ENSG00000070081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323688 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding protein_coding 35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 13.028849 2.9598394 5.4631499 1.2428420 1.2558144 0.8819865 0.32646667 0.26133333 0.37853333 0.11720000 0.5988043447 0.0004928005 FALSE TRUE
MSTRG.5229.11 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding   35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 2.404556 2.1543434 0.8915628 0.4196804 0.1457412 -1.2634295 0.09340000 0.20896667 0.06336667 -0.14560000 0.0004928005 0.0004928005 FALSE TRUE
MSTRG.5229.14 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding   35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 2.470005 0.0000000 0.7765199 0.0000000 0.3456956 6.2974114 0.05452500 0.00000000 0.04716667 0.04716667 0.0053371243 0.0004928005 FALSE TRUE
MSTRG.5229.15 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding   35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 1.606476 1.0425581 1.2592148 0.3986776 0.6531970 0.2700364 0.05778333 0.09406667 0.07430000 -0.01976667 0.7793796390 0.0004928005 FALSE TRUE
MSTRG.5229.23 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding   35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 4.017382 0.5355031 3.3162349 0.2707659 1.0241120 2.6082307 0.12322083 0.05150000 0.23583333 0.18433333 0.2656607830 0.0004928005 FALSE TRUE
MSTRG.5229.31 ENSG00000070081 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUCB2 protein_coding   35.33699 10.6459 14.64343 2.733043 2.857462 0.4595863 2.197124 1.6443357 1.1307762 0.1707339 0.6150599 -0.5362361 0.12309167 0.16556667 0.08326667 -0.08230000 0.7073916342 0.0004928005 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000070081 E001 0.1125166 0.0319086770 6.246027e-01   11 17208153 17208426 274 + 0.105 0.000 -11.429
ENSG00000070081 E002 0.0000000       11 17260340 17260355 16 +      
ENSG00000070081 E003 0.0000000       11 17260356 17260501 146 +      
ENSG00000070081 E004 0.0000000       11 17260537 17261465 929 +      
ENSG00000070081 E005 0.0000000       11 17267588 17267681 94 +      
ENSG00000070081 E006 0.0000000       11 17268068 17268257 190 +      
ENSG00000070081 E007 0.1812101 0.0415625390 6.218440e-01   11 17269185 17269197 13 + 0.106 0.000 -12.913
ENSG00000070081 E008 0.3579807 0.0374686217 2.882139e-01   11 17269198 17269331 134 + 0.191 0.000 -13.904
ENSG00000070081 E009 0.0000000       11 17275613 17275616 4 +      
ENSG00000070081 E010 0.0000000       11 17275617 17275909 293 +      
ENSG00000070081 E011 0.0000000       11 17275910 17276007 98 +      
ENSG00000070081 E012 0.0000000       11 17276008 17276010 3 +      
ENSG00000070081 E013 0.1717682 0.0370176701 3.798643e-01   11 17276011 17276203 193 + 0.000 0.135 13.279
ENSG00000070081 E014 0.3435364 0.4668550180 2.381179e-01   11 17276718 17276720 3 + 0.000 0.239 13.683
ENSG00000070081 E015 0.3435364 0.4668550180 2.381179e-01   11 17276721 17276724 4 + 0.000 0.239 13.683
ENSG00000070081 E016 0.3435364 0.4668550180 2.381179e-01   11 17276725 17276725 1 + 0.000 0.239 13.683
ENSG00000070081 E017 0.3435364 0.4668550180 2.381179e-01   11 17276726 17276730 5 + 0.000 0.239 13.683
ENSG00000070081 E018 0.6697652 0.1948366420 3.870808e-02   11 17276731 17276733 3 + 0.000 0.391 14.915
ENSG00000070081 E019 1.3754879 0.0983189463 6.087844e-02   11 17276734 17276738 5 + 0.188 0.550 2.238
ENSG00000070081 E020 1.4880045 0.1804202980 1.594689e-01   11 17276739 17276740 2 + 0.253 0.549 1.685
ENSG00000070081 E021 2.3473474 0.0164747135 7.728774e-02 0.411947829 11 17276741 17276749 9 + 0.375 0.668 1.415
ENSG00000070081 E022 34.3794251 0.0218159295 1.974716e-01 0.600639161 11 17276750 17276828 79 + 1.509 1.612 0.354
ENSG00000070081 E023 2.0435185 0.0093308423 2.743995e-01 0.678218224 11 17276829 17276830 2 + 0.573 0.391 -0.907
ENSG00000070081 E024 2.2685517 0.0093947355 1.451458e-01 0.532488227 11 17276831 17276848 18 + 0.632 0.391 -1.167
