ENSG00000066117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394963 ENSG00000066117 HEK293_DMSO_6hA HEK293_OSMI2_6hA SMARCD1 protein_coding protein_coding 97.90893 88.83043 134.0654 8.013927 18.80789 0.5937561 53.677097 42.051378 77.89976 3.457133 12.510876 0.8893079 0.5660208 0.47450000 0.57706667 0.10256667 0.008764219 0.008764219 FALSE TRUE
ENST00000548573 ENSG00000066117 HEK293_DMSO_6hA HEK293_OSMI2_6hA SMARCD1 protein_coding protein_coding 97.90893 88.83043 134.0654 8.013927 18.80789 0.5937561 24.669765 26.193169 29.26525 4.164181 5.271477 0.1599400 0.2280875 0.29216667 0.21683333 -0.07533333 0.257070125 0.008764219 FALSE TRUE
ENST00000551966 ENSG00000066117 HEK293_DMSO_6hA HEK293_OSMI2_6hA SMARCD1 protein_coding protein_coding 97.90893 88.83043 134.0654 8.013927 18.80789 0.5937561 7.612675 3.387498 10.87011 1.716147 2.249010 1.6791483 0.0766625 0.03493333 0.07936667 0.04443333 0.746896605 0.008764219 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000066117 E001 0.4716622 1.343634e-01 0.4176663600   12 50084853 50085199 347 + 0.101 0.246 1.534
ENSG00000066117 E002 2.0518861 4.669165e-02 0.1596527163 0.55380259 12 50085200 50085305 106 + 0.591 0.329 -1.356
ENSG00000066117 E003 1.4481996 2.491562e-01 0.5753420081   12 50085306 50085310 5 + 0.450 0.326 -0.704
ENSG00000066117 E004 1.8528056 1.384791e-01 0.6036540298 0.87722018 12 50085311 50085316 6 + 0.521 0.398 -0.625
ENSG00000066117 E005 6.1752845 1.301993e-01 0.1611859928 0.55594808 12 50085317 50085324 8 + 0.957 0.675 -1.108
ENSG00000066117 E006 7.0752581 8.642880e-02 0.0980847752 0.45370756 12 50085325 50085327 3 + 1.009 0.710 -1.159
ENSG00000066117 E007 48.1191611 1.543321e-03 0.0111194491 0.18254597 12 50085328 50085341 14 + 1.742 1.606 -0.463
ENSG00000066117 E008 59.9894604 7.792203e-04 0.0025453370 0.09031804 12 50085342 50085352 11 + 1.836 1.694 -0.480
ENSG00000066117 E009 417.7076077 2.365598e-03 0.0006967533 0.04430446 12 50085353 50085546 194 + 2.659 2.562 -0.323
ENSG00000066117 E010 8.1019542 3.521413e-01 0.4122773274 0.78194657 12 50085683 50085870 188 + 0.898 1.007 0.407
ENSG00000066117 E011 736.9254876 1.536711e-03 0.0010606408 0.05613470 12 50086161 50086348 188 + 2.894 2.823 -0.239
ENSG00000066117 E012 438.2421468 1.197830e-04 0.0342453059 0.29474655 12 50086621 50086663 43 + 2.652 2.617 -0.117
ENSG00000066117 E013 680.7610794 8.003908e-05 0.1358038287 0.51915742 12 50086756 50086878 123 + 2.836 2.817 -0.063
ENSG00000066117 E014 8.0752268 4.053086e-02 0.0177562515 0.22487427 12 50086879 50086917 39 + 0.767 1.104 1.271
ENSG00000066117 E015 625.4361653 1.808294e-04 0.0185525278 0.22887186 12 50087363 50087485 123 + 2.807 2.772 -0.116
ENSG00000066117 E016 15.8853433 4.907728e-03 0.0648072541 0.38389738 12 50088235 50088290 56 + 1.132 1.299 0.594
ENSG00000066117 E017 327.0869631 3.931802e-04 0.2368882185 0.64184355 12 50088521 50088524 4 + 2.522 2.498 -0.080
ENSG00000066117 E018 668.7142256 2.707495e-04 0.9706345681 0.99314851 12 50088525 50088637 113 + 2.820 2.821 0.004
ENSG00000066117 E019 52.4992511 2.196765e-01 0.0124751216 0.19265873 12 50088638 50089422 785 + 1.453 1.925 1.602
ENSG00000066117 E020 641.1224676 1.411322e-03 0.8222652391 0.95500315 12 50089884 50089985 102 + 2.805 2.801 -0.013
ENSG00000066117 E021 853.3410371 2.332201e-03 0.6518407405 0.89735479 12 50090241 50090402 162 + 2.933 2.921 -0.039
ENSG00000066117 E022 766.7723831 2.249633e-04 0.4710595614 0.81431320 12 50090493 50090590 98 + 2.872 2.884 0.041
ENSG00000066117 E023 834.3613116 1.212070e-03 0.6226800901 0.88523499 12 50094437 50094505 69 + 2.911 2.922 0.039
ENSG00000066117 E024 852.2032286 7.415987e-04 0.5352469950 0.84755795 12 50094506 50094572 67 + 2.928 2.919 -0.029
ENSG00000066117 E025 9.0570646 4.360486e-02 0.0457215234 0.33204719 12 50096659 50096849 191 + 0.840 1.131 1.080
ENSG00000066117 E026 949.3961590 2.472316e-04 0.6629652062 0.90147622 12 50096850 50096972 123 + 2.967 2.975 0.028
ENSG00000066117 E027 31.4759492 8.715974e-02 0.0795879291 0.41681552 12 50098495 50098713 219 + 1.384 1.623 0.821
ENSG00000066117 E028 916.8665838 8.951767e-05 0.1244851908 0.50136877 12 50098714 50098815 102 + 2.947 2.968 0.070
ENSG00000066117 E029 1180.4184552 8.871731e-05 0.1762147904 0.57452023 12 50098947 50099141 195 + 3.058 3.075 0.056
ENSG00000066117 E030 1409.9166993 7.417182e-04 0.7140497662 0.92006837 12 50099142 50099429 288 + 3.138 3.151 0.040
ENSG00000066117 E031 781.8562286 1.014412e-03 0.5930794673 0.87265677 12 50099430 50099486 57 + 2.880 2.897 0.057
ENSG00000066117 E032 932.1819645 7.532758e-04 0.8851273614 0.97260416 12 50099487 50099565 79 + 2.961 2.968 0.026
ENSG00000066117 E033 1433.9164823 1.111183e-03 0.6794829219 0.90797719 12 50099566 50099799 234 + 3.153 3.151 -0.007
ENSG00000066117 E034 965.7912758 9.626945e-04 0.6709619918 0.90458799 12 50099800 50099900 101 + 2.975 2.986 0.036
ENSG00000066117 E035 1163.9742001 1.543570e-03 0.5644160123 0.85963192 12 50099901 50100053 153 + 3.055 3.071 0.056
ENSG00000066117 E036 1639.6435300 1.166038e-03 0.0134296954 0.19980440 12 50100054 50100707 654 + 3.190 3.237 0.157