ENSG00000005801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005082 ENSG00000005801 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF195 protein_coding protein_coding 12.68971 6.726757 5.730856 1.629507 0.7158401 -0.2307884 2.8522394 1.601394 0.9919747 0.6316304 0.5261848 -0.68546364 0.21407500 0.22136667 0.1620333 -0.059333333 0.7562902581 0.0006129286 FALSE  
ENST00000354599 ENSG00000005801 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF195 protein_coding protein_coding 12.68971 6.726757 5.730856 1.629507 0.7158401 -0.2307884 3.5225197 2.017852 2.0664059 0.5510932 0.2578617 0.03413582 0.30274167 0.30283333 0.3639000 0.061066667 0.7503656166 0.0006129286 FALSE  
ENST00000526598 ENSG00000005801 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF195 protein_coding retained_intron 12.68971 6.726757 5.730856 1.629507 0.7158401 -0.2307884 0.1348257 0.454815 0.0000000 0.1764589 0.0000000 -5.53858465 0.01290417 0.06276667 0.0000000 -0.062766667 0.0006129286 0.0006129286    
ENST00000526601 ENSG00000005801 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF195 protein_coding protein_coding 12.68971 6.726757 5.730856 1.629507 0.7158401 -0.2307884 1.5669253 0.553777 0.6390645 0.2769358 0.1123620 0.20323733 0.11706667 0.10973333 0.1173000 0.007566667 0.8474769059 0.0006129286 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000005801 E001 7.9248771 0.0076194006 8.100583e-03 0.157145816 11 3339261 3339822 562 - 1.107 0.798 -1.159
ENSG00000005801 E002 3.1101678 0.0415969295 6.260115e-01 0.886474598 11 3355830 3355906 77 - 0.648 0.561 -0.384
ENSG00000005801 E003 0.9964960 0.1115792256 7.443446e-01   11 3357927 3357927 1 - 0.249 0.312 0.442
ENSG00000005801 E004 4.1470217 0.0119972802 1.678728e-02 0.219307603 11 3357928 3358102 175 - 0.875 0.528 -1.455
ENSG00000005801 E005 14.6688662 0.0190164732 1.494096e-01 0.538656400 11 3358103 3358410 308 - 1.269 1.125 -0.512
ENSG00000005801 E006 11.7912190 0.0213360676 6.995898e-01 0.914925097 11 3358411 3358468 58 - 1.066 1.124 0.209
ENSG00000005801 E007 63.9351340 0.0245725840 9.087567e-01 0.978152069 11 3358469 3358944 476 - 1.801 1.799 -0.007
ENSG00000005801 E008 24.1947676 0.0016597013 3.598300e-01 0.746742467 11 3358945 3358993 49 - 1.430 1.364 -0.227
ENSG00000005801 E009 33.5979058 0.0009225626 7.104548e-01 0.918907386 11 3358994 3359116 123 - 1.543 1.517 -0.088
ENSG00000005801 E010 182.7017191 0.0001861231 4.188257e-01 0.785604183 11 3359117 3359996 880 - 2.268 2.245 -0.076
ENSG00000005801 E011 34.0809720 0.0011094191 6.593182e-01 0.900401517 11 3359997 3360038 42 - 1.561 1.531 -0.102
ENSG00000005801 E012 59.7382013 0.0011690052 1.535513e-01 0.544258180 11 3360039 3360282 244 - 1.820 1.749 -0.239
ENSG00000005801 E013 20.8469391 0.0012874855 5.187193e-01 0.839456504 11 3360283 3360315 33 - 1.363 1.312 -0.178
ENSG00000005801 E014 15.2757987 0.0017453864 6.906280e-01 0.911993725 11 3360316 3360319 4 - 1.221 1.183 -0.134
ENSG00000005801 E015 16.1273369 0.0017466384 7.068612e-01 0.917725868 11 3360320 3360343 24 - 1.240 1.205 -0.125
ENSG00000005801 E016 10.1377774 0.0026838688 4.389671e-01 0.797100155 11 3360344 3360349 6 - 1.081 0.999 -0.302
ENSG00000005801 E017 13.9123131 0.0022103190 1.251428e-01 0.502624722 11 3360350 3360384 35 - 1.240 1.100 -0.499
ENSG00000005801 E018 12.5914427 0.0021170451 4.326067e-01 0.793223972 11 3360385 3360410 26 - 1.168 1.091 -0.274
ENSG00000005801 E019 11.3650885 0.0024481976 2.047605e-01 0.608534358 11 3360411 3360415 5 - 1.156 1.032 -0.451
ENSG00000005801 E020 13.0066522 0.0022443528 2.435292e-01 0.648679069 11 3360416 3360424 9 - 1.200 1.091 -0.391
ENSG00000005801 E021 20.0676906 0.0015690752 9.115767e-01 0.978891350 11 3360425 3360452 28 - 1.318 1.306 -0.042
ENSG00000005801 E022 20.4645676 0.0013179979 6.602327e-02 0.386759394 11 3360453 3360477 25 - 1.230 1.369 0.487
