ENSG00000035681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000038176 ENSG00000035681 HEK293_DMSO_6hA HEK293_OSMI2_6hA NSMAF protein_coding protein_coding 9.299532 5.766879 4.176828 1.493196 0.185378 -0.4644328 1.5434473 0.8777522 0.7297560 0.2366733 0.11106609 -0.2631077 0.19597917 0.1516667 0.17470000 0.02303333 0.84010000 0.03735688 FALSE TRUE
ENST00000427130 ENSG00000035681 HEK293_DMSO_6hA HEK293_OSMI2_6hA NSMAF protein_coding protein_coding 9.299532 5.766879 4.176828 1.493196 0.185378 -0.4644328 4.9890752 1.9393773 2.1028605 0.5509240 0.46350175 0.1161842 0.52185000 0.3330667 0.50240000 0.16933333 0.55949388 0.03735688 FALSE TRUE
ENST00000517612 ENSG00000035681 HEK293_DMSO_6hA HEK293_OSMI2_6hA NSMAF protein_coding retained_intron 9.299532 5.766879 4.176828 1.493196 0.185378 -0.4644328 0.1573275 0.4755934 0.0000000 0.2424190 0.00000000 -5.6016768 0.02034167 0.1012333 0.00000000 -0.10123333 0.03735688 0.03735688 FALSE TRUE
ENST00000519227 ENSG00000035681 HEK293_DMSO_6hA HEK293_OSMI2_6hA NSMAF protein_coding retained_intron 9.299532 5.766879 4.176828 1.493196 0.185378 -0.4644328 0.6302857 0.3966714 0.1624802 0.1048103 0.03138896 -1.2374330 0.05377917 0.0723000 0.03843333 -0.03386667 0.71084874 0.03735688   FALSE
ENST00000523106 ENSG00000035681 HEK293_DMSO_6hA HEK293_OSMI2_6hA NSMAF protein_coding retained_intron 9.299532 5.766879 4.176828 1.493196 0.185378 -0.4644328 0.9923098 1.1143938 0.7952768 0.4941850 0.41498145 -0.4815908 0.10277083 0.1777333 0.19190000 0.01416667 0.95980066 0.03735688 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000035681 E001 0.4633820 0.3447215945 0.2374325018   8 58576986 58577093 108 - 0.000 0.272 12.827
ENSG00000035681 E002 0.3485388 0.0415848158 0.9197518212   8 58583508 58583531 24 - 0.127 0.113 -0.194
ENSG00000035681 E003 10.2168222 0.0023532731 0.2393227629 0.64454055 8 58583532 58583588 57 - 0.976 1.099 0.451
ENSG00000035681 E004 30.9603383 0.0009193657 0.2710881147 0.67529040 8 58583589 58583769 181 - 1.464 1.534 0.242
ENSG00000035681 E005 27.5297594 0.0052330808 0.3294551455 0.72403085 8 58583770 58583808 39 - 1.415 1.490 0.257
ENSG00000035681 E006 52.8654175 0.0006428710 0.0047781592 0.12411139 8 58583809 58584033 225 - 1.653 1.791 0.467
ENSG00000035681 E007 43.1060535 0.0011739657 0.5093697184 0.83439237 8 58584034 58584200 167 - 1.626 1.663 0.128
ENSG00000035681 E008 37.5829882 0.0008779035 0.5891411451 0.87097340 8 58585652 58585761 110 - 1.605 1.577 -0.093
ENSG00000035681 E009 1.0927794 0.2858072915 0.9310609981   8 58585762 58585897 136 - 0.307 0.334 0.173
ENSG00000035681 E010 35.0902113 0.0104161009 0.7867978082 0.94420758 8 58585898 58586000 103 - 1.547 1.567 0.067
ENSG00000035681 E011 0.3262289 0.0274424043 0.2446350120   8 58586349 58586358 10 - 0.000 0.202 12.322
ENSG00000035681 E012 0.3262289 0.0274424043 0.2446350120   8 58586359 58586457 99 - 0.000 0.202 12.322
ENSG00000035681 E013 37.3804785 0.0021585177 0.1396512160 0.52458320 8 58586458 58586608 151 - 1.541 1.628 0.299
