ENSG00000040487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375153 ENSG00000040487 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLC66A1 protein_coding protein_coding 24.29116 22.42536 32.79758 2.566536 4.898662 0.5482545 3.648664 2.9789890 4.462645 0.7735136 0.7156601 0.5814705 0.15036667 0.1284000 0.13630000 0.00790000 0.9065203704 0.0002323073 FALSE TRUE
ENST00000375155 ENSG00000040487 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLC66A1 protein_coding protein_coding 24.29116 22.42536 32.79758 2.566536 4.898662 0.5482545 11.702392 9.6424594 15.744520 0.4445092 2.6271587 0.7067973 0.48233750 0.4383000 0.47696667 0.03866667 0.7483774383 0.0002323073 FALSE TRUE
ENST00000432465 ENSG00000040487 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLC66A1 protein_coding protein_coding 24.29116 22.42536 32.79758 2.566536 4.898662 0.5482545 3.272468 4.2984639 3.150431 0.6079861 0.5072545 -0.4470522 0.14148750 0.1903333 0.09586667 -0.09446667 0.0002323073 0.0002323073 FALSE TRUE
MSTRG.469.1 ENSG00000040487 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLC66A1 protein_coding   24.29116 22.42536 32.79758 2.566536 4.898662 0.5482545 1.381840 0.9317091 2.439714 0.4705360 0.8067567 1.3792597 0.05029583 0.0446000 0.07220000 0.02760000 0.7481864508 0.0002323073 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000040487 E001 0.4062432 0.0244411696 0.1642260818   1 19312243 19312243 1 + 0.251 0.000 -9.887
ENSG00000040487 E002 1.7172896 0.0105853601 0.0802651755 0.41815646 1 19312244 19312267 24 + 0.557 0.247 -1.765
ENSG00000040487 E003 3.4417309 0.0064358506 0.5820814016 0.86767746 1 19312268 19312285 18 + 0.692 0.610 -0.350
ENSG00000040487 E004 24.4558491 0.0010674512 0.0344705921 0.29564236 1 19312286 19312325 40 + 1.462 1.314 -0.515
ENSG00000040487 E005 25.8695801 0.0010630348 0.0205204213 0.23837650 1 19312326 19312329 4 + 1.489 1.329 -0.550
ENSG00000040487 E006 34.9499931 0.0007705411 0.0011120350 0.05751380 1 19312330 19312340 11 + 1.629 1.433 -0.671
ENSG00000040487 E007 69.0755225 0.0004407906 0.0003182618 0.02758308 1 19312341 19312358 18 + 1.902 1.748 -0.520
ENSG00000040487 E008 49.3938689 0.0053382369 0.6717457497 0.90483260 1 19312359 19312728 370 + 1.682 1.718 0.123
ENSG00000040487 E009 166.2805364 0.0002117102 0.4526124929 0.80489755 1 19312729 19312889 161 + 2.228 2.209 -0.061
ENSG00000040487 E010 239.4913119 0.0002194884 0.2198827526 0.62448759 1 19317600 19317841 242 + 2.388 2.363 -0.084
ENSG00000040487 E011 187.0591177 0.0001795823 0.3446805561 0.73539515 1 19324633 19324753 121 + 2.280 2.258 -0.074
ENSG00000040487 E012 85.7713751 0.0004130686 0.4720663145 0.81502867 1 19324754 19324762 9 + 1.944 1.918 -0.086
ENSG00000040487 E013 85.2572666 0.0014174776 0.2863188543 0.68860555 1 19325495 19325525 31 + 1.944 1.904 -0.135
ENSG00000040487 E014 123.4782027 0.0003369607 0.4937678790 0.82626960 1 19325526 19325582 57 + 2.098 2.078 -0.066
ENSG00000040487 E015 179.0679421 0.0004865234 0.4610321476 0.80906387 1 19326245 19326387 143 + 2.261 2.243 -0.060
ENSG00000040487 E016 180.4084791 0.0011275728 0.6602253250 0.90068355 1 19326531 19326623 93 + 2.249 2.265 0.053
ENSG00000040487 E017 216.4561884 0.0001574996 0.1190130206 0.49168511 1 19327227 19327412 186 + 2.317 2.355 0.128
ENSG00000040487 E018 125.4579633 0.0029816265 0.0001159417 0.01465287 1 19327571 19328053 483 + 2.018 2.178 0.535
ENSG00000040487 E019 40.5838379 0.0007748956 0.0030257828 0.09901651 1 19328054 19328081 28 + 1.537 1.700 0.554
ENSG00000040487 E020 311.8994138 0.0013214836 0.2861137895 0.68847208 1 19328572 19328800 229 + 2.480 2.510 0.101
ENSG00000040487 E021 404.4809383 0.0001331073 0.3008414646 0.70054541 1 19328801 19329300 500 + 2.595 2.614 0.065
ENSG00000040487 E022 9.4613130 0.0105077295 0.4008864710 0.77391011 1 19331342 19331453 112 + 0.971 1.071 0.368