ENSG00000067369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382039 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding protein_coding 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 2.6562094 0.9174656 1.7799565 0.5357073 0.2208266 0.9485588 0.20035833 0.0642000 0.18180000 0.11760000 0.52567844 0.02278996 FALSE TRUE
ENST00000382044 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding protein_coding 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 1.5191925 1.7472693 1.3877799 0.2669865 0.2308423 -0.3301981 0.12846667 0.1226000 0.13990000 0.01730000 0.80761901 0.02278996 FALSE TRUE
ENST00000411772 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding nonsense_mediated_decay 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 2.2008567 3.6401009 2.7662143 0.6399726 0.7266996 -0.3948174 0.20290000 0.2510000 0.27546667 0.02446667 0.94547266 0.02278996 FALSE TRUE
ENST00000417342 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding nonsense_mediated_decay 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 0.2989582 0.0000000 1.3432293 0.0000000 0.8224523 7.0802625 0.02544167 0.0000000 0.12150000 0.12150000 0.16035598 0.02278996 FALSE FALSE
ENST00000450115 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding protein_coding 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 2.8169893 2.2887368 0.8670630 0.6911597 0.4354107 -1.3900888 0.20917917 0.1552333 0.08286667 -0.07236667 0.73111212 0.02278996 FALSE TRUE
ENST00000467474 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding protein_coding 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 1.2534943 2.4106456 0.4450754 0.0916640 0.1012662 -2.4112145 0.09067083 0.1715333 0.04950000 -0.12203333 0.02278996 0.02278996 FALSE TRUE
ENST00000476454 ENSG00000067369 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP53BP1 protein_coding retained_intron 12.49761 14.25934 9.927073 1.425231 1.505498 -0.522026 0.5959767 1.5617774 0.5665737 0.1011501 0.2720497 -1.4468199 0.05391667 0.1110667 0.05866667 -0.05240000 0.59962093 0.02278996 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000067369 E001 182.0885229 0.0053603304 9.990755e-01 0.999732764 15 43403061 43407208 4148 - 2.251 2.249 -0.005
ENSG00000067369 E002 5.1419196 0.0058662042 7.411807e-01 0.929577851 15 43407209 43407213 5 - 0.801 0.760 -0.164
ENSG00000067369 E003 4.6567906 0.0233242653 4.475588e-01 0.802235302 15 43407214 43407215 2 - 0.802 0.695 -0.432
ENSG00000067369 E004 120.1928790 0.0002719251 1.628973e-01 0.557656349 15 43407216 43407570 355 - 2.037 2.086 0.161
ENSG00000067369 E005 127.3575441 0.0002589860 5.914847e-01 0.872029174 15 43407943 43408088 146 - 2.083 2.102 0.064
ENSG00000067369 E006 0.8392331 0.8178766774 6.719378e-01   15 43408661 43408896 236 - 0.351 0.180 -1.278
ENSG00000067369 E007 123.0516407 0.0006735502 3.930169e-01 0.768844086 15 43408897 43409009 113 - 2.057 2.088 0.102
ENSG00000067369 E008 104.9969597 0.0003149123 8.865473e-01 0.972794180 15 43409010 43409096 87 - 2.012 2.010 -0.009
ENSG00000067369 E009 0.5136063 0.0235478367 1.597184e-01   15 43409097 43409646 550 - 0.000 0.254 11.277
ENSG00000067369 E010 87.2521033 0.0017786297 8.670786e-02 0.431272460 15 43409647 43409741 95 - 1.974 1.905 -0.231
ENSG00000067369 E011 2.2944970 0.0085392017 6.959673e-01 0.913722092 15 43412672 43412767 96 - 0.463 0.529 0.324
ENSG00000067369 E012 105.6586865 0.0026755570 2.820087e-02 0.272327999 15 43413119 43413268 150 - 2.071 1.981 -0.302
ENSG00000067369 E013 77.2137883 0.0004506218 4.514178e-01 0.804316234 15 43413269 43413328 60 - 1.895 1.867 -0.094
ENSG00000067369 E014 48.1616944 0.0006431964 3.181616e-01 0.715207593 15 43413329 43413334 6 - 1.703 1.654 -0.165
ENSG00000067369 E015 0.3563434 0.0315031929 7.840135e-01   15 43414048 43414116 69 - 0.140 0.102 -0.527
ENSG00000067369 E016 2.5673344 0.4345772613 7.374027e-01 0.928138894 15 43415222 43415593 372 - 0.585 0.499 -0.401
ENSG00000067369 E017 99.4155254 0.0004129973 8.704117e-01 0.968228377 15 43415594 43415721 128 - 1.986 1.983 -0.012
