ENSG00000038219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000040738 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding protein_coding 9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 3.6887897 1.7236026 2.6219131 0.5660245 0.4425779 0.6023386 0.37377500 0.2762000 0.30563333 0.029433333 8.051617e-01 4.916764e-11 FALSE TRUE
ENST00000507943 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding protein_coding 9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 0.6673579 0.6651469 1.7891019 0.1657682 0.7270089 1.4140036 0.09937500 0.1138667 0.18666667 0.072800000 6.873713e-01 4.916764e-11 FALSE TRUE
ENST00000509897 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding retained_intron 9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 0.5699547 0.8405023 0.0000000 0.2232292 0.0000000 -6.4102432 0.05667083 0.1392667 0.00000000 -0.139266667 4.916764e-11 4.916764e-11   FALSE
MSTRG.24637.2 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding   9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 1.2242824 0.2403530 0.5253365 0.1380053 0.1975690 1.0964819 0.10561667 0.0360000 0.05753333 0.021533333 7.499573e-01 4.916764e-11 FALSE TRUE
MSTRG.24637.4 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding   9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 1.3177407 1.2643389 1.8282035 0.8100987 1.0277320 0.5285474 0.13931667 0.1761333 0.18320000 0.007066667 9.500251e-01 4.916764e-11 FALSE TRUE
MSTRG.24637.8 ENSG00000038219 HEK293_DMSO_6hA HEK293_OSMI2_6hA BOD1L1 protein_coding   9.452199 6.216444 8.910958 1.982379 2.008009 0.5187901 1.2447069 0.7434205 1.6684853 0.3852936 0.6043980 1.1556328 0.13960000 0.1265667 0.20373333 0.077166667 7.455315e-01 4.916764e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000038219 E001 115.4933085 0.0140841986 0.616541002 0.88271566 4 13568738 13569505 768 - 2.054 2.074 0.066
ENSG00000038219 E002 46.2073945 0.0171409580 0.359343297 0.74643784 4 13569506 13569785 280 - 1.701 1.623 -0.262
ENSG00000038219 E003 20.7622872 0.0013679057 0.287782538 0.68974322 4 13569786 13569838 53 - 1.369 1.291 -0.272
ENSG00000038219 E004 14.1779209 0.0019883368 0.134273316 0.51662472 4 13569839 13569855 17 - 1.234 1.100 -0.477
ENSG00000038219 E005 11.7988827 0.0041386695 0.069057009 0.39365390 4 13569856 13569856 1 - 1.177 0.995 -0.661
ENSG00000038219 E006 20.7438174 0.0015017453 0.045908130 0.33257805 4 13569857 13569889 33 - 1.397 1.245 -0.527
ENSG00000038219 E007 73.0166791 0.0010937091 0.174862921 0.57265533 4 13569890 13570128 239 - 1.894 1.838 -0.189
ENSG00000038219 E008 14.7480700 0.0019813694 0.174091809 0.57176421 4 13572702 13572842 141 - 1.246 1.126 -0.429
ENSG00000038219 E009 70.1228784 0.0034745813 0.495892683 0.82731040 4 13576838 13576991 154 - 1.872 1.837 -0.117
ENSG00000038219 E010 53.8131120 0.0012840672 0.628868708 0.88744575 4 13577403 13577487 85 - 1.736 1.761 0.086
ENSG00000038219 E011 0.1717682 0.0470601576 0.335923036   4 13577581 13577581 1 - 0.000 0.142 8.932
ENSG00000038219 E012 37.7246260 0.0010743519 0.219673386 0.62427879 4 13577582 13577631 50 - 1.557 1.630 0.248
ENSG00000038219 E013 1.6662613 0.0304526882 0.015775972 0.21356267 4 13577632 13578201 570 - 0.182 0.611 2.562
ENSG00000038219 E014 32.8813533 0.0009869445 0.373264954 0.75544998 4 13579928 13579969 42 - 1.511 1.567 0.191
ENSG00000038219 E015 22.2572641 0.0105037000 0.784513896 0.94358161 4 13579970 13579973 4 - 1.371 1.388 0.061
ENSG00000038219 E016 2.0731940 0.0096552127 0.001298747 0.06280686 4 13579974 13580066 93 - 0.182 0.720 3.029