ENSG00000070081 E025 0.2920894 0.0283387448 8.340684e-01   11 17276984 17276985 2 + 0.105 0.135 0.417
ENSG00000070081 E026 0.8852955 0.0160952892 2.494507e-01   11 17276986 17277003 18 + 0.190 0.391 1.416
ENSG00000070081 E027 1.0620661 0.0141095497 4.618715e-01   11 17277004 17277013 10 + 0.261 0.391 0.829
ENSG00000070081 E028 2.3276522 0.0085647354 7.849033e-01 0.943702007 11 17277014 17277022 9 + 0.505 0.551 0.221
ENSG00000070081 E029 4.8134079 0.0049252145 2.628034e-01 0.667901293 11 17277023 17277095 73 + 0.708 0.858 0.596
ENSG00000070081 E030 1.5651557 0.0136211630 2.878497e-01   11 17277096 17277194 99 + 0.504 0.321 -1.000
ENSG00000070081 E031 1.3695013 0.2525550052 5.867702e-01   11 17277195 17277297 103 + 0.356 0.448 0.508
ENSG00000070081 E032 0.0000000       11 17278362 17278537 176 +      
ENSG00000070081 E033 77.0702692 0.0061144242 1.153908e-01 0.485275106 11 17282789 17282943 155 + 1.861 1.942 0.271
ENSG00000070081 E034 0.6261229 0.0434312704 2.041920e-01   11 17283461 17283564 104 + 0.105 0.322 2.004
ENSG00000070081 E035 8.2270218 0.0046512062 2.061093e-01 0.609993864 11 17286634 17286713 80 + 0.910 1.050 0.523
ENSG00000070081 E036 3.2140221 0.0065505494 3.995883e-01 0.773187420 11 17286714 17286717 4 + 0.573 0.701 0.552
ENSG00000070081 E037 3.4865674 0.0090463531 1.843825e-01 0.584773825 11 17291240 17291365 126 + 0.752 0.551 -0.861
ENSG00000070081 E038 113.8073075 0.0003107633 6.282743e-01 0.887150888 11 17295324 17295467 144 + 2.072 2.061 -0.039
ENSG00000070081 E039 0.1717682 0.0370176701 3.798643e-01   11 17295468 17295604 137 + 0.000 0.135 13.279
ENSG00000070081 E040 115.7013564 0.0007770262 6.122079e-01 0.881015835 11 17296104 17296211 108 + 2.076 2.066 -0.035
ENSG00000070081 E041 132.6112860 0.0002886243 2.311336e-01 0.636153771 11 17301744 17301870 127 + 2.147 2.115 -0.105
ENSG00000070081 E042 113.7014516 0.0002884322 8.450219e-04 0.049132541 11 17309572 17309675 104 + 2.109 2.005 -0.350
ENSG00000070081 E043 115.0415520 0.0003177585 3.328664e-01 0.726825074 11 17310825 17310919 95 + 2.083 2.055 -0.091
ENSG00000070081 E044 105.7619962 0.0003242052 4.077075e-01 0.778744944 11 17310920 17311010 91 + 2.023 2.054 0.103
ENSG00000070081 E045 0.0000000       11 17311185 17311192 8 +      
ENSG00000070081 E046 129.4221654 0.0002451107 9.242108e-01 0.981972793 11 17311193 17311283 91 + 2.119 2.126 0.022
ENSG00000070081 E047 0.4465501 0.0217681645 4.195193e-01   11 17311839 17311871 33 + 0.105 0.238 1.415
ENSG00000070081 E048 121.4113961 0.0002452421 7.458204e-01 0.931418052 11 17311872 17311930 59 + 2.098 2.091 -0.022
ENSG00000070081 E049 123.4045796 0.0002962099 8.671293e-01 0.967373309 11 17312028 17312080 53 + 2.103 2.102 -0.006
ENSG00000070081 E050 104.1843304 0.0003526672 4.376781e-01 0.796258474 11 17312081 17312120 40 + 2.040 2.017 -0.076
ENSG00000070081 E051 116.1429662 0.0004053095 8.665884e-01 0.967314151 11 17315386 17315475 90 + 2.074 2.073 -0.002
ENSG00000070081 E052 0.1125166 0.0319086770 6.246027e-01   11 17317584 17317706 123 + 0.105 0.000 -12.906
ENSG00000070081 E053 149.2914869 0.0002439593 5.471779e-01 0.852789043 11 17330127 17330297 171 + 2.174 2.194 0.068
ENSG00000070081 E054 95.3009798 0.0003204772 6.520258e-01 0.897376726 11 17330902 17330983 82 + 1.994 1.982 -0.040
ENSG00000070081 E055 0.7232030 0.6761023782 7.533831e-01   11 17330984 17331390 407 + 0.279 0.137 -1.284
ENSG00000070081 E056 52.2696237 0.0057208737 4.017367e-01 0.774572243 11 17331412 17332041 630 + 1.746 1.701 -0.151
ENSG00000070081 E057 20.4466169 0.0351289400 1.785482e-02 0.225133536 11 17332042 17334480 2439 + 1.175 1.457 0.985
ENSG00000070081 E058 1.7585198 0.0103490248 4.569932e-01 0.807083977 11 17337024 17337083 60 + 0.375 0.504 0.675
ENSG00000070081 E059 3.7725522 0.1413559384 6.841981e-01 0.909723301 11 17337348 17337534 187 + 0.625 0.754 0.535
ENSG00000070081 E060 17.5355218 0.0015033333 2.480967e-05 0.005578272 11 17349345 17349980 636 + 1.079 1.425 1.219