ENSG00000068400

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376423 ENSG00000068400 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRIPAP1 protein_coding protein_coding 23.5643 29.71002 31.02907 1.718816 1.295738 0.06265027 7.204116 5.1862266 11.527013 0.3709048 1.5489683 1.1507335 0.29290417 0.17576667 0.37213333 0.1963667 0.00436078 0.00436078 FALSE TRUE
ENST00000619149 ENSG00000068400 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRIPAP1 protein_coding retained_intron 23.5643 29.71002 31.02907 1.718816 1.295738 0.06265027 4.070986 8.6756311 5.220787 0.7913527 1.4657426 -0.7316026 0.17312083 0.29096667 0.16690000 -0.1240667 0.20524145 0.00436078 TRUE TRUE
MSTRG.34228.5 ENSG00000068400 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRIPAP1 protein_coding   23.5643 29.71002 31.02907 1.718816 1.295738 0.06265027 2.701041 4.3441519 3.705401 0.7520681 2.1996569 -0.2288737 0.12112500 0.14803333 0.12453333 -0.0235000 0.82787137 0.00436078 FALSE TRUE
MSTRG.34228.6 ENSG00000068400 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRIPAP1 protein_coding   23.5643 29.71002 31.02907 1.718816 1.295738 0.06265027 2.445823 2.9836614 3.295896 0.1142570 0.2454922 0.1431301 0.09937917 0.10073333 0.10643333 0.0057000 0.91045525 0.00436078 FALSE TRUE
MSTRG.34228.7 ENSG00000068400 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRIPAP1 protein_coding   23.5643 29.71002 31.02907 1.718816 1.295738 0.06265027 1.427314 0.9194891 1.745003 0.2123752 0.8197880 0.9169635 0.06488333 0.03176667 0.05416667 0.0224000 0.87054555 0.00436078 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000068400 E001 4.0516544 0.0090574738 0.000334913 0.02835877 X 48973720 48973722 3 - 0.344 0.902 2.529
ENSG00000068400 E002 18.6901066 0.0332181010 0.350955497 0.74023430 X 48973723 48973781 59 - 1.238 1.353 0.402
ENSG00000068400 E003 41.9295468 0.0007000308 0.632152477 0.88886058 X 48973782 48973854 73 - 1.637 1.625 -0.038
ENSG00000068400 E004 91.6274701 0.0004117697 0.836585347 0.95910310 X 48973855 48973930 76 - 1.963 1.970 0.023
ENSG00000068400 E005 87.8880571 0.0003172068 0.714668436 0.92025697 X 48973931 48973986 56 - 1.931 1.959 0.095
ENSG00000068400 E006 138.3144023 0.0002311378 0.087502341 0.43318054 X 48973987 48974068 82 - 2.106 2.172 0.221
ENSG00000068400 E007 276.9256068 0.0001337307 0.814065026 0.95268547 X 48974069 48974285 217 - 2.431 2.451 0.065
ENSG00000068400 E008 243.7199464 0.0006531644 0.486239303 0.82262986 X 48975155 48975291 137 - 2.388 2.385 -0.009
ENSG00000068400 E009 122.4441066 0.0002913912 0.720988979 0.92261515 X 48975292 48975309 18 - 2.074 2.100 0.088
ENSG00000068400 E010 234.4095508 0.0675184790 0.008353664 0.15943158 X 48975310 48976017 708 - 2.203 2.490 0.957
ENSG00000068400 E011 218.9074982 0.0021646511 0.231935874 0.63700029 X 48976018 48976111 94 - 2.352 2.330 -0.076
ENSG00000068400 E012 43.8840014 0.0940790012 0.097794714 0.45324820 X 48976112 48976240 129 - 1.533 1.739 0.700
ENSG00000068400 E013 143.1648704 0.0044690051 0.390806843 0.76758592 X 48976241 48976255 15 - 2.166 2.146 -0.067
ENSG00000068400 E014 249.6514509 0.0039479372 0.827566024 0.95630359 X 48976256 48976363 108 - 2.392 2.401 0.030
ENSG00000068400 E015 40.2415729 0.0643406417 0.026223820 0.26327021 X 48976907 48977833 927 - 1.453 1.727 0.933
ENSG00000068400 E016 31.4927530 0.0674225587 0.030896285 0.28286664 X 48977834 48978304 471 - 1.339 1.630 1.000
ENSG00000068400 E017 278.5861257 0.0022410084 0.522381320 0.84127787 X 48978305 48978435 131 - 2.446 2.442 -0.011
ENSG00000068400 E018 0.4704972 0.0219425134 0.093056423   X 48980758 48980808 51 - 0.281 0.000 -10.272
ENSG00000068400 E019 231.3230961 0.0001905959 0.673628279 0.90539964 X 48981215 48981314 100 - 2.362 2.367 0.016