ENSG00000035681 E014 24.9903919 0.0035075730 0.0906463547 0.43978966 8 58587618 58587648 31 - 1.348 1.469 0.420
ENSG00000035681 E015 24.2488315 0.0013066771 0.1196714652 0.49302068 8 58587649 58587701 53 - 1.342 1.452 0.380
ENSG00000035681 E016 27.1253012 0.0010800996 0.0265417100 0.26474586 8 58589452 58589521 70 - 1.362 1.511 0.515
ENSG00000035681 E017 26.8156870 0.0011781005 0.1897119834 0.59115660 8 58589522 58589558 37 - 1.393 1.482 0.309
ENSG00000035681 E018 18.1867814 0.0015124249 0.3088087792 0.70713269 8 58589559 58589575 17 - 1.237 1.320 0.291
ENSG00000035681 E019 1.1135131 0.0659792153 0.3623172816   8 58589576 58589751 176 - 0.224 0.395 1.131
ENSG00000035681 E020 3.2996382 0.0062909183 0.2293463742 0.63446619 8 58589752 58590000 249 - 0.527 0.712 0.810
ENSG00000035681 E021 1.8211365 0.0100763163 0.5070365993 0.83324958 8 58590001 58590006 6 - 0.372 0.488 0.615
ENSG00000035681 E022 23.9764146 0.0015672993 0.3096969405 0.70790496 8 58590007 58590046 40 - 1.349 1.423 0.257
ENSG00000035681 E023 19.0425418 0.0035922567 0.5004437378 0.82985324 8 58590047 58590074 28 - 1.263 1.319 0.199
ENSG00000035681 E024 0.0000000       8 58590866 58590866 1 -      
ENSG00000035681 E025 27.1219623 0.0097527362 0.9171515682 0.98019030 8 58590867 58590934 68 - 1.446 1.437 -0.031
ENSG00000035681 E026 0.3513410 0.0304248884 0.2421797129   8 58590935 58591009 75 - 0.000 0.202 12.324
ENSG00000035681 E027 27.7363676 0.0036478177 0.2305414526 0.63547405 8 58594232 58594290 59 - 1.494 1.413 -0.279
ENSG00000035681 E028 0.8571427 0.0190289937 0.0250859738   8 58594291 58594737 447 - 0.000 0.395 13.646
ENSG00000035681 E029 0.5058017 0.0219022496 0.1094154842   8 58594738 58594878 141 - 0.000 0.276 12.908
ENSG00000035681 E030 32.1792485 0.0012820162 0.7248675136 0.92393373 8 58595560 58595659 100 - 1.525 1.507 -0.063
ENSG00000035681 E031 0.0000000       8 58595800 58595902 103 -      
ENSG00000035681 E032 18.9536059 0.0104175316 0.7197534973 0.92211183 8 58597387 58597402 16 - 1.309 1.281 -0.100
ENSG00000035681 E033 27.8139034 0.0177637983 0.4665840558 0.81216400 8 58597403 58597472 70 - 1.485 1.427 -0.201
ENSG00000035681 E034 31.6353969 0.0295618676 0.7965778442 0.94712204 8 58597473 58597550 78 - 1.514 1.503 -0.038
ENSG00000035681 E035 25.2928083 0.0187560596 0.7430007246 0.93033351 8 58597860 58597902 43 - 1.389 1.430 0.145
ENSG00000035681 E036 35.4674301 0.0008780128 0.9636588106 0.99169035 8 58599232 58599363 132 - 1.563 1.563 0.002
ENSG00000035681 E037 2.4395422 0.3786007002 0.6383983406 0.89157200 8 58599364 58599376 13 - 0.441 0.592 0.721
ENSG00000035681 E038 3.2997256 0.1432642755 0.4999573245 0.82955388 8 58599377 58599480 104 - 0.528 0.706 0.785
ENSG00000035681 E039 27.7324085 0.0011909990 0.2678001347 0.67225493 8 58599750 58599870 121 - 1.502 1.433 -0.237
ENSG00000035681 E040 18.2858551 0.0018967959 0.1525508904 0.54280866 8 58599970 58600021 52 - 1.348 1.238 -0.385
