ENSG00000062194

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309096 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding retained_intron 30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 1.45176520 2.0706939 0.7822644 0.7077304 0.1196837 -1.3930109 0.073425000 0.22736667 0.08790000 -0.139466667 0.01691417 0.01691417 FALSE FALSE
ENST00000424459 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding protein_coding 30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 7.28710933 1.0002481 2.2976959 0.2333681 0.9399783 1.1917434 0.197733333 0.11686667 0.20960000 0.092733333 0.68356507 0.01691417 FALSE TRUE
ENST00000506184 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding protein_coding 30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 3.90994789 1.8712852 0.9262664 0.6646887 0.5029245 -1.0067276 0.144050000 0.20323333 0.11223333 -0.091000000 0.71839182 0.01691417 FALSE TRUE
ENST00000511209 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding protein_coding 30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 2.35296080 0.6407377 0.7239416 0.2715665 0.3640604 0.1735891 0.078325000 0.06706667 0.06080000 -0.006266667 0.84364977 0.01691417 FALSE TRUE
MSTRG.26229.1 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding   30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 11.14289499 1.2488359 2.8175320 0.5908247 0.9624971 1.1674532 0.294862500 0.12450000 0.26946667 0.144966667 0.20386655 0.01691417 FALSE FALSE
MSTRG.26229.6 ENSG00000062194 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPBP1 protein_coding   30.62839 9.227429 9.681097 3.25691 2.30035 0.06916861 0.03524836 0.0000000 0.2819869 0.0000000 0.2819869 4.8678317 0.006779167 0.00000000 0.05423333 0.054233333 0.78277535 0.01691417 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000062194 E001 0.0000000       5 57173843 57173856 14 +      
ENSG00000062194 E002 0.0000000       5 57173857 57173859 3 +      
ENSG00000062194 E003 0.0000000       5 57173860 57173860 1 +      
ENSG00000062194 E004 1.6999821 0.0102013264 2.835572e-02 2.730829e-01 5 57173861 57173926 66 + 0.601 0.223 -2.157
ENSG00000062194 E005 3.7348337 0.0064714691 1.385709e-01 5.231938e-01 5 57173948 57174048 101 + 0.784 0.566 -0.922
ENSG00000062194 E006 3.9752953 0.0071216029 2.167174e-01 6.214874e-01 5 57174049 57174058 10 + 0.784 0.604 -0.753
ENSG00000062194 E007 7.6978604 0.0264662401 9.790825e-01 9.949698e-01 5 57174059 57174104 46 + 0.955 0.940 -0.057
ENSG00000062194 E008 18.2472881 0.0017650414 3.680592e-01 7.521870e-01 5 57174105 57174211 107 + 1.335 1.265 -0.243
ENSG00000062194 E009 79.1471768 0.0063484586 5.806336e-02 3.664542e-01 5 57175448 57175945 498 + 1.965 1.857 -0.361
ENSG00000062194 E010 80.8273298 0.0009944522 2.270481e-01 6.319727e-01 5 57175946 57176316 371 + 1.949 1.903 -0.156
ENSG00000062194 E011 42.4305786 0.0008701620 1.188581e-01 4.914873e-01 5 57176317 57176400 84 + 1.687 1.608 -0.268
ENSG00000062194 E012 0.1767706 0.1051381521 5.461135e-01   5 57176401 57176415 15 + 0.115 0.000 -8.439
ENSG00000062194 E013 0.0000000       5 57183793 57183796 4 +      
ENSG00000062194 E014 1.5947073 0.0113680692 1.867093e-01   5 57183797 57183918 122 + 0.530 0.302 -1.250
ENSG00000062194 E015 25.3032426 0.0010478263 2.122755e-02 2.415613e-01 5 57214074 57214120 47 + 1.499 1.345 -0.533
ENSG00000062194 E016 44.0208491 0.0007202671 2.971949e-02 2.784096e-01 5 57214121 57214193 73 + 1.717 1.608 -0.373
ENSG00000062194 E017 5.7979837 0.0040270592 7.532091e-01 9.335432e-01 5 57221376 57221396 21 + 0.862 0.826 -0.142
ENSG00000062194 E018 72.0927491 0.0024337614 8.335479e-03 1.592253e-01 5 57230846 57230969 124 + 1.926 1.813 -0.378
ENSG00000062194 E019 57.7145899 0.0012194653 9.254458e-02 4.430757e-01 5 57231098 57231148 51 + 1.810 1.734 -0.255
ENSG00000062194 E020 63.2005679 0.0041104469 3.667361e-01 7.514038e-01 5 57231149 57231223 75 + 1.834 1.788 -0.156
ENSG00000062194 E021 74.2204822 0.0019104783 2.321634e-01 6.372009e-01 5 57231224 57231302 79 + 1.905 1.856 -0.163
ENSG00000062194 E022 44.5606140 0.0042171207 3.341252e-01 7.277190e-01 5 57231303 57231321 19 + 1.691 1.641 -0.171
ENSG00000062194 E023 54.9883860 0.0007184111 2.409985e-01 6.461030e-01 5 57235966 57236023 58 + 1.786 1.734 -0.175
ENSG00000062194 E024 32.2683264 0.0010538387 3.804762e-01 7.603789e-01 5 57236024 57236032 9 + 1.563 1.512 -0.176
ENSG00000062194 E025 0.9467473 0.0388928134 9.245067e-01   5 57237041 57237112 72 + 0.279 0.302 0.157
ENSG00000062194 E026 22.8720328 0.0016349803 1.394528e-01 5.243892e-01 5 57237113 57237172 60 + 1.428 1.324 -0.359
ENSG00000062194 E027 2.7992602 0.0080455135 3.297605e-03 1.033932e-01 5 57237173 57237489 317 + 0.279 0.755 2.383
ENSG00000062194 E028 35.0260874 0.0019590821 3.886959e-14 4.600744e-10 5 57245468 57246299 832 + 1.257 1.742 1.668
ENSG00000062194 E029 106.8115487 0.0005658888 5.746324e-01 8.642773e-01 5 57246300 57246484 185 + 2.036 2.055 0.065
ENSG00000062194 E030 103.8149023 0.0003667992 3.353326e-01 7.284423e-01 5 57247075 57247215 141 + 2.015 2.049 0.112
ENSG00000062194 E031 3.5693243 0.0216051025 1.007002e-02 1.740613e-01 5 57248862 57249408 547 + 0.399 0.824 1.916
ENSG00000062194 E032 55.9431593 0.0006056420 7.091960e-01 9.183920e-01 5 57249409 57249453 45 + 1.751 1.770 0.065
ENSG00000062194 E033 98.8680426 0.0003086349 1.707824e-01 5.680372e-01 5 57249454 57249576 123 + 1.983 2.032 0.162
ENSG00000062194 E034 134.3700036 0.0004559660 6.053176e-02 3.728152e-01 5 57250954 57251141 188 + 2.110 2.168 0.195
ENSG00000062194 E035 110.2528276 0.0014873009 2.803574e-02 2.714604e-01 5 57261180 57261282 103 + 2.010 2.089 0.264
ENSG00000062194 E036 231.9534138 0.0030440149 5.121519e-02 3.473933e-01 5 57262594 57264679 2086 + 2.338 2.401 0.208