ENSG00000005801 E023 34.8512949 0.0009130184 9.498687e-01 0.988289361 11 3360478 3360565 88 - 1.552 1.544 -0.026
ENSG00000005801 E024 8.5551760 0.0577251255 8.537515e-02 0.428970027 11 3360720 3360788 69 - 0.782 1.044 0.994
ENSG00000005801 E025 19.5312215 0.0014428057 1.076836e-01 0.471207286 11 3361743 3361782 40 - 1.221 1.344 0.434
ENSG00000005801 E026 14.1526166 0.0018273001 2.679363e-01 0.672404362 11 3361783 3361808 26 - 1.107 1.205 0.348
ENSG00000005801 E027 16.2888089 0.0068764237 4.501357e-01 0.803621070 11 3361809 3361889 81 - 1.180 1.251 0.250
ENSG00000005801 E028 7.0562202 0.0040955179 6.317449e-03 0.140650021 11 3361890 3361975 86 - 0.646 0.998 1.385
ENSG00000005801 E029 6.2130231 0.0049818411 3.405066e-03 0.105088106 11 3361976 3362017 42 - 0.564 0.963 1.617
ENSG00000005801 E030 5.5650659 0.0388926030 1.162929e-02 0.186488704 11 3362018 3362032 15 - 0.516 0.923 1.696
ENSG00000005801 E031 6.9305754 0.0097480839 8.879538e-04 0.050668014 11 3362033 3362073 41 - 0.564 1.020 1.833
ENSG00000005801 E032 8.9283719 0.0243757429 2.379531e-03 0.087178785 11 3362074 3362532 459 - 0.681 1.115 1.663
ENSG00000005801 E033 0.5359162 0.4219683521 8.451639e-01   11 3362533 3362545 13 - 0.143 0.186 0.456
ENSG00000005801 E034 2.1501676 0.0090483808 1.768176e-01 0.575187616 11 3362546 3362567 22 - 0.331 0.561 1.207
ENSG00000005801 E035 2.5218568 0.0078010828 4.223295e-01 0.787457668 11 3362568 3362602 35 - 0.463 0.591 0.609
ENSG00000005801 E036 20.1895918 0.0017738112 2.270212e-05 0.005312635 11 3362603 3363317 715 - 1.067 1.420 1.245
ENSG00000005801 E037 6.4179729 0.0058568229 8.614184e-02 0.430122571 11 3363318 3363391 74 - 0.715 0.936 0.866
ENSG00000005801 E038 39.8127702 0.0170734064 1.569632e-04 0.017612097 11 3363392 3366690 3299 - 1.384 1.690 1.046
ENSG00000005801 E039 4.0524757 0.0191618384 5.296505e-01 0.844744377 11 3366691 3366843 153 - 0.747 0.646 -0.419
ENSG00000005801 E040 3.9205388 0.0135431507 7.395905e-01 0.928988445 11 3366844 3366945 102 - 0.647 0.695 0.200
ENSG00000005801 E041 2.8596377 0.0479942033 1.649779e-01 0.560581495 11 3366946 3367057 112 - 0.405 0.646 1.150
ENSG00000005801 E042 15.0597968 0.0778740577 2.064373e-01 0.610395330 11 3367058 3368791 1734 - 1.074 1.247 0.616
ENSG00000005801 E043 2.2161199 0.0212104254 1.866210e-01 0.587546208 11 3368792 3368820 29 - 0.332 0.561 1.202
ENSG00000005801 E044 1.6813686 0.0169895067 2.526611e-03 0.089942469 11 3368821 3368855 35 - 0.000 0.561 11.298
ENSG00000005801 E045 2.2350646 0.1861603063 6.306975e-01 0.888357475 11 3369241 3369356 116 - 0.413 0.529 0.582
ENSG00000005801 E046 3.5636324 0.0074221558 3.886282e-01 0.766135360 11 3369357 3369502 146 - 0.564 0.695 0.567
ENSG00000005801 E047 0.7137611 0.3272399998 7.934679e-01   11 3370943 3370974 32 - 0.254 0.185 -0.576
ENSG00000005801 E048 13.7745448 0.0309760103 5.734989e-02 0.364646316 11 3370975 3370979 5 - 1.291 1.053 -0.845
ENSG00000005801 E049 30.6823959 0.0291950163 8.391072e-02 0.425588061 11 3370980 3371070 91 - 1.602 1.411 -0.654
ENSG00000005801 E050 0.0000000       11 3371071 3371147 77 -      
ENSG00000005801 E051 32.6886534 0.0339919690 1.219057e-01 0.497046173 11 3371577 3371703 127 - 1.622 1.444 -0.610
ENSG00000005801 E052 6.5583297 0.0883650150 3.138395e-01 0.711327629 11 3373577 3373656 80 - 0.971 0.783 -0.721
ENSG00000005801 E053 0.5080019 0.1339667040 4.088880e-01   11 3373657 3373675 19 - 0.249 0.101 -1.559
ENSG00000005801 E054 0.3563434 0.0309559407 7.971628e-01   11 3375497 3375662 166 - 0.140 0.102 -0.531
ENSG00000005801 E055 2.4224494 0.2624125367 2.765916e-01 0.680342687 11 3377617 3377802 186 - 0.693 0.410 -1.326
ENSG00000005801 E056 1.2115244 0.0135629921 3.460418e-01   11 3377803 3377900 98 - 0.245 0.412 1.058
ENSG00000005801 E057 23.7800714 0.0505041346 1.323812e-01 0.514006196 11 3379038 3379222 185 - 1.508 1.291 -0.750