ENSG00000065357

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000546878 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding protein_coding 3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.5812409 0.75625760 0.7633382 0.01236052 0.08450707 0.01327003 0.15282917 0.13443333 0.13623333 0.00180000 9.986915e-01 9.623567e-05   FALSE
ENST00000546995 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding retained_intron 3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.1357316 0.06861197 0.1591077 0.06861197 0.08126604 1.10512152 0.05244167 0.01130000 0.03026667 0.01896667 7.466831e-01 9.623567e-05 FALSE FALSE
ENST00000548491 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding retained_intron 3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.1021840 0.51814779 0.0000000 0.14894993 0.00000000 -5.72286978 0.02407917 0.09016667 0.00000000 -0.09016667 9.623567e-05 9.623567e-05   FALSE
ENST00000549079 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding processed_transcript 3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.4480833 0.38525810 0.2793989 0.20021033 0.27939893 -0.44973545 0.13777500 0.07110000 0.05933333 -0.01176667 7.462956e-01 9.623567e-05 FALSE TRUE
ENST00000552903 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding protein_coding 3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.4574976 1.03681028 1.1000298 0.25515331 0.55033888 0.08459846 0.09086250 0.18230000 0.18220000 -0.00010000 9.010126e-01 9.623567e-05 FALSE FALSE
MSTRG.7433.17 ENSG00000065357 HEK293_DMSO_6hA HEK293_OSMI2_6hA DGKA protein_coding   3.660498 5.639879 5.594884 0.214642 0.4496549 -0.01153534 0.9835820 1.35785223 1.7299088 0.30807823 0.28088970 0.34709927 0.23822083 0.23766667 0.31610000 0.07843333 7.479615e-01 9.623567e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000065357 E001 18.7251845 0.001682328 0.1925328587 0.59456675 12 55927319 55927619 301 + 1.231 1.340 0.381
ENSG00000065357 E002 2.6504549 0.017765816 0.8775346597 0.97059765 12 55928255 55928334 80 + 0.577 0.557 -0.091
ENSG00000065357 E003 0.0000000       12 55930428 55930643 216 +      
ENSG00000065357 E004 0.1767706 0.032880448 0.5018321623   12 55931089 55931161 73 + 0.117 0.000 -13.635
ENSG00000065357 E005 0.1767706 0.032880448 0.5018321623   12 55931162 55931163 2 + 0.117 0.000 -13.635
ENSG00000065357 E006 0.1767706 0.032880448 0.5018321623   12 55931164 55931171 8 + 0.117 0.000 -13.635
ENSG00000065357 E007 0.8045307 0.016714567 0.6895702943   12 55931172 55931191 20 + 0.284 0.218 -0.505
ENSG00000065357 E008 0.8045307 0.016714567 0.6895702943   12 55931192 55931214 23 + 0.284 0.218 -0.505
ENSG00000065357 E009 1.4714328 0.033140267 0.7880263759   12 55931215 55931298 84 + 0.407 0.362 -0.253
ENSG00000065357 E010 1.5356868 0.201396635 0.8086576221   12 55931299 55931344 46 + 0.419 0.360 -0.332
ENSG00000065357 E011 0.0000000       12 55931453 55931471 19 +      
ENSG00000065357 E012 0.0000000       12 55931472 55931496 25 +      
ENSG00000065357 E013 0.3607829 0.032544998 0.9803606905   12 55931789 55932027 239 + 0.117 0.123 0.079
ENSG00000065357 E014 0.1795728 0.034056414 0.4723648767   12 55932028 55932048 21 + 0.000 0.123 13.290
