ENSG00000068097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000184956 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding protein_coding 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 4.4874992 3.9222649 3.6978319 0.4821044 0.8374232 -0.0847847 0.26397917 0.19650000 0.20133333 0.004833333 0.99669960 0.04490996 FALSE  
ENST00000583979 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding miRNA 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 3.1387303 4.7040118 3.7655479 0.8259548 0.5448647 -0.3202693 0.17565833 0.23090000 0.20930000 -0.021600000 0.77410507 0.04490996    
ENST00000585976 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding protein_coding 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 1.1276588 1.8231900 1.3530770 0.3031554 0.7136733 -0.4274893 0.06445000 0.09016667 0.07903333 -0.011133333 0.79245509 0.04490996 FALSE  
ENST00000587003 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding nonsense_mediated_decay 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 1.8915311 2.2156969 3.2648058 0.5313367 0.2337210 0.5571522 0.10684167 0.10640000 0.18226667 0.075866667 0.04490996 0.04490996 FALSE  
ENST00000587314 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding nonsense_mediated_decay 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 0.9190348 2.0265158 0.2824227 0.4489615 0.2824227 -2.7999759 0.05106250 0.09880000 0.01410000 -0.084700000 0.14998051 0.04490996 FALSE  
ENST00000590587 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding nonsense_mediated_decay 17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 1.0549012 1.4652638 0.8197842 0.7751983 0.2018536 -0.8301649 0.06106667 0.06353333 0.04876667 -0.014766667 0.81481300 0.04490996 FALSE  
MSTRG.14800.6 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding   17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 2.2771169 1.4741010 2.6451127 0.1941617 1.4565075 0.8391838 0.13337083 0.07976667 0.13363333 0.053866667 0.99912476 0.04490996 FALSE  
MSTRG.14800.7 ENSG00000068097 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEATR6 protein_coding   17.3098 20.43615 18.00634 3.78984 1.714583 -0.1825237 0.8650183 0.8577246 0.3012009 0.4738791 0.1628232 -1.4793910 0.05184583 0.04190000 0.01870000 -0.023200000 0.89580161 0.04490996 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000068097 E001 94.7382831 0.0003901359 0.005547400 0.13262775 17 60041008 60043024 2017 - 1.916 2.020 0.347
ENSG00000068097 E002 166.1118686 0.0002786974 0.053656372 0.35468900 17 60043025 60043491 467 - 2.186 2.242 0.185
ENSG00000068097 E003 131.1771099 0.0015411694 0.632010138 0.88882890 17 60043492 60043562 71 - 2.103 2.122 0.064
ENSG00000068097 E004 142.8684546 0.0002554895 0.635415046 0.89041406 17 60043563 60043661 99 - 2.158 2.147 -0.039
ENSG00000068097 E005 74.7561302 0.0003998328 0.363426609 0.74923973 17 60043662 60043672 11 - 1.855 1.894 0.132
ENSG00000068097 E006 138.3323452 0.0002123308 0.073583079 0.40331355 17 60043673 60043799 127 - 2.110 2.165 0.185
ENSG00000068097 E007 232.4158139 0.0001702225 0.227050024 0.63197271 17 60043800 60044134 335 - 2.348 2.378 0.100
ENSG00000068097 E008 97.3148651 0.0002989113 0.977401876 0.99468192 17 60046025 60046099 75 - 1.988 1.991 0.011
ENSG00000068097 E009 107.3083108 0.0007126759 0.506699401 0.83313958 17 60046100 60046229 130 - 2.020 2.045 0.083
ENSG00000068097 E010 85.6200283 0.0038143970 0.335240628 0.72838183 17 60047309 60047363 55 - 1.911 1.957 0.153
ENSG00000068097 E011 89.3156893 0.0005046818 0.327202505 0.72254575 17 60047364 60047405 42 - 1.930 1.969 0.131
ENSG00000068097 E012 114.5265251 0.0002643815 0.536644138 0.84817647 17 60048264 60048369 106 - 2.047 2.069 0.075
