ENSG00000011426

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265748 ENSG00000011426 HEK293_DMSO_6hA HEK293_OSMI2_6hA ANLN protein_coding protein_coding 31.15777 6.689777 7.314439 2.083321 1.221173 0.1286051 18.1421027 3.3661931 4.0684797 1.1403559 0.46834907 0.2726340 0.53887917 0.49550000 0.56860000 0.07310000 0.74126348 0.01396726 FALSE TRUE
ENST00000396068 ENSG00000011426 HEK293_DMSO_6hA HEK293_OSMI2_6hA ANLN protein_coding protein_coding 31.15777 6.689777 7.314439 2.083321 1.221173 0.1286051 8.7943758 0.7394471 1.4822532 0.3753809 0.45235018 0.9935938 0.22824583 0.09830000 0.19306667 0.09476667 0.34077251 0.01396726 FALSE TRUE
ENST00000446635 ENSG00000011426 HEK293_DMSO_6hA HEK293_OSMI2_6hA ANLN protein_coding protein_coding 31.15777 6.689777 7.314439 2.083321 1.221173 0.1286051 0.4374760 0.2363033 0.0000000 0.1549196 0.00000000 -4.6223640 0.01349167 0.05013333 0.00000000 -0.05013333 0.34954373 0.01396726 FALSE FALSE
ENST00000491782 ENSG00000011426 HEK293_DMSO_6hA HEK293_OSMI2_6hA ANLN protein_coding retained_intron 31.15777 6.689777 7.314439 2.083321 1.221173 0.1286051 0.4313331 1.1238634 0.2364044 0.1255219 0.05690758 -2.2021466 0.05235417 0.18983333 0.03493333 -0.15490000 0.01396726 0.01396726   FALSE
MSTRG.29734.10 ENSG00000011426 HEK293_DMSO_6hA HEK293_OSMI2_6hA ANLN protein_coding   31.15777 6.689777 7.314439 2.083321 1.221173 0.1286051 0.7117091 0.7306528 0.5093006 0.4817751 0.26288535 -0.5122277 0.07529167 0.09236667 0.05953333 -0.03283333 0.94673826 0.01396726 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000011426 E001 2.9896419 0.0070182507 0.3496585048 0.739132557 7 36389821 36389861 41 + 0.673 0.539 -0.594
ENSG00000011426 E002 4.1708642 0.0055157982 0.1567745621 0.549294889 7 36389862 36389871 10 + 0.808 0.619 -0.779
ENSG00000011426 E003 29.4740824 0.0010391684 0.0604794948 0.372670788 7 36389872 36390005 134 + 1.544 1.437 -0.367
ENSG00000011426 E004 23.1656443 0.0111687367 0.3079068347 0.706219323 7 36390006 36390044 39 + 1.418 1.348 -0.242
ENSG00000011426 E005 0.1125166 0.0324341666 0.5938578962   7 36390171 36390211 41 + 0.109 0.000 -11.886
ENSG00000011426 E006 0.1125166 0.0324341666 0.5938578962   7 36390235 36390541 307 + 0.109 0.000 -11.886
ENSG00000011426 E007 35.5851493 0.0007920537 0.0683047685 0.392090717 7 36396266 36396419 154 + 1.616 1.523 -0.317
ENSG00000011426 E008 0.3340335 0.0274424043 0.1582800142   7 36396420 36396421 2 + 0.000 0.231 12.440
ENSG00000011426 E009 29.4023369 0.0009587362 0.0204633140 0.238162333 7 36399079 36399218 140 + 1.551 1.414 -0.470
ENSG00000011426 E010 31.9098110 0.0012315720 0.0044729452 0.119839494 7 36399219 36399393 175 + 1.603 1.437 -0.568
ENSG00000011426 E011 0.1125166 0.0324341666 0.5938578962   7 36403493 36403566 74 + 0.109 0.000 -11.886
ENSG00000011426 E012 39.4454418 0.0041758543 0.1779307489 0.576729647 7 36406181 36406401 221 + 1.655 1.581 -0.250
ENSG00000011426 E013 15.3926349 0.0017025517 0.3729780761 0.755267907 7 36406402 36406402 1 + 1.252 1.188 -0.227
ENSG00000011426 E014 32.7217841 0.0010045195 0.0622484454 0.377608362 7 36406403 36406532 130 + 1.584 1.484 -0.342
ENSG00000011426 E015 19.6280823 0.0016513663 0.1275904895 0.506598597 7 36406533 36406550 18 + 1.372 1.268 -0.361
ENSG00000011426 E016 18.0793109 0.0024228674 0.1011908932 0.459504596 7 36406551 36406566 16 + 1.345 1.225 -0.419
ENSG00000011426 E017 0.1767706 0.0556175361 0.5917350110   7 36406567 36406570 4 + 0.110 0.000 -11.681