ENSG00000065357 E015 0.3513410 0.027442404 0.1911293630   12 55932049 55932050 2 + 0.000 0.218 14.254
ENSG00000065357 E016 0.5231092 0.024306378 0.0792934416   12 55932051 55932051 1 + 0.000 0.296 14.807
ENSG00000065357 E017 0.8493381 0.016730919 0.0154622399   12 55932052 55932057 6 + 0.000 0.420 15.496
ENSG00000065357 E018 1.1386252 0.013696863 0.2356366559   12 55932058 55932062 5 + 0.208 0.420 1.404
ENSG00000065357 E019 1.1386252 0.013696863 0.2356366559   12 55932063 55932063 1 + 0.208 0.420 1.404
ENSG00000065357 E020 3.7737954 0.005651325 0.2633782722 0.66828184 12 55932064 55932094 31 + 0.577 0.745 0.718
ENSG00000065357 E021 4.4116213 0.005400800 0.5054390758 0.83239718 12 55932095 55932107 13 + 0.672 0.770 0.402
ENSG00000065357 E022 5.1002703 0.004746610 0.5281846623 0.84413113 12 55932108 55932123 16 + 0.726 0.816 0.359
ENSG00000065357 E023 0.3262289 0.027442404 0.1911341326   12 55932124 55932134 11 + 0.000 0.218 14.253
ENSG00000065357 E024 0.6797700 0.052742428 0.9667980883   12 55932135 55932162 28 + 0.210 0.218 0.069
ENSG00000065357 E025 0.6797700 0.052742428 0.9667980883   12 55932163 55932180 18 + 0.210 0.218 0.069
ENSG00000065357 E026 1.7109712 0.010461328 0.1480652585 0.53647635 12 55932181 55932255 75 + 0.540 0.296 -1.336
ENSG00000065357 E027 0.0000000       12 55932561 55932706 146 +      
ENSG00000065357 E028 0.1125166 0.033149274 0.5026188598   12 55932707 55932909 203 + 0.116 0.000 -13.630
ENSG00000065357 E029 0.1544607 0.034186125 0.4723881933   12 55933505 55933608 104 + 0.000 0.122 13.288
ENSG00000065357 E030 0.6637786 0.190205296 0.7994649719   12 55935305 55935335 31 + 0.276 0.217 -0.447
ENSG00000065357 E031 0.8449887 0.031809309 0.4547817310   12 55935336 55935404 69 + 0.347 0.218 -0.911
ENSG00000065357 E032 0.6293974 0.054356350 0.3387302123   12 55935405 55935833 429 + 0.285 0.122 -1.511
ENSG00000065357 E033 0.4465501 0.022008535 0.5441691216   12 55935834 55935958 125 + 0.116 0.218 1.084
ENSG00000065357 E034 0.8260439 0.277259714 0.8648133668   12 55935959 55936146 188 + 0.273 0.295 0.154
ENSG00000065357 E035 0.7151646 0.123062693 0.7128366731   12 55936147 55936422 276 + 0.282 0.217 -0.496
ENSG00000065357 E036 9.1399533 0.003441164 0.0491671173 0.34204606 12 55936423 55936447 25 + 1.084 0.876 -0.772
ENSG00000065357 E037 15.0300147 0.013210560 0.0683111606 0.39209072 12 55936448 55936567 120 + 1.280 1.104 -0.624
ENSG00000065357 E038 0.1544607 0.034186125 0.4723881933   12 55936568 55936652 85 + 0.000 0.122 13.288
ENSG00000065357 E039 0.3089214 0.390747673 0.2836400475   12 55936653 55936856 204 + 0.000 0.215 13.761
ENSG00000065357 E040 0.0000000       12 55936857 55937016 160 +      
ENSG00000065357 E041 9.3118195 0.002785751 0.0077229446 0.15423373 12 55937017 55937030 14 + 1.135 0.857 -1.029
ENSG00000065357 E042 13.3617512 0.002852073 0.0030194598 0.09892283 12 55937031 55937090 60 + 1.262 0.991 -0.975
ENSG00000065357 E043 22.9669326 0.001829817 0.4007536784 0.77380750 12 55937408 55937524 117 + 1.399 1.346 -0.183
ENSG00000065357 E044 14.4656894 0.001963946 0.9796995714 0.99513526 12 55937525 55937543 19 + 1.181 1.186 0.017
ENSG00000065357 E045 0.2937266 0.027442404 0.2097138795   12 55937544 55937557 14 + 0.208 0.000 -14.585
