ENSG00000197451

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355836 ENSG00000197451 HEK293_DMSO_2hA HEK293_OSMI2_2hA HNRNPAB protein_coding protein_coding 495.5162 702.9817 659.7572 28.06705 26.9882 -0.09155062 164.07032 228.66045 237.06285 4.130174 9.042862 0.05206052 0.33119167 0.3266667 0.35970000 0.03303333 0.91023792 0.02710743 FALSE  
ENST00000358344 ENSG00000197451 HEK293_DMSO_2hA HEK293_OSMI2_2hA HNRNPAB protein_coding protein_coding 495.5162 702.9817 659.7572 28.06705 26.9882 -0.09155062 285.72335 397.77385 387.85529 18.448676 18.485960 -0.03642901 0.57868750 0.5655333 0.58753333 0.02200000 0.57496121 0.02710743 FALSE  
ENST00000506259 ENSG00000197451 HEK293_DMSO_2hA HEK293_OSMI2_2hA HNRNPAB protein_coding protein_coding 495.5162 702.9817 659.7572 28.06705 26.9882 -0.09155062 37.47633 71.66268 29.22044 12.858570 6.214246 -1.29395183 0.07114583 0.1008333 0.04416667 -0.05666667 0.02710743 0.02710743 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000197451 E001 25.21661 0.0010207676 4.473318e-03 0.57535902 5 178203898 178204532 635 + 1.504 1.322 -0.630
ENSG00000197451 E002 30.79348 0.0009510136 1.223169e-01 0.99995031 5 178204533 178204538 6 + 1.543 1.462 -0.275
ENSG00000197451 E003 45.44022 0.0006545661 4.507733e-01 0.99995031 5 178204539 178204540 2 + 1.678 1.657 -0.073
ENSG00000197451 E004 114.60460 0.0003643569 9.319864e-01 0.99995031 5 178204541 178204543 3 + 2.055 2.071 0.053
ENSG00000197451 E005 474.96487 0.0127393626 2.905908e-01 0.99995031 5 178204544 178204547 4 + 2.631 2.716 0.282
ENSG00000197451 E006 837.15632 0.0152242158 8.802540e-02 0.99995031 5 178204548 178204570 23 + 2.853 2.980 0.424
ENSG00000197451 E007 1737.56603 0.0230069028 5.386201e-03 0.61115135 5 178204571 178204740 170 + 3.106 3.337 0.769
ENSG00000197451 E008 297.48586 0.0598275640 1.155534e-03 0.36562071 5 178204741 178204814 74 + 2.206 2.631 1.419
ENSG00000197451 E009 636.43586 0.0336708979 2.793343e-04 0.19215080 5 178204815 178204817 3 + 2.584 2.943 1.193
ENSG00000197451 E010 2675.90631 0.0170944808 3.399080e-03 0.53281183 5 178204818 178205046 229 + 3.309 3.516 0.688
ENSG00000197451 E011 26.41660 0.0010386616 3.144191e-01 0.99995031 5 178205568 178205841 274 + 1.393 1.480 0.298
ENSG00000197451 E012 5480.66069 0.0006034634 9.221469e-01 0.99995031 5 178205842 178206010 169 + 3.727 3.749 0.073
ENSG00000197451 E013 8137.42484 0.0004720029 5.290706e-05 0.08156564 5 178206732 178206890 159 + 3.919 3.902 -0.057
ENSG00000197451 E014 7588.28836 0.0007533368 1.014669e-04 0.11534081 5 178207094 178207225 132 + 3.893 3.868 -0.084
ENSG00000197451 E015 5675.02469 0.0016323413 1.464086e-02 0.82215741 5 178209330 178209432 103 + 3.766 3.743 -0.078
ENSG00000197451 E016 1175.64201 0.0038993345 3.382052e-01 0.99995031 5 178209433 178209441 9 + 3.077 3.065 -0.041
ENSG00000197451 E017 1064.23044 0.0043910257 5.790612e-01 0.99995031 5 178209442 178209447 6 + 3.028 3.028 -0.002
ENSG00000197451 E018 2286.59013 0.0013983440 7.588281e-02 0.99995031 5 178210132 178210272 141 + 3.367 3.353 -0.047
ENSG00000197451 E019 9554.46016 0.0021036112 4.983248e-01 0.99995031 5 178210553 178211163 611 + 3.975 3.985 0.034