ENSG00000063241

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000425675 ENSG00000063241 HEK293_DMSO_6hA HEK293_OSMI2_6hA ISOC2 protein_coding protein_coding 79.06707 63.64336 121.376 9.294112 28.4022 0.931293 34.81742 21.50813 54.29218 3.386005 13.069741 1.3354575 0.4350250 0.3369000 0.4460667 0.10916667 8.084022e-06 8.084022e-06 FALSE TRUE
ENST00000438389 ENSG00000063241 HEK293_DMSO_6hA HEK293_OSMI2_6hA ISOC2 protein_coding protein_coding 79.06707 63.64336 121.376 9.294112 28.4022 0.931293 13.50613 14.89077 24.13446 2.037067 4.877171 0.6963053 0.1619208 0.2351667 0.2029333 -0.03223333 4.518261e-01 8.084022e-06 FALSE FALSE
MSTRG.17716.1 ENSG00000063241 HEK293_DMSO_6hA HEK293_OSMI2_6hA ISOC2 protein_coding   79.06707 63.64336 121.376 9.294112 28.4022 0.931293 25.80249 21.03086 36.09987 3.497218 10.131511 0.7791998 0.3279167 0.3280667 0.2877333 -0.04033333 6.419263e-01 8.084022e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000063241 E001 1.458117 1.138215e-02 0.0642432283   19 55452978 55452984 7 - 0.498 0.153 -2.349
ENSG00000063241 E002 2.837204 7.349390e-03 0.8039409487 0.94954526 19 55452985 55452988 4 - 0.559 0.596 0.167
ENSG00000063241 E003 1672.741703 6.229098e-04 0.0750025806 0.40691590 19 55452989 55453388 400 - 3.202 3.233 0.101
ENSG00000063241 E004 10.638008 1.861098e-01 0.0880728802 0.43434999 19 55453389 55453584 196 - 0.890 1.230 1.244
ENSG00000063241 E005 16.233606 6.029953e-02 0.0001554500 0.01752455 19 55453899 55454988 1090 - 0.917 1.476 1.994
ENSG00000063241 E006 561.292512 1.020647e-04 0.5757708785 0.86474096 19 55454989 55454989 1 - 2.742 2.746 0.015
ENSG00000063241 E007 645.190814 1.265007e-04 0.3340388934 0.72763334 19 55454990 55455001 12 - 2.800 2.810 0.035
ENSG00000063241 E008 1054.360311 1.843527e-04 0.9908828000 0.99775637 19 55455002 55455106 105 - 3.017 3.016 -0.004
ENSG00000063241 E009 5.668833 2.541903e-02 0.9736653847 0.99377473 19 55455107 55455259 153 - 0.812 0.812 -0.002
ENSG00000063241 E010 1084.356962 6.929192e-05 0.6436059194 0.89375243 19 55455260 55455330 71 - 3.029 3.031 0.004
ENSG00000063241 E011 108.836926 2.893861e-04 0.9601636485 0.99083312 19 55455331 55455331 1 - 2.036 2.033 -0.011
ENSG00000063241 E012 149.208150 2.544583e-04 0.2627265782 0.66788732 19 55455332 55455378 47 - 2.160 2.188 0.095
ENSG00000063241 E013 30.382322 1.640613e-01 0.0296445577 0.27812845 19 55455379 55455635 257 - 1.267 1.693 1.466
ENSG00000063241 E014 1009.524351 1.490584e-03 0.0106907520 0.17900588 19 55455636 55455845 210 - 3.013 2.968 -0.149
ENSG00000063241 E015 20.256853 9.049111e-02 0.0047201109 0.12319497 19 55455897 55456348 452 - 1.068 1.537 1.645
ENSG00000063241 E016 1528.921582 8.828003e-05 0.2491498580 0.65465344 19 55456349 55456489 141 - 3.183 3.171 -0.043
ENSG00000063241 E017 15.292310 1.848691e-03 0.2995582800 0.69954753 19 55457092 55457212 121 - 1.177 1.262 0.298
ENSG00000063241 E018 3.944911 6.459547e-02 0.0002695586 0.02463777 19 55459717 55460031 315 - 0.295 0.956 3.048
ENSG00000063241 E019 1147.196386 5.889678e-04 0.0410100001 0.31749610 19 55461512 55462547 1036 - 3.062 3.036 -0.085