ENSG00000068400 E020 189.5875398 0.0002158738 0.088567242 0.43537197 X 48981416 48981472 57 - 2.293 2.264 -0.098
ENSG00000068400 E021 228.7531704 0.0035647944 0.286915104 0.68892542 X 48981596 48981691 96 - 2.376 2.349 -0.091
ENSG00000068400 E022 128.5392759 0.0036779156 0.656568910 0.89936551 X 48981795 48981872 78 - 2.117 2.110 -0.025
ENSG00000068400 E023 227.1837670 0.0010315253 0.753478560 0.93362559 X 48982979 48983092 114 - 2.346 2.368 0.074
ENSG00000068400 E024 264.4319419 0.0006584817 0.436134867 0.79518818 X 48983228 48983391 164 - 2.425 2.421 -0.014
ENSG00000068400 E025 184.3431851 0.0002263366 0.886373871 0.97278590 X 48983392 48983440 49 - 2.256 2.274 0.062
ENSG00000068400 E026 225.3044308 0.0001822944 0.639287874 0.89200119 X 48983775 48983870 96 - 2.351 2.354 0.012
ENSG00000068400 E027 244.5411136 0.0001539866 0.436832345 0.79570608 X 48985268 48985402 135 - 2.390 2.387 -0.010
ENSG00000068400 E028 173.3749944 0.0001787940 0.276246657 0.67996610 X 48987785 48987877 93 - 2.247 2.233 -0.048
ENSG00000068400 E029 141.9148972 0.0002223011 0.060778838 0.37360745 X 48988121 48988198 78 - 2.171 2.130 -0.137
ENSG00000068400 E030 27.5322560 0.1948236825 0.015098052 0.20907319 X 48988199 48988651 453 - 1.194 1.611 1.446
ENSG00000068400 E031 169.3141167 0.0001968812 0.028642152 0.27421183 X 48989611 48989710 100 - 2.250 2.206 -0.149
ENSG00000068400 E032 123.2622571 0.0002692668 0.198152238 0.60131327 X 48989835 48989882 48 - 2.104 2.078 -0.088
ENSG00000068400 E033 112.3401316 0.0002783001 0.692501286 0.91256875 X 48989972 48990003 32 - 2.050 2.052 0.005
ENSG00000068400 E034 124.6181739 0.0002536944 0.454468774 0.80586784 X 48990685 48990732 48 - 2.100 2.091 -0.030
ENSG00000068400 E035 135.1000698 0.0003672346 0.251364556 0.65727606 X 48990926 48991009 84 - 2.140 2.119 -0.069
ENSG00000068400 E036 137.5922830 0.0006022671 0.060104348 0.37188527 X 48991010 48991102 93 - 2.160 2.116 -0.148
ENSG00000068400 E037 73.3204571 0.0029697514 0.121560382 0.49641800 X 48991103 48991110 8 - 1.899 1.840 -0.199
ENSG00000068400 E038 1.8194696 0.1287581319 0.467951167 0.81286986 X 48991111 48991386 276 - 0.348 0.522 0.922
ENSG00000068400 E039 82.0880271 0.0004209117 0.261974538 0.66724364 X 48993428 48993447 20 - 1.933 1.904 -0.098
ENSG00000068400 E040 171.7228428 0.0002914172 0.282078273 0.68511776 X 48993448 48993578 131 - 2.244 2.229 -0.049
ENSG00000068400 E041 86.2091560 0.0009375138 0.462895583 0.81012594 X 48997250 48997258 9 - 1.916 1.960 0.148
ENSG00000068400 E042 167.8656923 0.0002158679 0.997898747 0.99939300 X 48997259 48997357 99 - 2.217 2.232 0.049
ENSG00000068400 E043 6.9461559 0.2404436460 0.335377553 0.72847135 X 48997948 48998153 206 - 0.829 0.953 0.472
ENSG00000068400 E044 91.3866201 0.0003116165 0.406864156 0.77812555 X 48998154 48998180 27 - 1.972 1.956 -0.054
ENSG00000068400 E045 2.5110989 0.0793572062 0.031524593 0.28538458 X 48998974 48999237 264 - 0.283 0.696 2.109
ENSG00000068400 E046 129.8026701 0.0002322870 0.913118277 0.97921515 X 48999238 48999299 62 - 2.108 2.119 0.038
ENSG00000068400 E047 1.1313225 0.1021555073 0.801011781   X 48999300 48999398 99 - 0.347 0.300 -0.297
ENSG00000068400 E048 110.5102538 0.0002633399 0.504458592 0.83189683 X 48999438 48999504 67 - 2.048 2.040 -0.026
ENSG00000068400 E049 2.4879120 0.0339933412 0.269860414 0.67426268 X 49000566 49000685 120 - 0.608 0.425 -0.880
ENSG00000068400 E050 0.3312313 0.0292870876 0.967213990   X 49000686 49000689 4 - 0.115 0.125 0.133
ENSG00000068400 E051 5.3466901 0.0104816682 0.422704394 0.78765049 X 49000861 49000959 99 - 0.848 0.752 -0.376
ENSG00000068400 E052 5.5159965 0.0468023388 0.177390964 0.57601205 X 49001184 49001313 130 - 0.692 0.917 0.889
ENSG00000068400 E053 66.0193681 0.0004550602 0.582307074 0.86775763 X 49002188 49002264 77 - 1.828 1.818 -0.031