ENSG00000035681 E041 1.7832173 0.0107267102 0.1999107925 0.60333852 8 58600022 58600112 91 - 0.305 0.528 1.223
ENSG00000035681 E042 2.1317561 0.0130501296 0.2618488778 0.66709569 8 58600113 58600178 66 - 0.372 0.564 0.976
ENSG00000035681 E043 1.3824521 0.1938754485 0.2908707311   8 58601168 58601284 117 - 0.229 0.446 1.369
ENSG00000035681 E044 21.9665316 0.0019970972 0.9788173744 0.99484557 8 58601285 58601348 64 - 1.362 1.366 0.016
ENSG00000035681 E045 23.2767077 0.0014956191 0.9899119748 0.99749298 8 58601445 58601535 91 - 1.381 1.383 0.006
ENSG00000035681 E046 19.0759680 0.0014321826 0.1693487580 0.56639522 8 58602058 58602137 80 - 1.362 1.260 -0.355
ENSG00000035681 E047 23.1497303 0.0018497387 0.1716901092 0.56919131 8 58603210 58603386 177 - 1.442 1.349 -0.322
ENSG00000035681 E048 20.5794538 0.0132319275 0.2621450990 0.66733865 8 58605927 58606035 109 - 1.381 1.298 -0.289
ENSG00000035681 E049 19.0112455 0.0018513399 0.0037918096 0.11027325 8 58607769 58607840 72 - 1.410 1.191 -0.767
ENSG00000035681 E050 25.8636775 0.0011396002 0.0007301333 0.04543394 8 58609604 58609733 130 - 1.546 1.326 -0.760
ENSG00000035681 E051 16.5967380 0.0020266729 0.0161551904 0.21585716 8 58623220 58623272 53 - 1.348 1.157 -0.676
ENSG00000035681 E052 14.4537578 0.0039721003 0.0657016849 0.38615878 8 58623377 58623424 48 - 1.277 1.119 -0.561
ENSG00000035681 E053 13.9582637 0.0022732249 0.0130056979 0.19622867 8 58623709 58623746 38 - 1.292 1.078 -0.761
ENSG00000035681 E054 7.9904272 0.0047191823 0.3813685393 0.76105278 8 58623747 58623750 4 - 1.019 0.925 -0.350
ENSG00000035681 E055 10.1388305 0.0026471803 0.0353964883 0.29842219 8 58623751 58623780 30 - 1.162 0.955 -0.756
ENSG00000035681 E056 0.1544607 0.0314880146 0.5559746891   8 58631365 58631427 63 - 0.000 0.113 11.321
ENSG00000035681 E057 0.0000000       8 58631428 58631495 68 -      
ENSG00000035681 E058 11.5663534 0.0022616077 0.4221252943 0.78742317 8 58631496 58631546 51 - 1.142 1.067 -0.268
ENSG00000035681 E059 12.6359282 0.0021202959 0.5458762913 0.85231170 8 58635189 58635225 37 - 1.097 1.157 0.213
ENSG00000035681 E060 14.5956213 0.0018938807 0.4450385698 0.80066534 8 58635305 58635372 68 - 1.152 1.223 0.251
ENSG00000035681 E061 13.7939504 0.0091363205 0.6834645604 0.90956943 8 58635468 58635546 79 - 1.150 1.191 0.145
ENSG00000035681 E062 0.1544607 0.0314880146 0.5559746891   8 58637234 58637389 156 - 0.000 0.113 11.321
ENSG00000035681 E063 0.3794938 0.0363833663 0.5012342950   8 58639968 58640102 135 - 0.223 0.113 -1.183
ENSG00000035681 E064 11.8210038 0.0031301058 0.2210382570 0.62567095 8 58642984 58643073 90 - 1.181 1.067 -0.409
ENSG00000035681 E065 0.0000000       8 58651083 58651173 91 -      
ENSG00000035681 E066 2.2620848 0.0088372567 0.0402451600 0.31490841 8 58659195 58659572 378 - 0.674 0.340 -1.647
ENSG00000035681 E067 6.4580732 0.0445666567 0.9524581860 0.98892692 8 58659573 58661218 1646 - 0.882 0.891 0.034