00000070501 E021 32.5101741 0.0009167145 3.589163e-01 0.7460513755 8 42357169 42357173 5 + 1.560 1.513 -0.161
ENSG00000070501 E022 38.9407395 0.0007877348 4.083081e-01 0.7792042723 8 42357174 42357197 24 + 1.630 1.593 -0.127
ENSG00000070501 E023 37.2807675 0.0008588978 7.028151e-01 0.9161012252 8 42357198 42357223 26 + 1.599 1.585 -0.049
ENSG00000070501 E024 50.3645279 0.0029238129 2.288601e-01 0.6340510978 8 42357320 42357392 73 + 1.748 1.694 -0.182
ENSG00000070501 E025 1.6595607 0.0112077230 3.759609e-03 0.1097565790 8 42357393 42357942 550 + 0.110 0.615 3.429
ENSG00000070501 E026 2.5261698 0.0087063154 8.772378e-01 0.9705423315 8 42361096 42361202 107 + 0.557 0.535 -0.101
ENSG00000070501 E027 31.3008551 0.0036870077 3.022462e-01 0.7015879881 8 42361295 42361297 3 + 1.548 1.493 -0.188
ENSG00000070501 E028 51.5655659 0.0060792200 3.054042e-01 0.7042515710 8 42361298 42361365 68 + 1.755 1.707 -0.162
ENSG00000070501 E029 0.6920142 0.0199899049 8.766051e-01   8 42361366 42361712 347 + 0.199 0.229 0.257
ENSG00000070501 E030 52.4206408 0.0007657467 8.180052e-01 0.9539607018 8 42362612 42362698 87 + 1.739 1.735 -0.011
ENSG00000070501 E031 16.6823246 0.0405314248 4.332240e-07 0.0003107754 8 42368936 42369270 335 + 0.813 1.472 2.380
ENSG00000070501 E032 54.4189691 0.0118075966 8.649359e-01 0.9670751223 8 42369271 42369335 65 + 1.741 1.757 0.057
ENSG00000070501 E033 4.6778846 0.1009267199 8.460269e-02 0.4269970661 8 42369607 42369848 242 + 0.564 0.881 1.308
ENSG00000070501 E034 76.8638892 0.0180815019 5.672343e-01 0.8609923647 8 42369849 42369988 140 + 1.882 1.906 0.081
ENSG00000070501 E035 0.1717682 0.0555406468 4.177509e-01   8 42370114 42370181 68 + 0.000 0.129 11.122
ENSG00000070501 E036 62.5630674 0.0211370003 3.319908e-01 0.7260543575 8 42371563 42371813 251 + 1.773 1.835 0.209