ENSG00000002586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381192 ENSG00000002586 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD99 protein_coding protein_coding 295.9964 269.9102 384.5793 27.0719 44.41383 0.5107859 170.71914 161.2144 204.52172 16.152261 21.270530 0.3432548 0.5740208 0.5974000 0.53350000 -0.063900000 0.01252704 0.01252704 FALSE  
ENST00000624481 ENSG00000002586 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD99 protein_coding protein_coding 295.9964 269.9102 384.5793 27.0719 44.41383 0.5107859 21.80535 22.0194 29.25741 1.624336 3.665138 0.4098646 0.0741000 0.0822000 0.07596667 -0.006233333 0.74957775 0.01252704 FALSE  
MSTRG.33864.2 ENSG00000002586 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD99 protein_coding   295.9964 269.9102 384.5793 27.0719 44.41383 0.5107859 79.07098 62.1662 120.04042 9.726055 16.943661 0.9492061 0.2679792 0.2277667 0.31033333 0.082566667 0.02143813 0.01252704 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000002586 E001 9.1229693 3.236997e-02 0.7905917271 0.94518394 X 2691158 2691181 24 + 0.990 1.033 0.158
ENSG00000002586 E002 21.7344576 1.935302e-02 0.3073572491 0.70562953 X 2691182 2691186 5 + 1.404 1.305 -0.342
ENSG00000002586 E003 277.8801265 5.266000e-03 0.0010948818 0.05701815 X 2691187 2691275 89 + 2.501 2.369 -0.439
ENSG00000002586 E004 254.7329418 2.251483e-03 0.0001170011 0.01472271 X 2691276 2691279 4 + 2.459 2.337 -0.409
ENSG00000002586 E005 297.7363657 1.611272e-03 0.0003745508 0.03011472 X 2691280 2691291 12 + 2.518 2.417 -0.335
ENSG00000002586 E006 282.0327632 2.221898e-03 0.0053459852 0.13073758 X 2691292 2691294 3 + 2.489 2.402 -0.288
ENSG00000002586 E007 424.6979492 1.904292e-04 0.0001834335 0.01939795 X 2691295 2691309 15 + 2.656 2.588 -0.226
ENSG00000002586 E008 433.1665538 2.992168e-04 0.0038732570 0.11125560 X 2691310 2691312 3 + 2.658 2.605 -0.177
ENSG00000002586 E009 511.5215174 5.595963e-04 0.0019951020 0.07952556 X 2691313 2691325 13 + 2.732 2.674 -0.192
ENSG00000002586 E010 973.5411215 8.128717e-04 0.0757895222 0.40856911 X 2691326 2691360 35 + 2.998 2.970 -0.093
ENSG00000002586 E011 1416.3517647 8.197298e-04 0.3251491770 0.72102516 X 2691361 2691427 67 + 3.154 3.142 -0.039
ENSG00000002586 E012 2.0514669 2.933313e-02 0.7077792678 0.91797968 X 2691481 2691499 19 + 0.429 0.500 0.360
ENSG00000002586 E013 25.7150468 7.480887e-03 0.7000252932 0.91503965 X 2691500 2691695 196 + 1.407 1.443 0.125
ENSG00000002586 E014 1.0421902 5.865931e-02 0.6151376300   X 2691788 2692253 466 + 0.329 0.235 -0.657
ENSG00000002586 E015 1411.9540873 5.107297e-04 0.8406312120 0.96054500 X 2714422 2714454 33 + 3.143 3.150 0.023
ENSG00000002586 E016 28.5642049 7.846140e-02 0.1985981163 0.60176464 X 2714455 2715597 1143 + 1.388 1.542 0.527
ENSG00000002586 E017 9.7646054 5.128971e-03 0.0706581243 0.39709851 X 2717374 2717474 101 + 0.931 1.122 0.700
ENSG00000002586 E018 1763.5477615 1.966773e-04 0.9515842099 0.98870177 X 2717605 2717652 48 + 3.241 3.243 0.008
ENSG00000002586 E019 36.8784291 1.870904e-03 0.0043970632 0.11879960 X 2717653 2718018 366 + 1.482 1.653 0.583
ENSG00000002586 E020 30.6715342 6.138580e-02 0.2066672100 0.61059812 X 2719068 2719660 593 + 1.421 1.568 0.504
ENSG00000002586 E021 2008.3399852 5.517323e-05 0.7317957532 0.92632426 X 2719661 2719705 45 + 3.299 3.296 -0.009
ENSG00000002586 E022 2527.0895950 1.880515e-04 0.3425174877 0.73393733 X 2720356 2720424 69 + 3.394 3.404 0.032
ENSG00000002586 E023 2066.9632595 6.713514e-04 0.0566475101 0.36288455 X 2722627 2722674 48 + 3.298 3.327 0.097
ENSG00000002586 E024 2080.9012684 1.768052e-04 0.0028877203 0.09639832 X 2723314 2723364 51 + 3.299 3.329 0.100
ENSG00000002586 E025 3.2559635 3.321232e-01 0.1075555133 0.47093586 X 2723365 2723434 70 + 0.389 0.799 1.868
ENSG00000002586 E026 2336.6075323 2.937865e-04 0.8957399127 0.97504146 X 2726260 2726340 81 + 3.363 3.366 0.011
ENSG00000002586 E027 1684.5212870 1.113932e-04 0.5671403246 0.86096841 X 2726341 2726373 33 + 3.218 3.225 0.021
ENSG00000002586 E028 0.5247464 1.493274e-01 0.4866682572   X 2727293 2727343 51 + 0.108 0.236 1.355
ENSG00000002586 E029 4.1212625 5.525458e-03 0.8067423885 0.95023209 X 2733357 2733374 18 + 0.691 0.726 0.147
ENSG00000002586 E030 7.1718183 6.975627e-03 0.6179978408 0.88315327 X 2733375 2733672 298 + 0.871 0.933 0.236
ENSG00000002586 E031 16.9213642 2.249296e-02 0.0039417446 0.11238516 X 2737881 2738199 319 + 1.086 1.387 1.065
ENSG00000002586 E032 1195.8482124 5.065375e-05 0.2677992427 0.67225493 X 2738200 2738202 3 + 3.067 3.079 0.039
ENSG00000002586 E033 1874.1624351 5.944958e-05 0.6199538286 0.88405854 X 2738203 2738256 54 + 3.270 3.266 -0.013
ENSG00000002586 E034 4094.8811340 3.953918e-04 0.1183702173 0.49076787 X 2740779 2741217 439 + 3.602 3.619 0.056
ENSG00000002586 E035 392.3179979 3.151652e-03 0.1755010953 0.57346461 X 2741218 2741309 92 + 2.575 2.614 0.131
ENSG00000002586 E036 1.1805693 1.391547e-02 0.0228864667   X 2741570 2741599 30 + 0.107 0.500 2.951