ENSG00000065357 E046 17.8951072 0.001763356 0.4070991620 0.77827740 12 55937978 55938024 47 + 1.297 1.238 -0.207
ENSG00000065357 E047 16.6225914 0.001791543 0.4544301594 0.80586784 12 55938025 55938052 28 + 1.276 1.221 -0.191
ENSG00000065357 E048 1.6885712 0.082448388 0.2251551345 0.63019783 12 55938053 55938258 206 + 0.288 0.515 1.277
ENSG00000065357 E049 2.3358390 0.047542571 0.9370540730 0.98514959 12 55938259 55938510 252 + 0.503 0.516 0.059
ENSG00000065357 E050 17.4926842 0.001666394 0.3548368941 0.74317071 12 55938511 55938552 42 + 1.297 1.230 -0.236
ENSG00000065357 E051 11.7127922 0.002981095 0.1948803665 0.59767472 12 55938553 55938560 8 + 1.163 1.045 -0.424
ENSG00000065357 E052 3.2454935 0.560984318 0.4257157554 0.78962743 12 55938561 55938637 77 + 0.615 0.626 0.049
ENSG00000065357 E053 2.3470088 0.221767451 0.7864992348 0.94408508 12 55938638 55938651 14 + 0.513 0.516 0.014
ENSG00000065357 E054 3.0044689 0.244571310 0.5316309439 0.84592939 12 55938652 55938689 38 + 0.557 0.627 0.313
ENSG00000065357 E055 2.1373214 0.181911719 0.7067626551 0.91766451 12 55938690 55938698 9 + 0.464 0.513 0.243
ENSG00000065357 E056 2.0248049 0.385451611 0.4940423291 0.82633271 12 55938699 55938747 49 + 0.426 0.512 0.434
ENSG00000065357 E057 2.5696219 0.870990693 0.7381443753 0.92843642 12 55938748 55938802 55 + 0.620 0.465 -0.721
ENSG00000065357 E058 3.8577054 0.411632505 0.4895987604 0.82438971 12 55938803 55938914 112 + 0.639 0.716 0.326
ENSG00000065357 E059 13.1940670 0.002551423 0.6951510996 0.91343875 12 55938915 55938937 23 + 1.134 1.176 0.151
ENSG00000065357 E060 9.6560554 0.002780075 0.5983301754 0.87497866 12 55938938 55938938 1 + 0.997 1.058 0.224
ENSG00000065357 E061 14.9861302 0.009517054 0.8650368751 0.96709231 12 55938939 55938989 51 + 1.213 1.204 -0.031
ENSG00000065357 E062 2.3241970 0.010366221 0.0957136417 0.44964139 12 55938990 55939185 196 + 0.349 0.629 1.401
ENSG00000065357 E063 18.8402427 0.024316529 0.9722040943 0.99342022 12 55939186 55939280 95 + 1.296 1.307 0.039
ENSG00000065357 E064 12.0390563 0.011934992 0.5746235846 0.86427669 12 55939281 55939305 25 + 1.081 1.148 0.241
ENSG00000065357 E065 17.2327798 0.002178094 0.3385507606 0.73094693 12 55939415 55939474 60 + 1.215 1.299 0.297
ENSG00000065357 E066 13.2841728 0.009980702 0.1694781175 0.56654192 12 55939475 55939486 12 + 1.071 1.214 0.509
ENSG00000065357 E067 17.0072962 0.019035271 0.3231303735 0.71927590 12 55939487 55939529 43 + 1.197 1.301 0.365
ENSG00000065357 E068 6.0531559 0.190595208 0.1095734998 0.47488213 12 55939530 55939914 385 + 0.658 0.964 1.207
ENSG00000065357 E069 3.8510048 0.240689134 0.3187540293 0.71561611 12 55939915 55940081 167 + 0.596 0.743 0.621
ENSG00000065357 E070 18.5326828 0.001538999 0.7578809516 0.93513718 12 55940082 55940168 87 + 1.276 1.306 0.106
ENSG00000065357 E071 9.6974299 0.003599524 0.5598025724 0.85793147 12 55940169 55940170 2 + 1.059 1.006 -0.197
ENSG00000065357 E072 2.6899823 0.007814427 0.2877172932 0.68970655 12 55940171 55940251 81 + 0.455 0.629 0.815
ENSG00000065357 E073 3.9579560 0.008020371 0.0900439810 0.43855639 12 55940252 55940313 62 + 0.540 0.793 1.078
