ENSG00000063854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397353 ENSG00000063854 HEK293_DMSO_6hA HEK293_OSMI2_6hA HAGH protein_coding protein_coding 74.69565 78.84095 109.5854 8.034581 15.82024 0.4749879 12.587525 12.661803 18.42275 2.3784124 2.658994 0.5406498 0.15608333 0.1591333 0.1681 0.008966667 0.85158626 0.01171624 FALSE TRUE
ENST00000564445 ENSG00000063854 HEK293_DMSO_6hA HEK293_OSMI2_6hA HAGH protein_coding protein_coding 74.69565 78.84095 109.5854 8.034581 15.82024 0.4749879 27.834904 33.049543 31.41485 5.1259820 3.671309 -0.0731609 0.39828333 0.4177000 0.2892 -0.128500000 0.03917743 0.01171624 FALSE TRUE
MSTRG.11800.10 ENSG00000063854 HEK293_DMSO_6hA HEK293_OSMI2_6hA HAGH protein_coding   74.69565 78.84095 109.5854 8.034581 15.82024 0.4749879 7.095617 6.777287 10.71910 0.6040412 1.906066 0.6606218 0.08956667 0.0863000 0.0968 0.010500000 0.72829477 0.01171624 FALSE TRUE
MSTRG.11800.3 ENSG00000063854 HEK293_DMSO_6hA HEK293_OSMI2_6hA HAGH protein_coding   74.69565 78.84095 109.5854 8.034581 15.82024 0.4749879 16.675871 14.046368 32.83563 2.6347300 6.253930 1.2244776 0.20780417 0.1765333 0.2953 0.118766667 0.01171624 0.01171624 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000063854 E001 0.8643453 4.636404e-01 0.9495328190   16 1795620 1795720 101 - 0.273 0.239 -0.254
ENSG00000063854 E002 1.4295496 1.710253e-02 0.9150888153   16 1806803 1806880 78 - 0.374 0.393 0.106
ENSG00000063854 E003 4.2231112 4.977237e-03 0.5649929152 0.85992696 16 1807577 1807628 52 - 0.751 0.670 -0.336
ENSG00000063854 E004 12.5129331 2.156502e-03 0.2957988362 0.69628719 16 1807629 1807764 136 - 1.166 1.067 -0.358
ENSG00000063854 E005 17.4828706 1.676562e-03 0.3543084716 0.74276530 16 1807765 1807948 184 - 1.292 1.216 -0.267
ENSG00000063854 E006 37.8347901 7.509389e-04 0.0182845558 0.22750529 16 1807949 1808869 921 - 1.650 1.514 -0.465
ENSG00000063854 E007 3.5168303 1.323352e-02 0.2118348803 0.61637662 16 1808870 1808871 2 - 0.750 0.553 -0.846
ENSG00000063854 E008 13.2377204 2.190330e-03 0.0184711519 0.22847535 16 1808872 1809025 154 - 1.247 1.024 -0.800
ENSG00000063854 E009 10.5071000 2.073294e-02 0.1591564449 0.55302276 16 1809026 1809102 77 - 1.131 0.959 -0.625
ENSG00000063854 E010 8.5231650 5.635441e-02 0.1360912792 0.51941029 16 1809103 1809104 2 - 1.069 0.841 -0.856
ENSG00000063854 E011 8.8196939 3.796222e-02 0.1143643401 0.48314087 16 1809105 1809106 2 - 1.080 0.863 -0.809
ENSG00000063854 E012 37.9534788 1.174226e-02 0.8664318859 0.96729915 16 1809107 1809123 17 - 1.594 1.600 0.021
ENSG00000063854 E013 229.9156723 1.647182e-04 0.1044800352 0.46579630 16 1809124 1809237 114 - 2.346 2.384 0.125
ENSG00000063854 E014 708.0267592 1.231164e-04 0.0874508078 0.43309322 16 1809238 1809382 145 - 2.840 2.863 0.076
ENSG00000063854 E015 54.3833972 6.706582e-04 0.3256089246 0.72131263 16 1809383 1809446 64 - 1.762 1.714 -0.163
ENSG00000063854 E016 735.8397718 6.755362e-05 0.5254957576 0.84283732 16 1809754 1809833 80 - 2.863 2.871 0.027
ENSG00000063854 E017 4.8468438 9.304905e-02 0.9559077019 0.98989492 16 1809834 1810887 1054 - 0.756 0.764 0.029
ENSG00000063854 E018 0.6920751 4.106259e-01 0.4111372807   16 1812359 1812419 61 - 0.107 0.325 1.986
ENSG00000063854 E019 876.1243913 1.467264e-04 0.1876147014 0.58876062 16 1816893 1816994 102 - 2.934 2.951 0.057
ENSG00000063854 E020 509.1003716 1.559677e-03 0.6544304431 0.89834505 16 1817168 1817188 21 - 2.697 2.715 0.059
ENSG00000063854 E021 770.3431914 1.421068e-04 0.7781343862 0.94180892 16 1817189 1817271 83 - 2.884 2.888 0.014
ENSG00000063854 E022 33.5027663 1.021285e-01 0.0471156352 0.33626862 16 1818515 1819114 600 - 1.377 1.669 0.999
ENSG00000063854 E023 723.4014585 1.155892e-04 0.7622164799 0.93657320 16 1819115 1819223 109 - 2.856 2.861 0.016
ENSG00000063854 E024 2.2980132 8.413916e-03 0.7506571478 0.93271853 16 1819835 1819835 1 - 0.503 0.553 0.239
ENSG00000063854 E025 6.5351079 7.379191e-02 0.2369194180 0.64186512 16 1819836 1819896 61 - 0.798 0.974 0.673
ENSG00000063854 E026 874.0877374 9.098463e-05 0.4770720595 0.81780881 16 1819897 1820014 118 - 2.944 2.936 -0.026
ENSG00000063854 E027 50.4309118 2.172414e-02 0.0188358507 0.23012791 16 1821512 1822299 788 - 1.604 1.805 0.684
ENSG00000063854 E028 668.1105104 8.246472e-05 0.8305185304 0.95693884 16 1822300 1822364 65 - 2.826 2.823 -0.010
ENSG00000063854 E029 796.3013136 3.124126e-04 0.1145500860 0.48345720 16 1822865 1823037 173 - 2.909 2.890 -0.066
ENSG00000063854 E030 58.9096776 9.231630e-03 0.1175523848 0.48912713 16 1826507 1826602 96 - 1.813 1.715 -0.329
ENSG00000063854 E031 5.7037257 4.011005e-03 0.8108734964 0.95171707 16 1826603 1826711 109 - 0.845 0.814 -0.122
ENSG00000063854 E032 268.8420130 1.112142e-03 0.0001982222 0.02040199 16 1826712 1826940 229 - 2.473 2.376 -0.324
ENSG00000063854 E033 23.9744032 5.863535e-03 0.4946330955 0.82661163 16 1826941 1828997 2057 - 1.369 1.421 0.180