ENSG00000224940

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446477 ENSG00000224940 HEK293_DMSO_2hA HEK293_OSMI2_2hA PRRT4 protein_coding protein_coding 2.609919 3.110767 3.988381 0.4971032 0.5524798 0.3575151 0.5705189 1.3265082 0.4660698 0.05292910 0.09968836 -1.4892236 0.2161042 0.4519667 0.1158000 -0.3361667 0.003916347 0.003916347 FALSE TRUE
ENST00000480290 ENSG00000224940 HEK293_DMSO_2hA HEK293_OSMI2_2hA PRRT4 protein_coding protein_coding 2.609919 3.110767 3.988381 0.4971032 0.5524798 0.3575151 0.4389349 0.2451510 0.9997331 0.24515104 0.23569218 1.9845505 0.1511667 0.0626000 0.2427333 0.1801333 0.533873965 0.003916347 FALSE TRUE
ENST00000489517 ENSG00000224940 HEK293_DMSO_2hA HEK293_OSMI2_2hA PRRT4 protein_coding protein_coding 2.609919 3.110767 3.988381 0.4971032 0.5524798 0.3575151 0.5275448 0.1800315 0.7483116 0.09056507 0.23937457 1.9965525 0.2009083 0.0507000 0.1768667 0.1261667 0.534044381 0.003916347 FALSE TRUE
ENST00000489835 ENSG00000224940 HEK293_DMSO_2hA HEK293_OSMI2_2hA PRRT4 protein_coding protein_coding 2.609919 3.110767 3.988381 0.4971032 0.5524798 0.3575151 1.0729208 1.3590766 1.7742664 0.23506288 0.08352993 0.3821278 0.4318125 0.4347667 0.4645667 0.0298000 0.977932260 0.003916347 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000224940 E001 0.2103315 0.034500207 3.104809e-01   7 128350325 128350325 1 - 0.000 0.150 8.812
ENSG00000224940 E002 2.0432372 0.009366751 4.312071e-01 0.99995031 7 128350326 128350353 28 - 0.406 0.542 0.682
ENSG00000224940 E003 58.3930507 0.008054309 7.594075e-01 0.99995031 7 128350354 128350855 502 - 1.779 1.764 -0.049
ENSG00000224940 E004 32.2785350 0.003439811 1.560949e-01 0.99995031 7 128350856 128351024 169 - 1.564 1.476 -0.299
ENSG00000224940 E005 43.4192777 0.001009469 7.344748e-01 0.99995031 7 128351025 128351414 390 - 1.650 1.635 -0.050
ENSG00000224940 E006 16.8271715 0.005003343 2.015649e-01 0.99995031 7 128351415 128351678 264 - 1.190 1.302 0.394
ENSG00000224940 E007 9.2148967 0.002465522 5.855623e-05 0.08675726 7 128351679 128352116 438 - 0.731 1.178 1.682
ENSG00000224940 E008 15.0240454 0.087078212 1.612685e-01 0.99995031 7 128352117 128352448 332 - 1.089 1.287 0.703
ENSG00000224940 E009 33.5622969 0.001073452 3.446651e-01 0.99995031 7 128352449 128352678 230 - 1.505 1.563 0.200
ENSG00000224940 E010 22.2872384 0.001338431 8.117239e-01 0.99995031 7 128358681 128358737 57 - 1.355 1.376 0.070
ENSG00000224940 E011 18.2630391 0.001353828 9.951908e-02 0.99995031 7 128358738 128358800 63 - 1.341 1.212 -0.450
ENSG00000224940 E012 20.7407027 0.001486541 7.422972e-01 0.99995031 7 128359149 128359253 105 - 1.341 1.319 -0.075
ENSG00000224940 E013 14.0204513 0.001952352 8.566098e-01 0.99995031 7 128359340 128359374 35 - 1.159 1.178 0.067
ENSG00000224940 E014 49.1173553 0.011990641 3.125993e-01 0.99995031 7 128359375 128360063 689 - 1.730 1.662 -0.230
ENSG00000224940 E015 6.3249553 0.003471829 4.269518e-01 0.99995031 7 128361306 128361422 117 - 0.902 0.805 -0.375
ENSG00000224940 E016 4.0704877 0.005096673 1.685847e-01 0.99995031 7 128361423 128361560 138 - 0.790 0.591 -0.834
ENSG00000224940 E017 3.1129213 0.006409870 7.584281e-01 0.99995031 7 128361561 128361711 151 - 0.584 0.634 0.221