ENSG00000067369 E018 68.7996231 0.0004540649 1.085074e-01 0.472894337 15 43415722 43415809 88 - 1.781 1.853 0.244
ENSG00000067369 E019 127.0210944 0.0015320451 6.301666e-02 0.379698093 15 43416225 43416416 192 - 2.048 2.118 0.234
ENSG00000067369 E020 18.4291724 0.2599683020 1.127511e-01 0.480502802 15 43416417 43417216 800 - 1.052 1.369 1.125
ENSG00000067369 E021 159.7211237 0.0009859380 3.108413e-01 0.708753456 15 43420305 43420617 313 - 2.172 2.205 0.111
ENSG00000067369 E022 84.1079798 0.0042288512 5.099585e-01 0.834729796 15 43420618 43420735 118 - 1.935 1.904 -0.102
ENSG00000067369 E023 55.4196086 0.0012275920 9.721290e-01 0.993417061 15 43421025 43421089 65 - 1.737 1.738 0.002
ENSG00000067369 E024 62.3601158 0.0005767699 7.792267e-01 0.942099617 15 43421090 43421174 85 - 1.794 1.783 -0.035
ENSG00000067369 E025 10.9177869 0.0065371785 5.732524e-05 0.009783015 15 43421672 43421854 183 - 0.714 1.192 1.799
ENSG00000067369 E026 130.5814541 0.0040771829 9.147805e-01 0.979624712 15 43421855 43422126 272 - 2.101 2.105 0.012
ENSG00000067369 E027 106.3323164 0.0056154642 4.122807e-01 0.781946568 15 43428016 43428168 153 - 2.038 2.000 -0.127
ENSG00000067369 E028 172.7195039 0.0004754878 5.903502e-01 0.871560056 15 43432194 43432648 455 - 2.236 2.222 -0.045
ENSG00000067369 E029 35.2467902 0.0014031215 4.931511e-01 0.825978187 15 43432649 43432677 29 - 1.518 1.561 0.148
ENSG00000067369 E030 55.2586844 0.0006020060 1.159068e-01 0.486075939 15 43438324 43438416 93 - 1.775 1.703 -0.246
ENSG00000067369 E031 0.3513410 0.0252551838 3.216354e-01   15 43441259 43441525 267 - 0.000 0.184 10.686
ENSG00000067369 E032 41.0648976 0.0008059021 4.358568e-01 0.794961124 15 43441526 43441583 58 - 1.636 1.594 -0.140
ENSG00000067369 E033 72.4273078 0.0040331136 3.224774e-01 0.718785780 15 43446387 43446532 146 - 1.885 1.836 -0.165
ENSG00000067369 E034 48.6672326 0.0005788224 3.593116e-01 0.746437840 15 43446533 43446590 58 - 1.706 1.662 -0.150
ENSG00000067369 E035 8.5307405 0.2868312573 3.304421e-01 0.724955901 15 43446766 43446910 145 - 0.862 1.016 0.579
ENSG00000067369 E036 3.2700428 0.3252538758 8.220288e-01 0.955002906 15 43446911 43446914 4 - 0.637 0.592 -0.196
ENSG00000067369 E037 6.8064735 0.1909937294 7.589019e-01 0.935499575 15 43447155 43447365 211 - 0.851 0.885 0.130
ENSG00000067369 E038 53.6882570 0.0005561555 1.887169e-01 0.590061738 15 43447366 43447485 120 - 1.763 1.703 -0.206
ENSG00000067369 E039 272.4089827 0.0011416043 2.957673e-01 0.696232829 15 43455892 43457218 1327 - 2.406 2.433 0.090
ENSG00000067369 E040 57.3096648 0.0075707993 9.561292e-02 0.449445576 15 43469858 43470066 209 - 1.814 1.710 -0.351
ENSG00000067369 E041 0.0000000       15 43470717 43470776 60 -      
ENSG00000067369 E042 34.0361190 0.0010361905 2.805700e-02 0.271555208 15 43474673 43474767 95 - 1.608 1.478 -0.443
ENSG00000067369 E043 33.5326811 0.0009250716 3.656590e-01 0.750660066 15 43475565 43475694 130 - 1.560 1.508 -0.181
ENSG00000067369 E044 44.2785513 0.0006204961 1.024190e-01 0.461811923 15 43477593 43477759 167 - 1.693 1.609 -0.284
ENSG00000067369 E045 43.8231810 0.0007269151 9.686800e-01 0.992714424 15 43479397 43479526 130 - 1.632 1.636 0.015
ENSG00000067369 E046 45.6232296 0.0098405374 2.776638e-01 0.681061950 15 43479859 43480017 159 - 1.599 1.681 0.277
ENSG00000067369 E047 40.8382926 0.0007051139 7.156477e-02 0.398973217 15 43480895 43481022 128 - 1.537 1.642 0.355
ENSG00000067369 E048 38.8785770 0.0030738476 4.508592e-01 0.804078613 15 43491669 43491753 85 - 1.557 1.606 0.166
ENSG00000067369 E049 38.0078571 0.0007461743 3.946306e-01 0.769728694 15 43492002 43492095 94 - 1.547 1.597 0.173
ENSG00000067369 E050 36.9097095 0.0015340031 1.479813e-01 0.536360497 15 43492284 43492468 185 - 1.508 1.597 0.307
ENSG00000067369 E051 13.6470983 0.0197000007 9.596975e-01 0.990717692 15 43493037 43493156 120 - 1.149 1.145 -0.015
ENSG00000067369 E052 0.1544607 0.0330667247 6.837584e-01   15 43497438 43497538 101 - 0.000 0.102 9.625
ENSG00000067369 E053 1.4151054 0.3593107872 8.515874e-01   15 43510370 43510728 359 - 0.324 0.413 0.522