ENSG00000012211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376310 ENSG00000012211 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRICKLE3 protein_coding retained_intron 8.871496 9.457185 13.81095 0.8159793 2.012398 0.5458495 0.9820108 1.971872 1.286625 0.2349425 0.3760382 -0.6121029 0.12161250 0.2091000 0.10586667 -0.10323333 3.487590e-01 6.036433e-06 FALSE TRUE
ENST00000453382 ENSG00000012211 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRICKLE3 protein_coding protein_coding 8.871496 9.457185 13.81095 0.8159793 2.012398 0.5458495 1.4694931 2.529855 2.995001 0.6694707 0.3013698 0.2426195 0.18180000 0.2612667 0.22266667 -0.03860000 7.865828e-01 6.036433e-06 FALSE TRUE
ENST00000599218 ENSG00000012211 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRICKLE3 protein_coding protein_coding 8.871496 9.457185 13.81095 0.8159793 2.012398 0.5458495 4.6251039 3.242039 6.821174 0.4197051 1.6758462 1.0707890 0.49182500 0.3447667 0.48003333 0.13526667 4.858421e-01 6.036433e-06 FALSE TRUE
ENST00000614014 ENSG00000012211 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRICKLE3 protein_coding retained_intron 8.871496 9.457185 13.81095 0.8159793 2.012398 0.5458495 0.8763600 1.266258 1.117862 0.1300851 0.2820431 -0.1783292 0.10149167 0.1384000 0.08236667 -0.05603333 5.790619e-01 6.036433e-06 TRUE FALSE
MSTRG.34237.3 ENSG00000012211 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRICKLE3 protein_coding   8.871496 9.457185 13.81095 0.8159793 2.012398 0.5458495 0.5404031 0.000000 1.021419 0.0000000 0.4506644 6.6884869 0.05388333 0.0000000 0.06856667 0.06856667 6.036433e-06 6.036433e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000012211 E001 72.033183 0.0050526373 0.383986121 0.7629187 X 49174802 49175263 462 - 1.832 1.887 0.186
ENSG00000012211 E002 68.301690 0.0044885945 0.482334344 0.8205657 X 49175264 49175620 357 - 1.842 1.816 -0.087
ENSG00000012211 E003 174.720927 0.0015712137 0.661157153 0.9008956 X 49175621 49176265 645 - 2.227 2.254 0.089
ENSG00000012211 E004 105.208731 0.0003106447 0.016887042 0.2199672 X 49176903 49177136 234 - 2.049 1.977 -0.239
ENSG00000012211 E005 63.465227 0.0012627822 0.141537229 0.5273051 X 49177137 49177202 66 - 1.823 1.768 -0.188
ENSG00000012211 E006 1.079374 0.0142416190 0.342918717   X 49177989 49177992 4 - 0.244 0.415 1.085
ENSG00000012211 E007 112.094433 0.0003697300 0.709883759 0.9186649 X 49177993 49178179 187 - 2.039 2.060 0.073
ENSG00000012211 E008 10.772455 0.0218475971 0.145220545 0.5326328 X 49178180 49178271 92 - 0.987 1.165 0.644
ENSG00000012211 E009 118.913839 0.0009533348 0.583240648 0.8681911 X 49178272 49178475 204 - 2.064 2.091 0.093
ENSG00000012211 E010 100.436928 0.0004796065 0.561575889 0.8586501 X 49179251 49179388 138 - 2.008 1.997 -0.038
ENSG00000012211 E011 30.501529 0.0874851910 0.004464009 0.1197559 X 49179405 49179692 288 - 1.259 1.691 1.485
ENSG00000012211 E012 86.577565 0.0004540390 0.629317466 0.8876780 X 49179693 49179805 113 - 1.925 1.953 0.093
ENSG00000012211 E013 38.878121 0.0008538202 0.679799823 0.9081211 X 49179806 49179806 1 - 1.585 1.617 0.109
ENSG00000012211 E014 4.115212 0.1934275285 0.639103018 0.8919293 X 49179807 49179836 30 - 0.655 0.763 0.445
ENSG00000012211 E015 1.833442 0.0097675737 0.026661614 0.2653973 X 49183594 49183656 63 - 0.244 0.623 2.082
ENSG00000012211 E016 4.537720 0.0170736837 0.118796103 0.4914124 X 49183657 49183733 77 - 0.606 0.845 0.983
ENSG00000012211 E017 97.767048 0.0004327084 0.476467256 0.8174425 X 49183734 49183917 184 - 1.999 1.983 -0.054
ENSG00000012211 E018 55.156655 0.0005672025 0.130023885 0.5103420 X 49184625 49184710 86 - 1.769 1.707 -0.211
ENSG00000012211 E019 2.046552 0.2750537270 0.348014214 0.7378593 X 49184711 49184789 79 - 0.370 0.577 1.051
ENSG00000012211 E020 2.999530 0.0087769180 0.483444158 0.8211439 X 49184826 49184963 138 - 0.546 0.662 0.517
ENSG00000012211 E021 43.940172 0.0008492383 0.001086115 0.0567467 X 49186256 49186528 273 - 1.708 1.539 -0.575