ENSG00000070061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537196 ENSG00000070061 HEK293_DMSO_6hA HEK293_OSMI2_6hA ELP1 protein_coding protein_coding 34.32196 21.04154 19.91044 5.586115 3.21685 -0.07967628 12.3951540 11.22720521 10.273872 3.01548414 1.9499186 -0.12789977 0.39531250 0.533866667 0.51010000 -0.02376667 7.645268e-01 8.487982e-08 FALSE TRUE
ENST00000674535 ENSG00000070061 HEK293_DMSO_6hA HEK293_OSMI2_6hA ELP1 protein_coding protein_coding 34.32196 21.04154 19.91044 5.586115 3.21685 -0.07967628 6.7644387 1.98655078 2.844746 0.51187928 0.5158911 0.51585269 0.17750833 0.095600000 0.14246667 0.04686667 3.057535e-01 8.487982e-08 FALSE TRUE
ENST00000675052 ENSG00000070061 HEK293_DMSO_6hA HEK293_OSMI2_6hA ELP1 protein_coding protein_coding 34.32196 21.04154 19.91044 5.586115 3.21685 -0.07967628 2.1791514 1.42915052 1.521152 0.53147530 0.3994710 0.08940016 0.06365417 0.064666667 0.07336667 0.00870000 8.607136e-01 8.487982e-08 FALSE TRUE
ENST00000676162 ENSG00000070061 HEK293_DMSO_6hA HEK293_OSMI2_6hA ELP1 protein_coding processed_transcript 34.32196 21.04154 19.91044 5.586115 3.21685 -0.07967628 1.4044571 1.26266304 0.000000 0.38166625 0.0000000 -6.99170668 0.05659167 0.064666667 0.00000000 -0.06466667 8.487982e-08 8.487982e-08 FALSE TRUE
MSTRG.33210.3 ENSG00000070061 HEK293_DMSO_6hA HEK293_OSMI2_6hA ELP1 protein_coding   34.32196 21.04154 19.91044 5.586115 3.21685 -0.07967628 0.9366884 0.07942539 1.531532 0.07942539 0.7759223 4.10753648 0.03228333 0.004433333 0.06633333 0.06190000 4.616552e-01 8.487982e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000070061 E001 0.3375497 0.4019377199 0.2049011013   9 108866898 108867515 618 - 0.279 0.000 -13.798
ENSG00000070061 E002 0.1125166 0.0327899314 0.4659139615   9 108867516 108867516 1 - 0.122 0.000 -12.455
ENSG00000070061 E003 0.2920894 0.0279247124 0.9670047206   9 108867517 108867537 21 - 0.122 0.117 -0.058
ENSG00000070061 E004 0.4732995 0.0214012280 0.5362177878   9 108867538 108867539 2 - 0.217 0.117 -1.061
ENSG00000070061 E005 10.6914834 0.0031820765 0.1527884685 0.54316230 9 108867540 108868172 633 - 1.135 1.000 -0.490
ENSG00000070061 E006 45.8970406 0.0005946613 0.4162734517 0.78425869 9 108868173 108868445 273 - 1.644 1.696 0.177
ENSG00000070061 E007 46.8751121 0.0015212339 0.8661054161 0.96724737 9 108868446 108868549 104 - 1.677 1.693 0.056
ENSG00000070061 E008 53.0538056 0.0014010387 0.9063329883 0.97782798 9 108868550 108868640 91 - 1.735 1.740 0.014
ENSG00000070061 E009 37.9097753 0.0027218467 0.3206963935 0.71717943 9 108868641 108868650 10 - 1.549 1.619 0.239
ENSG00000070061 E010 75.1897954 0.0049194524 0.0936089719 0.44520985 9 108868651 108868670 20 - 1.823 1.923 0.339
ENSG00000070061 E011 91.6851398 0.0079900593 0.2390406101 0.64428328 9 108868671 108868720 50 - 1.925 1.998 0.245
ENSG00000070061 E012 404.6620745 0.0066775352 0.1417767082 0.52769876 9 108868721 108869030 310 - 2.575 2.634 0.195
ENSG00000070061 E013 247.9159070 0.0033809375 0.6599367459 0.90060412 9 108869031 108869114 84 - 2.385 2.405 0.066