ENSG00000065357 E074 23.4444498 0.001250699 0.4211851184 0.78686609 12 55940314 55940433 120 + 1.354 1.417 0.219
ENSG00000065357 E075 2.3141312 0.008196958 0.0252455498 0.25952900 12 55940434 55940623 190 + 0.284 0.661 1.955
ENSG00000065357 E076 21.6218655 0.015469583 0.1355449237 0.51869151 12 55940624 55940722 99 + 1.280 1.421 0.490
ENSG00000065357 E077 1.1978159 0.013886830 0.2362354006   12 55940723 55940896 174 + 0.209 0.420 1.400
ENSG00000065357 E078 17.2999998 0.060067983 0.6333677857 0.88937034 12 55940897 55940974 78 + 1.228 1.303 0.261
ENSG00000065357 E079 11.2766518 0.068757354 0.9312215411 0.98361702 12 55940975 55940980 6 + 1.103 1.091 -0.046
ENSG00000065357 E080 6.0136040 0.007406466 0.0001598669 0.01777945 12 55940981 55941251 271 + 0.500 1.019 2.128
ENSG00000065357 E081 13.7228283 0.027080026 0.4856788217 0.82231621 12 55941252 55941284 33 + 1.206 1.135 -0.255
ENSG00000065357 E082 13.8691770 0.027428054 0.6718884751 0.90488608 12 55941285 55941325 41 + 1.188 1.146 -0.151
ENSG00000065357 E083 2.0011816 0.015733038 0.6152403954 0.88226656 12 55941326 55941326 1 + 0.501 0.420 -0.413
ENSG00000065357 E084 18.0972647 0.013124097 0.5483441001 0.85332500 12 55941510 55941584 75 + 1.236 1.300 0.224
ENSG00000065357 E085 27.9659983 0.013180644 0.9216016020 0.98125065 12 55941998 55942083 86 + 1.445 1.460 0.051
ENSG00000065357 E086 0.5231092 0.024306378 0.0792934416   12 55942084 55942173 90 + 0.000 0.296 14.807
ENSG00000065357 E087 30.4558609 0.034286579 0.8281340660 0.95643257 12 55942174 55942263 90 + 1.495 1.491 -0.012
ENSG00000065357 E088 0.8716480 0.082087745 0.1855790487   12 55942264 55942648 385 + 0.117 0.363 2.078
ENSG00000065357 E089 0.9338793 0.165639387 0.9792682620   12 55943297 55943420 124 + 0.286 0.294 0.053
ENSG00000065357 E090 42.7832710 0.006816798 0.6721565892 0.90492639 12 55951623 55951783 161 + 1.645 1.625 -0.069
ENSG00000065357 E091 3.2208961 0.007079501 0.0937535587 0.44550953 12 55951784 55952034 251 + 0.455 0.719 1.195
ENSG00000065357 E092 30.7608979 0.001065854 0.6986110686 0.91453649 12 55952035 55952099 65 + 1.499 1.482 -0.059
ENSG00000065357 E093 3.3342140 0.090558788 0.9965107852 0.99913964 12 55952100 55952340 241 + 0.645 0.628 -0.074
ENSG00000065357 E094 31.8322451 0.012489614 0.2346438586 0.63963481 12 55952341 55952431 91 + 1.550 1.464 -0.295
ENSG00000065357 E095 3.7866024 0.005860377 0.4790018530 0.81868797 12 55952432 55952733 302 + 0.611 0.719 0.458
ENSG00000065357 E096 44.5231910 0.001206607 0.0067448903 0.14476664 12 55952734 55952927 194 + 1.711 1.574 -0.465
ENSG00000065357 E097 17.4288498 0.010565971 0.2197390820 0.62434029 12 55952928 55952932 5 + 1.308 1.196 -0.396
ENSG00000065357 E098 32.3101896 0.005713626 0.1389498573 0.52368241 12 55953040 55953160 121 + 1.561 1.463 -0.336
ENSG00000065357 E099 1.8066923 0.009802931 0.0260811085 0.26253641 12 55953204 55953349 146 + 0.208 0.595 2.251
ENSG00000065357 E100 22.4880592 0.008401244 0.5411135237 0.85041691 12 55953350 55953410 61 + 1.345 1.401 0.193
ENSG00000065357 E101 4.0930460 0.107211570 0.2812104675 0.68429845 12 55953411 55953684 274 + 0.589 0.772 0.773
ENSG00000065357 E102 30.0190254 0.016648188 0.3567451275 0.74458368 12 55953685 55954027 343 + 1.442 1.533 0.314