ENSG00000038219 E017 28.2953702 0.0023923063 0.504774273 0.83202002 4 13581020 13581051 32 - 1.496 1.453 -0.146
ENSG00000038219 E018 16.3899052 0.0021791108 0.714515879 0.92023963 4 13581052 13581054 3 - 1.253 1.226 -0.096
ENSG00000038219 E019 1.9264114 0.1410978641 0.602133775 0.87652106 4 13581128 13581131 4 - 0.411 0.520 0.552
ENSG00000038219 E020 35.9386490 0.0145512411 0.376634406 0.75771649 4 13581132 13581207 76 - 1.600 1.535 -0.222
ENSG00000038219 E021 0.0000000       4 13582230 13582236 7 -      
ENSG00000038219 E022 37.2926780 0.0046745837 0.180883749 0.58049898 4 13582237 13582310 74 - 1.626 1.542 -0.285
ENSG00000038219 E023 40.1660055 0.0006662746 0.564461666 0.85967437 4 13582652 13582736 85 - 1.632 1.602 -0.102
ENSG00000038219 E024 40.0828940 0.0007765893 0.990411236 0.99762334 4 13586396 13586475 80 - 1.616 1.618 0.009
ENSG00000038219 E025 36.9755867 0.0008961984 0.692927870 0.91275861 4 13587699 13587771 73 - 1.573 1.598 0.085
ENSG00000038219 E026 35.9221008 0.0009073673 0.516899345 0.83861076 4 13588722 13588792 71 - 1.554 1.593 0.134
ENSG00000038219 E027 30.3927515 0.0010756751 0.777872554 0.94169221 4 13590386 13590446 61 - 1.504 1.488 -0.057
ENSG00000038219 E028 28.0028435 0.0033260639 0.475344648 0.81689478 4 13591923 13591966 44 - 1.439 1.487 0.165
ENSG00000038219 E029 7.0519204 0.0366241589 0.016286121 0.21633638 4 13591967 13593520 1554 - 0.716 1.058 1.310
ENSG00000038219 E030 35.4515003 0.0101497431 0.918133064 0.98033087 4 13595860 13595944 85 - 1.561 1.562 0.004
ENSG00000038219 E031 27.4721932 0.0021715561 0.970135872 0.99305214 4 13597104 13597168 65 - 1.455 1.453 -0.007
ENSG00000038219 E032 122.9011105 0.0006854249 0.877781938 0.97069993 4 13598946 13599966 1021 - 2.102 2.099 -0.012
ENSG00000038219 E033 154.8475004 0.0002305319 0.107326129 0.47050969 4 13599967 13601540 1574 - 2.177 2.223 0.152
ENSG00000038219 E034 30.3506109 0.0139460252 0.408621828 0.77946719 4 13601541 13601831 291 - 1.462 1.541 0.272
ENSG00000038219 E035 18.7204146 0.0132919576 0.573023728 0.86351835 4 13601832 13601933 102 - 1.319 1.272 -0.167
ENSG00000038219 E036 166.8685648 0.0167115236 0.520206205 0.84017588 4 13601934 13605084 3151 - 2.233 2.209 -0.081
ENSG00000038219 E037 4.6363300 0.0325155131 0.543977142 0.85168303 4 13607117 13607121 5 - 0.711 0.806 0.381
ENSG00000038219 E038 8.4045037 0.0059349888 0.134130233 0.51638099 4 13607122 13607189 68 - 0.903 1.072 0.625
ENSG00000038219 E039 13.2933320 0.0219095746 0.239213014 0.64444967 4 13608530 13608668 139 - 1.091 1.242 0.538
ENSG00000038219 E040 11.7794649 0.0362319549 0.870939279 0.96839798 4 13609295 13609406 112 - 1.102 1.121 0.066
ENSG00000038219 E041 13.3055967 0.0060929247 0.093320437 0.44465611 4 13610934 13611100 167 - 1.231 1.072 -0.570
ENSG00000038219 E042 0.0000000       4 13613506 13613511 6 -      
ENSG00000038219 E043 9.0579925 0.0031600182 0.147316849 0.53539915 4 13613512 13613661 150 - 1.076 0.921 -0.572
ENSG00000038219 E044 21.2122633 0.0481677906 0.693499036 0.91302882 4 13614196 13614810 615 - 1.313 1.384 0.247
ENSG00000038219 E045 9.9979929 0.0321966512 0.770541228 0.93961117 4 13615312 13615502 191 - 1.036 1.083 0.170
ENSG00000038219 E046 5.5424783 0.0051338708 0.285142308 0.68765926 4 13619943 13620067 125 - 0.889 0.751 -0.541
ENSG00000038219 E047 32.6296747 0.0683740230 0.149876155 0.53935822 4 13623390 13626312 2923 - 1.436 1.614 0.611
ENSG00000038219 E048 8.5579788 0.0318832879 0.096723161 0.45133753 4 13627345 13627725 381 - 0.885 1.087 0.751