ENSG00000011260

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225298 ENSG00000011260 HEK293_DMSO_6hA HEK293_OSMI2_6hA UTP18 protein_coding protein_coding 47.58122 18.54976 16.24826 5.091556 2.184554 -0.1910048 45.113594 15.867837 15.1814945 4.2398469 1.8942591 -0.06375057 0.93503750 0.85843333 0.93753333 0.0791 0.04743001 0.04743001 FALSE  
ENST00000582150 ENSG00000011260 HEK293_DMSO_6hA HEK293_OSMI2_6hA UTP18 protein_coding retained_intron 47.58122 18.54976 16.24826 5.091556 2.184554 -0.1910048 0.696251 1.495768 0.4989737 0.2326825 0.1100208 -1.56483614 0.02245833 0.08536667 0.03136667 -0.0540 0.08651000 0.04743001    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000011260 E001 14.420886 0.0019261959 2.985146e-03 9.828444e-02 17 51260546 51260549 4 + 1.316 1.055 -0.930
ENSG00000011260 E002 136.161023 0.0029066743 1.315674e-02 1.975704e-01 17 51260550 51260926 377 + 2.190 2.090 -0.336
ENSG00000011260 E003 112.047029 0.0003305737 3.807480e-01 7.605459e-01 17 51263274 51263386 113 + 2.067 2.038 -0.097
ENSG00000011260 E004 117.752266 0.0003007251 2.711332e-01 6.752904e-01 17 51266182 51266280 99 + 2.095 2.060 -0.117
ENSG00000011260 E005 103.566457 0.0022186019 9.526681e-01 9.889914e-01 17 51268837 51268904 68 + 2.017 2.016 -0.002
ENSG00000011260 E006 107.631132 0.0003068552 2.458350e-01 6.514285e-01 17 51273362 51273450 89 + 2.058 2.019 -0.130
ENSG00000011260 E007 54.825720 0.0013503857 4.159198e-01 7.840437e-01 17 51275866 51275867 2 + 1.773 1.731 -0.142
ENSG00000011260 E008 139.972923 0.0002792127 8.855921e-01 9.726884e-01 17 51275868 51275991 124 + 2.151 2.147 -0.016
ENSG00000011260 E009 96.109341 0.0021507637 4.942065e-01 8.264473e-01 17 51277130 51277162 33 + 1.999 1.972 -0.092
ENSG00000011260 E010 156.722334 0.0002501917 4.967734e-01 8.277029e-01 17 51277163 51277304 142 + 2.188 2.206 0.060
ENSG00000011260 E011 80.997668 0.0003959629 2.306812e-01 6.356503e-01 17 51280005 51280015 11 + 1.891 1.936 0.153
ENSG00000011260 E012 122.967671 0.0002786021 4.172056e-01 7.848192e-01 17 51280016 51280105 90 + 2.109 2.083 -0.087
ENSG00000011260 E013 114.002992 0.0004032404 8.041784e-01 9.496352e-01 17 51280389 51280449 61 + 2.059 2.065 0.023
ENSG00000011260 E014 77.748632 0.0004121164 1.141407e-01 4.827253e-01 17 51280450 51280479 30 + 1.860 1.921 0.208
ENSG00000011260 E015 77.790284 0.0003992807 3.465485e-01 7.364801e-01 17 51285245 51285267 23 + 1.877 1.914 0.122
ENSG00000011260 E016 140.304155 0.0002158302 5.835149e-01 8.683475e-01 17 51285268 51285368 101 + 2.141 2.156 0.052
ENSG00000011260 E017 1.990943 0.0096955314 5.685533e-01 8.617115e-01 17 51286483 51286552 70 + 0.431 0.527 0.477
ENSG00000011260 E018 136.347484 0.0002792867 8.557026e-01 9.644455e-01 17 51288029 51288123 95 + 2.135 2.141 0.018
ENSG00000011260 E019 130.440673 0.0028840398 4.555792e-01 8.064617e-01 17 51288124 51288203 80 + 2.133 2.108 -0.085
ENSG00000011260 E020 1.579697 0.0111155756 1.368931e-02   17 51288548 51288591 44 + 0.127 0.563 2.966
ENSG00000011260 E021 157.366833 0.0002051190 7.528576e-01 9.335128e-01 17 51293903 51294045 143 + 2.194 2.202 0.028
ENSG00000011260 E022 24.299537 0.0053165929 1.802992e-08 2.536271e-05 17 51296255 51296964 710 + 1.076 1.543 1.636
ENSG00000011260 E023 97.170547 0.0003529073 3.260875e-01 7.216243e-01 17 51296965 51297003 39 + 1.969 2.004 0.116
ENSG00000011260 E024 87.712951 0.0052046929 1.464842e-01 5.343463e-01 17 51297782 51297936 155 + 1.903 1.972 0.233