ENSG00000185024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327359 ENSG00000185024 HEK293_DMSO_2hA HEK293_OSMI2_2hA BRF1 protein_coding protein_coding 29.90862 40.51269 45.81967 3.398755 3.337866 0.177552 2.687785 0.000000 3.040260 0.0000000 1.2418540 8.2527883 0.11097083 0.00000000 0.06356667 0.06356667 9.069842e-06 9.069842e-06 FALSE TRUE
ENST00000392557 ENSG00000185024 HEK293_DMSO_2hA HEK293_OSMI2_2hA BRF1 protein_coding protein_coding 29.90862 40.51269 45.81967 3.398755 3.337866 0.177552 3.289006 4.297739 5.661858 0.2694221 0.3868730 0.3968906 0.10977500 0.10710000 0.12366667 0.01656667 9.229573e-01 9.069842e-06 FALSE TRUE
ENST00000446501 ENSG00000185024 HEK293_DMSO_2hA HEK293_OSMI2_2hA BRF1 protein_coding protein_coding 29.90862 40.51269 45.81967 3.398755 3.337866 0.177552 10.351803 18.731021 21.522694 2.8064858 1.5180751 0.2003293 0.31358333 0.45733333 0.47166667 0.01433333 9.733165e-01 9.069842e-06 FALSE TRUE
ENST00000547530 ENSG00000185024 HEK293_DMSO_2hA HEK293_OSMI2_2hA BRF1 protein_coding protein_coding 29.90862 40.51269 45.81967 3.398755 3.337866 0.177552 2.929590 4.538320 3.601050 0.5075719 0.1933056 -0.3329154 0.09380417 0.11410000 0.07986667 -0.03423333 8.440431e-01 9.069842e-06 FALSE TRUE
MSTRG.10294.4 ENSG00000185024 HEK293_DMSO_2hA HEK293_OSMI2_2hA BRF1 protein_coding   29.90862 40.51269 45.81967 3.398755 3.337866 0.177552 2.772777 3.388764 3.726006 0.8320104 0.4764124 0.1364865 0.09557500 0.08173333 0.08073333 -0.00100000 9.973798e-01 9.069842e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000185024 E001 1.414820 0.2449781852 0.6488941180   14 105209286 105209288 3 - 0.341 0.438 0.547
ENSG00000185024 E002 160.254060 0.0091348061 0.2986380352 0.99995031 14 105209289 105209428 140 - 2.178 2.239 0.205
ENSG00000185024 E003 189.858633 0.0074737040 0.1409220056 0.99995031 14 105209429 105209495 67 - 2.245 2.318 0.242
ENSG00000185024 E004 365.739529 0.0026973441 0.6676227556 0.99995031 14 105209496 105209659 164 - 2.558 2.571 0.041
ENSG00000185024 E005 580.267381 0.0053625286 0.6314888854 0.99995031 14 105209660 105210077 418 - 2.773 2.755 -0.060
ENSG00000185024 E006 457.930182 0.0021922069 0.8008996924 0.99995031 14 105210078 105210277 200 - 2.659 2.665 0.021
ENSG00000185024 E007 311.945375 0.0002068928 0.8140779987 0.99995031 14 105210278 105210366 89 - 2.492 2.499 0.025
ENSG00000185024 E008 447.073446 0.0008340853 0.9258927823 0.99995031 14 105210367 105210588 222 - 2.651 2.650 -0.001
ENSG00000185024 E009 411.328939 0.0003675401 0.1783954570 0.99995031 14 105211122 105211293 172 - 2.626 2.602 -0.080
ENSG00000185024 E010 26.372733 0.0185361279 0.9527896770 0.99995031 14 105211294 105212112 819 - 1.436 1.437 0.005
ENSG00000185024 E011 265.319060 0.0004586412 0.6215908040 0.99995031 14 105212113 105212164 52 - 2.430 2.420 -0.033
ENSG00000185024 E012 2.842873 0.0066567758 0.6593229294 0.99995031 14 105212165 105213428 1264 - 0.624 0.555 -0.306
ENSG00000185024 E013 2.202166 0.4291971771 0.9627301788 0.99995031 14 105217213 105217278 66 - 0.491 0.502 0.055
ENSG00000185024 E014 272.603947 0.0047164363 0.6957603719 0.99995031 14 105217544 105217632 89 - 2.432 2.442 0.034
ENSG00000185024 E015 357.231391 0.0014820960 0.9768399611 0.99995031 14 105217633 105217800 168 - 2.553 2.552 -0.005
ENSG00000185024 E016 218.428472 0.0010532498 0.4412514354 0.99995031 14 105218998 105219053 56 - 2.348 2.329 -0.065
ENSG00000185024 E017 245.897962 0.0004196795 0.6922120685 0.99995031 14 105219151 105219232 82 - 2.385 2.397 0.041
ENSG00000185024 E018 9.888590 0.0030060334 0.1911407078 0.99995031 14 105219233 105219298 66 - 0.962 1.103 0.517
