ENSG00000057252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367619 ENSG00000057252 HEK293_DMSO_6hA HEK293_OSMI2_6hA SOAT1 protein_coding protein_coding 14.69531 4.602395 5.428328 1.443732 1.017966 0.2376469 7.4935509 3.89013762 3.897164 1.01147038 0.8689748 0.002596613 0.64259167 0.872766667 0.71323333 -0.1595333 0.68356507 0.04389245 FALSE TRUE
ENST00000426956 ENSG00000057252 HEK293_DMSO_6hA HEK293_OSMI2_6hA SOAT1 protein_coding protein_coding 14.69531 4.602395 5.428328 1.443732 1.017966 0.2376469 6.1646366 0.66477881 1.137797 0.44376618 0.6331557 0.766381186 0.28879167 0.117433333 0.21053333 0.0931000 0.88504478 0.04389245 FALSE FALSE
ENST00000540564 ENSG00000057252 HEK293_DMSO_6hA HEK293_OSMI2_6hA SOAT1 protein_coding protein_coding 14.69531 4.602395 5.428328 1.443732 1.017966 0.2376469 0.8978242 0.01980046 0.393367 0.01980046 0.0350022 3.758686307 0.05502917 0.006133333 0.07623333 0.0701000 0.04389245 0.04389245 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000057252 E001 1.000246 0.0187479086 1.146727e-01   1 179293714 179293780 67 + 0.396 0.127 -2.133
ENSG00000057252 E002 1.850237 0.0098314413 2.570562e-02 0.260976146 1 179293781 179293796 16 + 0.598 0.225 -2.131
ENSG00000057252 E003 29.811172 0.0009814259 3.146950e-02 0.285210863 1 179293797 179293936 140 + 1.549 1.433 -0.399
ENSG00000057252 E004 0.000000       1 179294320 179294401 82 +      
ENSG00000057252 E005 43.376447 0.0010562729 6.136280e-01 0.881657460 1 179302677 179302802 126 + 1.662 1.653 -0.031
ENSG00000057252 E006 32.979675 0.0042839721 7.827649e-01 0.943012780 1 179323437 179323495 59 + 1.527 1.558 0.108
ENSG00000057252 E007 50.413528 0.0016174252 2.581828e-01 0.663868393 1 179335506 179335657 152 + 1.741 1.702 -0.130
ENSG00000057252 E008 35.018953 0.0088174574 2.043927e-01 0.608235603 1 179337837 179337896 60 + 1.595 1.524 -0.243
ENSG00000057252 E009 48.363693 0.0059707758 9.050398e-02 0.439526561 1 179339438 179339545 108 + 1.738 1.655 -0.279
ENSG00000057252 E010 83.867920 0.0004014958 3.793498e-01 0.759657779 1 179341028 179341310 283 + 1.941 1.928 -0.044
ENSG00000057252 E011 49.232792 0.0005778479 5.030009e-01 0.831306339 1 179342114 179342192 79 + 1.713 1.700 -0.046
ENSG00000057252 E012 50.669426 0.0007488571 8.616509e-01 0.966223919 1 179342862 179342943 82 + 1.711 1.723 0.039
ENSG00000057252 E013 37.279217 0.0028842586 5.078623e-01 0.833785945 1 179343590 179343635 46 + 1.594 1.575 -0.066
ENSG00000057252 E014 61.716894 0.0009192724 1.449200e-01 0.532123361 1 179344947 179345076 130 + 1.825 1.780 -0.151
ENSG00000057252 E015 61.621610 0.0013683472 6.646389e-01 0.902142697 1 179347600 179347697 98 + 1.799 1.799 -0.002
ENSG00000057252 E016 66.502848 0.0059732970 4.154884e-01 0.783798402 1 179348844 179348942 99 + 1.841 1.816 -0.084
ENSG00000057252 E017 65.613663 0.0029966990 5.943112e-01 0.873235131 1 179350296 179350431 136 + 1.826 1.823 -0.011
ENSG00000057252 E018 63.992985 0.0004664576 4.615415e-02 0.333238571 1 179351317 179351462 146 + 1.851 1.785 -0.222
ENSG00000057252 E019 506.582270 0.0025260567 3.475409e-05 0.006952193 1 179353585 179358680 5096 + 2.657 2.754 0.321