ENSG00000068097 E013 56.4137441 0.0007710966 0.484563013 0.82187013 17 60048370 60048388 19 - 1.770 1.739 -0.103
ENSG00000068097 E014 127.8292257 0.0003477898 0.106433102 0.46904215 17 60049580 60049702 123 - 2.132 2.084 -0.161
ENSG00000068097 E015 67.7126371 0.0004450805 0.011768073 0.18750562 17 60050843 60050860 18 - 1.888 1.783 -0.353
ENSG00000068097 E016 118.9602623 0.0003005121 0.039754003 0.31335174 17 60050861 60050977 117 - 2.110 2.046 -0.214
ENSG00000068097 E017 98.1911433 0.0008878914 0.029912026 0.27911427 17 60055515 60055601 87 - 2.032 1.953 -0.266
ENSG00000068097 E018 102.2043325 0.0060312346 0.874600876 0.96971554 17 60056115 60056237 123 - 2.003 2.009 0.020
ENSG00000068097 E019 47.1642396 0.0044803370 0.304354392 0.70338024 17 60057048 60057056 9 - 1.639 1.702 0.213
ENSG00000068097 E020 179.8387603 0.0017581793 0.176721710 0.57505551 17 60057057 60057403 347 - 2.228 2.272 0.148
ENSG00000068097 E021 96.9605841 0.0003297284 0.215195227 0.61980370 17 60059422 60059521 100 - 1.961 2.007 0.156
ENSG00000068097 E022 134.7215823 0.0024986831 0.988951153 0.99724683 17 60059890 60060096 207 - 2.131 2.129 -0.005
ENSG00000068097 E023 100.6948272 0.0098094791 0.451732223 0.80443631 17 60066209 60066386 178 - 2.031 1.980 -0.169
ENSG00000068097 E024 0.1812101 0.0339051588 0.450783980   17 60066387 60066396 10 - 0.124 0.000 -9.591
ENSG00000068097 E025 2.4136532 0.0082173645 0.689498693 0.91157055 17 60067431 60067433 3 - 0.560 0.497 -0.296
ENSG00000068097 E026 131.6725178 0.0002998169 0.028820877 0.27493142 17 60067434 60067732 299 - 2.157 2.092 -0.216
ENSG00000068097 E027 75.1949729 0.0025962483 0.309647322 0.70785990 17 60069711 60069808 98 - 1.905 1.861 -0.150
ENSG00000068097 E028 49.3203038 0.0048100044 0.521308467 0.84070269 17 60069809 60069848 40 - 1.719 1.684 -0.117
ENSG00000068097 E029 72.4884980 0.0047281335 0.709907543 0.91866868 17 60070706 60070807 102 - 1.876 1.858 -0.058
ENSG00000068097 E030 31.5829763 0.0089473708 0.344171767 0.73504947 17 60072215 60072220 6 - 1.477 1.547 0.241
ENSG00000068097 E031 78.3168792 0.0034604453 0.793511608 0.94596127 17 60072221 60072329 109 - 1.892 1.906 0.045
ENSG00000068097 E032 68.9357917 0.0004485841 0.359687812 0.74658162 17 60073164 60073235 72 - 1.863 1.826 -0.122
ENSG00000068097 E033 53.3543034 0.0006408021 0.337701908 0.73021833 17 60073236 60073279 44 - 1.755 1.711 -0.147
ENSG00000068097 E034 67.7438974 0.0058534689 0.585060772 0.86907997 17 60073746 60073845 100 - 1.850 1.823 -0.089
ENSG00000068097 E035 47.2454572 0.0081649356 0.716544359 0.92085533 17 60073846 60073886 41 - 1.693 1.675 -0.061
ENSG00000068097 E036 11.1552256 0.0992153430 0.310905256 0.70877304 17 60073887 60073961 75 - 0.960 1.162 0.736
ENSG00000068097 E037 19.1524699 0.1060761239 0.160057812 0.55449712 17 60073962 60074086 125 - 1.145 1.398 0.890
ENSG00000068097 E038 16.5928700 0.1003026336 0.108815015 0.47343260 17 60074087 60074159 73 - 1.068 1.345 0.982
ENSG00000068097 E039 1.8573888 0.0107368275 0.865568447 0.96713877 17 60075615 60075704 90 - 0.422 0.453 0.158
ENSG00000068097 E040 2.8355667 0.0083500376 0.540101632 0.84991904 17 60075705 60075833 129 - 0.632 0.538 -0.422
ENSG00000068097 E041 63.1132607 0.0011234795 0.529667325 0.84475709 17 60076130 60076237 108 - 1.820 1.794 -0.088
ENSG00000068097 E042 0.3312313 0.0307290088 0.951167760   17 60076273 60076701 429 - 0.124 0.116 -0.107
ENSG00000068097 E043 60.1166455 0.0023712046 0.070372139 0.39646587 17 60078696 60078807 112 - 1.832 1.744 -0.298
ENSG00000068097 E044 43.2100911 0.0008210738 0.002674371 0.09275084 17 60078808 60078919 112 - 1.726 1.569 -0.532
ENSG00000068097 E045 7.4822909 0.0031886241 0.094812190 0.44769355 17 60078920 60078928 9 - 1.022 0.833 -0.713
ENSG00000068097 E046 5.7259204 0.0041341213 0.827060245 0.95611423 17 60079007 60079803 797 - 0.840 0.813 -0.102