ENSG00000070061 E014 233.3437603 0.0046995660 0.4534114565 0.80521229 9 108869115 108869182 68 - 2.353 2.385 0.108
ENSG00000070061 E015 8.8610493 0.0463232167 0.6188303816 0.88343001 9 108870454 108870553 100 - 0.949 1.014 0.244
ENSG00000070061 E016 2.8524887 0.0071876834 0.0850596662 0.42813459 9 108872661 108872801 141 - 0.716 0.456 -1.176
ENSG00000070061 E017 214.2645578 0.0008912215 0.1452435064 0.53266989 9 108874895 108874963 69 - 2.308 2.357 0.165
ENSG00000070061 E018 123.6951070 0.0004441192 0.0754592008 0.40798293 9 108874964 108874970 7 - 2.058 2.127 0.230
ENSG00000070061 E019 3.0335842 0.0072439571 0.0058637118 0.13627529 9 108874971 108875632 662 - 0.295 0.752 2.257
ENSG00000070061 E020 1.0210453 0.0150359441 0.1094355364   9 108875633 108875735 103 - 0.122 0.407 2.258
ENSG00000070061 E021 1.1582594 0.0152506537 0.0049730154   9 108875736 108876701 966 - 0.000 0.501 14.974
ENSG00000070061 E022 0.3435364 0.7044778189 0.3845477902   9 108876898 108876986 89 - 0.000 0.211 13.176
ENSG00000070061 E023 0.8766504 0.4472859221 0.7202365866   9 108876987 108877612 626 - 0.225 0.288 0.473
ENSG00000070061 E024 0.3356707 0.0267188923 0.9595772604   9 108877613 108877800 188 - 0.122 0.117 -0.066
ENSG00000070061 E025 1.8836626 0.0468864052 0.8858288681 0.97275137 9 108877801 108877994 194 - 0.422 0.456 0.175
ENSG00000070061 E026 257.5598635 0.0013274381 0.3653204801 0.75045423 9 108877995 108878149 155 - 2.396 2.429 0.113
ENSG00000070061 E027 223.9292166 0.0002300024 0.4486371144 0.80284241 9 108878623 108878750 128 - 2.360 2.352 -0.027
ENSG00000070061 E028 0.1717682 0.0534494331 0.5151422489   9 108878751 108878988 238 - 0.000 0.117 12.168
ENSG00000070061 E029 117.0292703 0.0003276761 0.3997418006 0.77319184 9 108879446 108879460 15 - 2.087 2.070 -0.058
ENSG00000070061 E030 183.0425958 0.0024064677 0.5896719396 0.87119844 9 108879461 108879557 97 - 2.276 2.263 -0.043
ENSG00000070061 E031 178.9626740 0.0007486268 0.7216008363 0.92268801 9 108880052 108880165 114 - 2.259 2.257 -0.007
ENSG00000070061 E032 4.4230050 0.1611829230 0.2001760563 0.60366530 9 108880166 108880943 778 - 0.563 0.835 1.137
ENSG00000070061 E033 2.4970692 0.0101818065 0.0256890646 0.26091996 9 108880944 108881662 719 - 0.295 0.674 1.938
ENSG00000070061 E034 3.9787512 0.0703513535 0.4964227925 0.82748915 9 108881663 108881704 42 - 0.761 0.646 -0.474
ENSG00000070061 E035 118.1429517 0.0005470487 0.8744923748 0.96968875 9 108881705 108881765 61 - 2.077 2.080 0.011
ENSG00000070061 E036 117.1197080 0.0044230704 0.8686853171 0.96772507 9 108882125 108882187 63 - 2.067 2.076 0.028
ENSG00000070061 E037 4.2770942 0.0847535059 0.1050621412 0.46686966 9 108882188 108882562 375 - 0.525 0.818 1.247
ENSG00000070061 E038 0.5297488 0.0292467040 0.5343780104   9 108884796 108884912 117 - 0.218 0.117 -1.068
ENSG00000070061 E039 1.1319246 0.0142105410 0.0599771784   9 108885768 108885872 105 - 0.122 0.457 2.525
ENSG00000070061 E040 120.4619116 0.0003316306 0.5768743289 0.86533852 9 108889332 108889393 62 - 2.090 2.082 -0.028
