ENSG00000205309

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389022 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding protein_coding 7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 0.3930460 1.7747029 0.0000000 0.4175014 0.0000000 -7.4795401 0.05212500 0.1462000 0.00000000 -0.14620000 2.771112e-11 2.771112e-11 FALSE TRUE
ENST00000478373 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding nonsense_mediated_decay 7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 1.1987065 2.3780543 1.7200166 0.2139184 0.4025671 -0.4650497 0.16955833 0.1953667 0.12083333 -0.07453333 7.452864e-01 2.771112e-11 TRUE FALSE
ENST00000483704 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding nonsense_mediated_decay 7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 0.5181667 1.0552176 1.3732433 0.5302850 0.2715006 0.3769068 0.06416250 0.0877000 0.09930000 0.01160000 9.247268e-01 2.771112e-11 FALSE TRUE
ENST00000582909 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding processed_transcript 7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 0.3485277 0.4083856 1.9488006 0.4083856 1.0451083 2.2270654 0.03909167 0.0339000 0.12906667 0.09516667 9.229573e-01 2.771112e-11 FALSE TRUE
ENST00000616989 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding protein_coding 7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 1.0559471 1.2053240 1.9538406 0.6063107 0.2670972 0.6923369 0.13352083 0.0894000 0.13950000 0.05010000 9.229573e-01 2.771112e-11 FALSE TRUE
MSTRG.13760.5 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding   7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 0.6470430 1.2998956 0.6373739 0.6519347 0.3251850 -1.0167807 0.09971667 0.1172333 0.04666667 -0.07056667 9.275716e-01 2.771112e-11 FALSE TRUE
MSTRG.13760.9 ENSG00000205309 HEK293_DMSO_2hA HEK293_OSMI2_2hA NT5M protein_coding   7.399297 12.43758 14.24466 1.417314 0.8099125 0.1955687 2.1559907 2.3955122 4.5949232 1.2309874 0.3789190 0.9368330 0.30640417 0.1762333 0.32286667 0.14663333 9.229573e-01 2.771112e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000205309 E001 1.6215691 0.0105863133 8.959431e-01   17 17303335 17303365 31 + 0.406 0.425 0.102
ENSG00000205309 E002 2.4522716 0.0077065756 8.736999e-01 0.99995031 17 17303366 17303372 7 + 0.521 0.543 0.102
ENSG00000205309 E003 5.3203478 0.0809871117 4.075725e-01 0.99995031 17 17303373 17303389 17 + 0.719 0.857 0.549
ENSG00000205309 E004 21.0884802 0.0628271523 2.617249e-02 0.93191272 17 17303390 17303664 275 + 1.180 1.459 0.973
ENSG00000205309 E005 13.6963449 0.0017761876 3.072667e-05 0.06520019 17 17303665 17303677 13 + 0.940 1.320 1.367
ENSG00000205309 E006 47.1235522 0.0013445184 2.337183e-03 0.46639567 17 17303678 17303817 140 + 1.603 1.753 0.507
ENSG00000205309 E007 25.1893911 0.0012121844 2.803857e-02 0.94317140 17 17303818 17303901 84 + 1.339 1.484 0.498
ENSG00000205309 E008 2.4003470 0.0073301328 2.800909e-01 0.99995031 17 17304342 17304363 22 + 0.612 0.425 -0.897
ENSG00000205309 E009 15.1435916 0.0023491191 2.340910e-01 0.99995031 17 17304364 17304477 114 + 1.267 1.154 -0.397
ENSG00000205309 E010 0.8544116 0.0153505034 2.645489e-01   17 17304478 17304481 4 + 0.359 0.151 -1.632
ENSG00000205309 E011 57.7517197 0.0006268627 4.441128e-01 0.99995031 17 17306543 17306643 101 + 1.792 1.749 -0.144
ENSG00000205309 E012 55.1461098 0.0011314311 8.790932e-01 0.99995031 17 17323185 17323245 61 + 1.762 1.746 -0.053
ENSG00000205309 E013 7.6001135 0.0144672790 4.025160e-02 0.99673612 17 17333496 17333510 15 + 0.790 1.040 0.949
ENSG00000205309 E014 10.9790774 0.0027731288 3.749432e-01 0.99995031 17 17333511 17333588 78 + 1.033 1.115 0.298
ENSG00000205309 E015 76.5236138 0.0005364392 1.189280e-01 0.99995031 17 17344794 17344908 115 + 1.925 1.857 -0.229
ENSG00000205309 E016 16.8547730 0.0016208434 2.148618e-01 0.99995031 17 17344909 17344926 18 + 1.302 1.191 -0.392
ENSG00000205309 E017 1.5097398 0.0717480659 8.444817e-01   17 17345269 17345312 44 + 0.402 0.424 0.123
ENSG00000205309 E018 236.7999721 0.0044010951 1.541386e-02 0.83687587 17 17346805 17347663 859 + 2.413 2.340 -0.243