ENSG00000185024 E019 17.436671 0.0014252618 0.6646236229 0.99995031 14 105219299 105220068 770 - 1.244 1.282 0.134
ENSG00000185024 E020 189.589489 0.0003256134 0.6639341984 0.99995031 14 105220069 105220127 59 - 2.282 2.273 -0.030
ENSG00000185024 E021 92.579305 0.0005748473 0.3795499202 0.99995031 14 105220128 105220130 3 - 1.952 1.988 0.123
ENSG00000185024 E022 315.913222 0.0006589002 0.9172632306 0.99995031 14 105221648 105221884 237 - 2.499 2.498 -0.005
ENSG00000185024 E023 119.847535 0.0003514557 0.9161316965 0.99995031 14 105221885 105221914 30 - 2.081 2.080 -0.003
ENSG00000185024 E024 10.124854 0.0028099827 0.6132618222 0.99995031 14 105221915 105222545 631 - 1.016 1.072 0.203
ENSG00000185024 E025 107.331311 0.0004518833 0.9437167901 0.99995031 14 105226069 105226102 34 - 2.029 2.034 0.016
ENSG00000185024 E026 77.673521 0.0043610241 0.9374825907 0.99995031 14 105226103 105226113 11 - 1.892 1.896 0.014
ENSG00000185024 E027 72.461215 0.0032315175 0.9192953070 0.99995031 14 105226114 105226122 9 - 1.861 1.867 0.019
ENSG00000185024 E028 106.809327 0.0076057648 0.7423571850 0.99995031 14 105226123 105226161 39 - 2.042 2.019 -0.076
ENSG00000185024 E029 115.982787 0.0036787535 0.9205507087 0.99995031 14 105226251 105226290 40 - 2.070 2.064 -0.020
ENSG00000185024 E030 194.159766 0.0039716214 0.5452795036 0.99995031 14 105226634 105226760 127 - 2.302 2.276 -0.087
ENSG00000185024 E031 15.645090 0.0016519732 0.0000263266 0.06030026 14 105226761 105228270 1510 - 1.006 1.378 1.326
ENSG00000185024 E032 108.130191 0.0023454696 0.6373153276 0.99995031 14 105228820 105228860 41 - 2.045 2.025 -0.066
ENSG00000185024 E033 111.960206 0.0041494230 0.7951501992 0.99995031 14 105228861 105228913 53 - 2.056 2.044 -0.042
ENSG00000185024 E034 67.977672 0.0076870448 0.8582983340 0.99995031 14 105241265 105241304 40 - 1.841 1.831 -0.033
ENSG00000185024 E035 99.632431 0.0017580432 0.5800723930 0.99995031 14 105241305 105241414 110 - 2.010 1.988 -0.072
ENSG00000185024 E036 4.974059 0.0894089461 0.7657763029 0.99995031 14 105241415 105242605 1191 - 0.747 0.790 0.169
ENSG00000185024 E037 47.271299 0.0006804442 0.2305407973 0.99995031 14 105247071 105247287 217 - 1.711 1.650 -0.207
ENSG00000185024 E038 103.776088 0.0005105230 0.0006583948 0.29049536 14 105247288 105248074 787 - 2.074 1.950 -0.415
ENSG00000185024 E039 37.230568 0.0322885553 0.8205559886 0.99995031 14 105248075 105249148 1074 - 1.597 1.563 -0.117
ENSG00000185024 E040 10.420893 0.0023405975 0.1058294357 0.99995031 14 105249149 105249404 256 - 0.962 1.131 0.620
ENSG00000185024 E041 53.825291 0.0006641686 0.6960560624 0.99995031 14 105252507 105252514 8 - 1.743 1.727 -0.056
ENSG00000185024 E042 77.844639 0.0058709937 0.2279484089 0.99995031 14 105252515 105252579 65 - 1.923 1.861 -0.211
ENSG00000185024 E043 35.284331 0.0008127785 0.0921666064 0.99995031 14 105256186 105256517 332 - 1.507 1.610 0.354
ENSG00000185024 E044 92.623800 0.0016290029 0.4392007623 0.99995031 14 105256518 105256549 32 - 1.983 1.954 -0.097
ENSG00000185024 E045 143.930119 0.0002927373 0.9663223831 0.99995031 14 105272721 105272894 174 - 2.158 2.162 0.013
ENSG00000185024 E046 81.413167 0.0004400640 0.9168310195 0.99995031 14 105286296 105286376 81 - 1.916 1.915 -0.005
ENSG00000185024 E047 96.368080 0.0051009024 0.0001538797 0.14488580 14 105300446 105301278 833 - 1.889 2.074 0.621
ENSG00000185024 E048 1.734188 0.0840146684 0.2170260403   14 105315322 105315341 20 - 0.300 0.554 1.375
ENSG00000185024 E049 2.742148 0.0145587224 0.7123304431 0.99995031 14 105315342 105315589 248 - 0.541 0.605 0.290