ENSG00000070061 E041 0.3262289 0.0274424043 0.2213783826   9 108889645 108889684 40 - 0.000 0.210 13.166
ENSG00000070061 E042 233.3935106 0.0001698347 0.3342422033 0.72777007 9 108891203 108891404 202 - 2.378 2.366 -0.041
ENSG00000070061 E043 173.4306768 0.0002303439 0.4764883508 0.81744252 9 108892986 108893083 98 - 2.248 2.239 -0.031
ENSG00000070061 E044 1.8111317 0.0099902869 0.0392544304 0.31179473 9 108893084 108893942 859 - 0.217 0.579 2.108
ENSG00000070061 E045 169.6708343 0.0002363695 0.4345879313 0.79415924 9 108893943 108894066 124 - 2.238 2.227 -0.036
ENSG00000070061 E046 0.1812101 0.0370215145 0.4637927534   9 108894067 108894088 22 - 0.122 0.000 -12.463
ENSG00000070061 E047 177.3411824 0.0001995276 0.1619320547 0.55669057 9 108896496 108896644 149 - 2.268 2.241 -0.088
ENSG00000070061 E048 1.9879023 0.0099472603 0.1025218817 0.46193737 9 108896645 108896890 246 - 0.295 0.579 1.522
ENSG00000070061 E049 3.7119223 0.0197459888 0.6125357920 0.88116355 9 108896891 108896952 62 - 0.715 0.645 -0.297
ENSG00000070061 E050 124.5255435 0.0004034576 0.0284803527 0.27350268 9 108896953 108897038 86 - 2.133 2.074 -0.200
ENSG00000070061 E051 142.0216431 0.0003290131 0.3954613774 0.77027022 9 108897148 108897283 136 - 2.165 2.151 -0.050
ENSG00000070061 E052 54.2074153 0.0005731001 0.8472799674 0.96219838 9 108897284 108897285 2 - 1.731 1.750 0.064
ENSG00000070061 E053 3.2179833 0.1283111228 0.1870850784 0.58811096 9 108897286 108898135 850 - 0.424 0.745 1.466
ENSG00000070061 E054 0.3089214 0.0639804839 0.2369081206   9 108898136 108898234 99 - 0.000 0.209 13.162
ENSG00000070061 E055 0.4465501 0.0217681645 0.6097093370   9 108898235 108898501 267 - 0.122 0.210 0.941
ENSG00000070061 E056 89.2710315 0.0015555831 0.6054584190 0.87782728 9 108898502 108898581 80 - 1.938 1.967 0.100
ENSG00000070061 E057 111.4245266 0.0003125608 0.4581471531 0.80758134 9 108898671 108898749 79 - 2.030 2.066 0.118
ENSG00000070061 E058 120.3827777 0.0003074818 0.5236393471 0.84189929 9 108899822 108899895 74 - 2.066 2.097 0.105
ENSG00000070061 E059 147.0379363 0.0002817899 0.9661806973 0.99224595 9 108900260 108900375 116 - 2.165 2.175 0.033
ENSG00000070061 E060 124.3730573 0.0002452704 0.7806367432 0.94242058 9 108901425 108901530 106 - 2.090 2.110 0.065
ENSG00000070061 E061 87.3686587 0.0003715419 0.1372863045 0.52116965 9 108901628 108901681 54 - 1.910 1.977 0.226
ENSG00000070061 E062 114.8789106 0.0011977631 0.2879349763 0.68989086 9 108902839 108902942 104 - 2.042 2.091 0.163
ENSG00000070061 E063 116.4243357 0.0002566975 0.3142220828 0.71159534 9 108903563 108903658 96 - 2.085 2.063 -0.074
ENSG00000070061 E064 59.5694523 0.0010619474 0.3409997465 0.73270242 9 108903659 108903669 11 - 1.803 1.770 -0.109
ENSG00000070061 E065 142.9967246 0.0068369499 0.2021518988 0.60586201 9 108906303 108906485 183 - 2.181 2.141 -0.133
ENSG00000070061 E066 9.3789135 0.2933038849 0.1923194685 0.59439677 9 108906486 108908304 1819 - 0.852 1.111 0.964
ENSG00000070061 E067 104.6320645 0.0071447218 0.8181383894 0.95398016 9 108908305 108908404 100 - 2.021 2.029 0.024
