ENSG00000010256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000203407 ENSG00000010256 HEK293_DMSO_6hA HEK293_OSMI2_6hA UQCRC1 protein_coding protein_coding 581.2236 526.1997 842.8884 72.62929 174.006 0.679721 261.4694 217.8197 400.1425 30.47844 88.25253 0.8773493 0.4340000 0.4136667 0.4708667 0.05720000 0.02041102 0.02041102 FALSE TRUE
ENST00000460105 ENSG00000010256 HEK293_DMSO_6hA HEK293_OSMI2_6hA UQCRC1 protein_coding retained_intron 581.2236 526.1997 842.8884 72.62929 174.006 0.679721 134.3318 125.5789 204.2622 15.84853 43.34402 0.7017841 0.2347208 0.2397333 0.2415333 0.00180000 0.97099832 0.02041102 FALSE FALSE
ENST00000472438 ENSG00000010256 HEK293_DMSO_6hA HEK293_OSMI2_6hA UQCRC1 protein_coding retained_intron 581.2236 526.1997 842.8884 72.62929 174.006 0.679721 166.2501 154.9399 216.4212 23.06609 43.85727 0.4821063 0.2926625 0.2934000 0.2572333 -0.03616667 0.06777834 0.02041102 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000010256 E001 1.0492591 1.446700e-01 0.122938631   3 48598991 48599001 11 - 0.177 0.469 1.956
ENSG00000010256 E002 23.8164370 6.552473e-03 0.757685290 0.93508870 3 48599002 48599003 2 - 1.387 1.410 0.079
ENSG00000010256 E003 541.6084236 1.400182e-03 0.285299675 0.68775147 3 48599004 48599033 30 - 2.740 2.717 -0.076
ENSG00000010256 E004 898.1958299 1.959576e-04 0.078106682 0.41378418 3 48599034 48599053 20 - 2.962 2.936 -0.088
ENSG00000010256 E005 2956.0005005 2.499003e-04 0.342114566 0.73359560 3 48599054 48599192 139 - 3.461 3.474 0.043
ENSG00000010256 E006 134.8066080 1.082982e-01 0.052126498 0.35023436 3 48599193 48599634 442 - 1.980 2.270 0.972
ENSG00000010256 E007 3091.8444711 5.532567e-05 0.107593290 0.47100619 3 48599635 48599710 76 - 3.482 3.492 0.032
ENSG00000010256 E008 2754.6776174 3.710869e-05 0.195397947 0.59826278 3 48600063 48600117 55 - 3.434 3.440 0.021
ENSG00000010256 E009 2676.0967773 5.966586e-05 0.162441990 0.55724280 3 48600118 48600151 34 - 3.422 3.429 0.025
ENSG00000010256 E010 3540.0851603 8.126579e-05 0.073043594 0.40221915 3 48600482 48600567 86 - 3.541 3.552 0.037
ENSG00000010256 E011 5280.7953275 2.849249e-05 0.169008274 0.56591309 3 48600680 48600840 161 - 3.717 3.722 0.015
ENSG00000010256 E012 112.2207229 1.040058e-01 0.037595252 0.30595455 3 48600841 48600974 134 - 1.887 2.201 1.055
ENSG00000010256 E013 4952.8034740 4.153097e-05 0.336304866 0.72910934 3 48600975 48601118 144 - 3.694 3.687 -0.024
ENSG00000010256 E014 2894.6480305 4.722981e-05 0.003910451 0.11184683 3 48601352 48601405 54 - 3.469 3.445 -0.078
ENSG00000010256 E015 3284.1391758 9.339642e-05 0.078929361 0.41526878 3 48601406 48601467 62 - 3.519 3.505 -0.046
ENSG00000010256 E016 56.4921196 4.140979e-03 0.083334458 0.42465348 3 48601468 48601470 3 - 1.708 1.810 0.345
ENSG00000010256 E017 13.4305574 2.097731e-03 0.634228465 0.88974577 3 48603563 48603563 1 - 1.180 1.131 -0.176
ENSG00000010256 E018 3472.2796659 7.572180e-05 0.201604833 0.60521580 3 48603564 48603643 80 - 3.542 3.532 -0.036
ENSG00000010256 E019 8.3108298 1.163090e-02 0.827017360 0.95610422 3 48603644 48603644 1 - 0.977 0.945 -0.121
ENSG00000010256 E020 10.6058903 5.078093e-02 0.245499541 0.65110015 3 48603998 48604232 235 - 0.980 1.144 0.598
ENSG00000010256 E021 2798.2552974 4.951833e-05 0.152264743 0.54234221 3 48604233 48604262 30 - 3.441 3.449 0.026
ENSG00000010256 E022 5171.4620670 1.828629e-04 0.021858794 0.24461094 3 48604263 48604431 169 - 3.699 3.722 0.078
ENSG00000010256 E023 12.8268326 4.664415e-02 0.421613430 0.78704435 3 48604432 48604650 219 - 1.059 1.205 0.523
ENSG00000010256 E024 4380.7389675 1.999933e-04 0.231622816 0.63668139 3 48604651 48604780 130 - 3.630 3.645 0.048
ENSG00000010256 E025 8.9081793 2.914878e-03 0.298847412 0.69902470 3 48604781 48604786 6 - 0.940 1.048 0.399
ENSG00000010256 E026 3257.3803979 6.304255e-05 0.547341466 0.85292824 3 48605770 48605856 87 - 3.511 3.506 -0.018
ENSG00000010256 E027 3245.3044708 3.961923e-04 0.029145608 0.27622891 3 48609162 48609302 141 - 3.514 3.497 -0.057
ENSG00000010256 E028 0.1717682 3.302623e-02 0.328110050   3 48609495 48609496 2 - 0.000 0.143 11.111
ENSG00000010256 E029 13.1292467 2.420096e-03 0.159574187 0.55370799 3 48609497 48609546 50 - 1.098 1.221 0.439
ENSG00000010256 E030 8.7920935 2.878250e-02 0.557094367 0.85693181 3 48609547 48609551 5 - 0.969 1.033 0.233
ENSG00000010256 E031 1552.0314889 1.297304e-03 0.001879947 0.07713607 3 48609552 48609595 44 - 3.209 3.155 -0.177
ENSG00000010256 E032 1151.9169151 2.499062e-03 0.006263983 0.14022507 3 48609596 48610005 410 - 3.082 3.021 -0.203
ENSG00000010256 E033 0.1544607 7.190054e-02 0.329489840   3 48610820 48611211 392 - 0.000 0.143 11.106