ENSG00000011426 E018 0.1544607 0.0326491905 0.4106287475   7 36407718 36407733 16 + 0.000 0.131 11.410
ENSG00000011426 E019 45.1521305 0.0152427140 0.3626814687 0.748921051 7 36407734 36407956 223 + 1.684 1.653 -0.106
ENSG00000011426 E020 22.6898769 0.0034466534 0.8687180794 0.967731494 7 36410514 36410559 46 + 1.378 1.383 0.017
ENSG00000011426 E021 31.3324836 0.0031733880 0.5001665755 0.829733738 7 36410560 36410655 96 + 1.529 1.503 -0.091
ENSG00000011426 E022 27.5765933 0.0011488046 0.3012930811 0.700871524 7 36410656 36410704 49 + 1.491 1.437 -0.187
ENSG00000011426 E023 40.3629208 0.0007387678 0.4029979531 0.775533194 7 36411059 36411166 108 + 1.639 1.606 -0.114
ENSG00000011426 E024 50.1988304 0.0009084057 0.9700033306 0.993042225 7 36415758 36415884 127 + 1.714 1.727 0.043
ENSG00000011426 E025 0.5512620 0.0219622504 0.8506177721   7 36415885 36415885 1 + 0.196 0.231 0.303
ENSG00000011426 E026 38.1119144 0.0008251831 0.9629704768 0.991493052 7 36417080 36417190 111 + 1.594 1.602 0.027
ENSG00000011426 E027 70.7697792 0.0005246911 0.6999107755 0.915006820 7 36419244 36419467 224 + 1.854 1.880 0.086
ENSG00000011426 E028 23.6449687 0.0011456319 0.7707728789 0.939707356 7 36419468 36419479 12 + 1.383 1.414 0.108
ENSG00000011426 E029 37.8619964 0.0007917773 0.7851766681 0.943723518 7 36420169 36420223 55 + 1.603 1.598 -0.017
ENSG00000011426 E030 47.2927782 0.0005811711 0.9435234875 0.986848363 7 36420224 36420314 91 + 1.690 1.697 0.025
ENSG00000011426 E031 25.7894206 0.0023479015 0.9396812469 0.985860065 7 36420597 36420611 15 + 1.427 1.447 0.071
ENSG00000011426 E032 60.2827802 0.0038632685 0.9587633171 0.990492531 7 36420612 36420744 133 + 1.790 1.808 0.060
ENSG00000011426 E033 63.4723930 0.0055181730 0.3000523396 0.699936275 7 36421857 36421992 136 + 1.789 1.854 0.221
ENSG00000011426 E034 48.9197999 0.0098011126 0.5433763724 0.851533936 7 36422633 36422722 90 + 1.683 1.732 0.165
ENSG00000011426 E035 34.4401256 0.0008339100 0.7464615175 0.931637684 7 36422723 36422809 87 + 1.561 1.554 -0.026
ENSG00000011426 E036 45.6328599 0.0115059283 0.5747803782 0.864396978 7 36423817 36423943 127 + 1.658 1.690 0.108
ENSG00000011426 E037 36.5552728 0.0058929119 0.9154828154 0.979813480 7 36424545 36424593 49 + 1.571 1.582 0.036
ENSG00000011426 E038 40.2691755 0.0010089696 0.9993741517 0.999844783 7 36424686 36424742 57 + 1.618 1.628 0.032
ENSG00000011426 E039 37.9459500 0.0008370168 0.4887381248 0.823833656 7 36425702 36425740 39 + 1.610 1.582 -0.093
ENSG00000011426 E040 35.8057626 0.0010202637 0.4971965210 0.827966963 7 36426015 36426036 22 + 1.585 1.558 -0.092
ENSG00000011426 E041 43.4415925 0.0007214053 0.4071323149 0.778301267 7 36426916 36427028 113 + 1.667 1.635 -0.109
ENSG00000011426 E042 1.7507151 0.0102853132 0.5564443584 0.856577968 7 36428307 36428360 54 + 0.386 0.492 0.560
ENSG00000011426 E043 36.0591434 0.0043118678 0.5542477871 0.855602983 7 36439204 36439290 87 + 1.582 1.553 -0.101
ENSG00000011426 E044 55.6834598 0.0013785019 0.5036311514 0.831609929 7 36443755 36443862 108 + 1.734 1.780 0.156
ENSG00000011426 E045 10.4929492 0.0459608183 0.0000167771 0.004391969 7 36448939 36449664 726 + 0.651 1.277 2.364
ENSG00000011426 E046 97.9879233 0.0004201361 0.0730803960 0.402308551 7 36449665 36449837 173 + 1.964 2.039 0.251
ENSG00000011426 E047 296.6692124 0.0041387095 0.0037208929 0.109401250 7 36452477 36453791 1315 + 2.426 2.525 0.329