ENSG00000070061 E068 144.7578857 0.0080335972 0.5150128535 0.83763540 9 108911010 108911180 171 - 2.141 2.185 0.147
ENSG00000070061 E069 0.5231092 0.2123370699 0.1170525065   9 108911181 108911211 31 - 0.000 0.287 13.761
ENSG00000070061 E070 152.6270350 0.0079613067 0.8781274635 0.97079076 9 108912264 108912494 231 - 2.180 2.194 0.048
ENSG00000070061 E071 84.5641723 0.0042537057 0.5979939658 0.87482328 9 108916204 108916297 94 - 1.941 1.929 -0.042
ENSG00000070061 E072 0.9071299 0.2059412628 0.6799402214   9 108916298 108917546 1249 - 0.216 0.346 0.918
ENSG00000070061 E073 92.9403420 0.0046552346 0.6286690157 0.88734667 9 108917547 108917662 116 - 1.979 1.972 -0.023
ENSG00000070061 E074 57.2056233 0.0077900564 0.6419695067 0.89327504 9 108917663 108917670 8 - 1.772 1.759 -0.043
ENSG00000070061 E075 68.1343319 0.1724867618 0.1898422956 0.59122603 9 108917671 108918810 1140 - 1.706 1.925 0.739
ENSG00000070061 E076 86.1438173 0.0003599614 0.5513036040 0.85451281 9 108918811 108918901 91 - 1.951 1.939 -0.041
ENSG00000070061 E077 17.6142433 0.2027625302 0.1085548607 0.47292109 9 108918902 108919252 351 - 1.061 1.387 1.153
ENSG00000070061 E078 83.9924692 0.0004093642 0.0837440678 0.42529256 9 108919253 108919349 97 - 1.961 1.905 -0.187
ENSG00000070061 E079 1.0542615 0.0181907626 0.7720147081   9 108920316 108920690 375 - 0.294 0.350 0.355
ENSG00000070061 E080 0.5932061 0.0196368620 0.3480159048   9 108920691 108920783 93 - 0.122 0.285 1.524
ENSG00000070061 E081 2.8813846 0.0676795652 0.0721573027 0.40018747 9 108920784 108922841 2058 - 0.365 0.701 1.611
ENSG00000070061 E082 91.4710326 0.0003474730 0.1332148384 0.51491446 9 108922842 108922927 86 - 1.990 1.947 -0.148
ENSG00000070061 E083 88.4350471 0.0011939770 0.0439116195 0.32627345 9 108926523 108926595 73 - 1.990 1.922 -0.228
ENSG00000070061 E084 55.4206195 0.0047462931 0.1280901790 0.50737393 9 108926596 108926603 8 - 1.796 1.723 -0.246
ENSG00000070061 E085 96.5542295 0.0003456861 0.0578935654 0.36581737 9 108927372 108927453 82 - 2.025 1.967 -0.192
ENSG00000070061 E086 100.5019919 0.0003542729 0.0046881176 0.12288695 9 108929769 108929921 153 - 2.058 1.969 -0.298
ENSG00000070061 E087 57.0935765 0.0005176252 0.2187143219 0.62331983 9 108930997 108931056 60 - 1.794 1.747 -0.156
ENSG00000070061 E088 35.6009007 0.0008636423 0.3700111996 0.75350340 9 108931057 108931080 24 - 1.586 1.545 -0.140
ENSG00000070061 E089 54.8461082 0.0005246341 0.0261463585 0.26295363 9 108931081 108931199 119 - 1.800 1.707 -0.316
ENSG00000070061 E090 20.0509250 0.0017913617 0.0403454002 0.31523634 9 108931200 108931201 2 - 1.402 1.257 -0.508
ENSG00000070061 E091 34.1281717 0.1905086104 0.0837468230 0.42529256 9 108931202 108933863 2662 - 1.351 1.659 1.058
ENSG00000070061 E092 68.8804388 0.0004049499 0.0004277182 0.03282851 9 108933864 108934063 200 - 1.917 1.780 -0.462
ENSG00000070061 E093 22.5864014 0.0024978184 0.0301958001 0.28035163 9 108934064 108934328 265 - 1.446 1.299 -0.510
ENSG00000070061 E094 0.3591457 0.4826194939 0.3361634408   9 108934367 108934449 83 - 0.000 0.212 13.190