ENSG00000013588

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000014914 ENSG00000013588 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPRC5A protein_coding protein_coding 0.5994555 0.5492861 1.202707 0.1046834 0.2776409 1.116573 0.32076700 0.47692262 0.4421936 0.05979223 0.02014644 -0.1067519 0.63777917 0.89063333 0.4019333 -0.48870000 0.0489671 0.0489671 FALSE TRUE
ENST00000534831 ENSG00000013588 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPRC5A protein_coding protein_coding 0.5994555 0.5492861 1.202707 0.1046834 0.2776409 1.116573 0.09455426 0.00000000 0.4022478 0.00000000 0.21652097 5.3654399 0.12768333 0.00000000 0.3102000 0.31020000 0.3287605 0.0489671 FALSE FALSE
ENST00000542056 ENSG00000013588 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPRC5A protein_coding processed_transcript 0.5994555 0.5492861 1.202707 0.1046834 0.2776409 1.116573 0.12933300 0.06184184 0.1905639 0.06184184 0.19056389 1.4811657 0.13022083 0.08263333 0.1084000 0.02576667 0.9615809 0.0489671   FALSE
ENST00000648791 ENSG00000013588 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPRC5A protein_coding protein_coding 0.5994555 0.5492861 1.202707 0.1046834 0.2776409 1.116573 0.03488413 0.00000000 0.1534144 0.00000000 0.15341441 4.0304633 0.05623333 0.00000000 0.1638333 0.16383333 0.8579570 0.0489671 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000013588 E001 0.9690572 0.121656820 0.480893698   12 12891559 12891561 3 + 0.353 0.217 -0.952
ENSG00000013588 E002 1.3485510 0.104183000 0.419585552   12 12891562 12891578 17 + 0.454 0.294 -0.930
ENSG00000013588 E003 2.9063776 0.028536090 0.039942848 0.31386414 12 12891579 12891664 86 + 0.748 0.419 -1.504
ENSG00000013588 E004 0.0000000       12 12891974 12892042 69 +      
ENSG00000013588 E005 1.6126387 0.046351847 0.157523363   12 12908243 12908243 1 + 0.538 0.295 -1.331
ENSG00000013588 E006 22.0511570 0.004084147 0.002927352 0.09715373 12 12908244 12909068 825 + 1.447 1.253 -0.675
ENSG00000013588 E007 3.3965111 0.375347727 0.389474049 0.76661280 12 12909069 12909070 2 + 0.473 0.747 1.215
ENSG00000013588 E008 4.8523379 0.089938881 0.172599687 0.57013747 12 12909071 12909171 101 + 0.582 0.878 1.215
ENSG00000013588 E009 0.0000000       12 12909172 12909876 705 +      
ENSG00000013588 E010 5.0650050 0.005177468 0.349946360 0.73936659 12 12912084 12912142 59 + 0.701 0.835 0.537
ENSG00000013588 E011 0.1125166 0.033222802 0.502226896   12 12912143 12912300 158 + 0.117 0.000 -8.142
ENSG00000013588 E012 0.0000000       12 12912301 12912446 146 +      
ENSG00000013588 E013 6.0710973 0.004697446 0.485673178 0.82231621 12 12912447 12912509 63 + 0.796 0.893 0.376
ENSG00000013588 E014 16.6386638 0.049559149 0.757291876 0.93502082 12 12912510 12913133 624 + 1.234 1.262 0.100
ENSG00000013588 E015 10.9907104 0.003002906 0.207504539 0.61142590 12 12913134 12913411 278 + 1.127 1.018 -0.396
ENSG00000013588 E016 25.4881012 0.007076567 0.421659816 0.78710434 12 12913412 12915828 2417 + 1.380 1.447 0.233
ENSG00000013588 E017 1.9558723 0.012100931 0.262096753 0.66730854 12 12915829 12915918 90 + 0.542 0.361 -0.937
ENSG00000013588 E018 31.8794990 0.011229072 0.058381682 0.36748998 12 12915919 12917937 2019 + 1.434 1.571 0.468