ENSG00000182899

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442341 ENSG00000182899 HEK293_DMSO_2hA HEK293_OSMI2_2hA RPL35A protein_coding protein_coding 728.0049 1052.93 899.8624 252.4866 238.5846 -0.2266311 30.45636 101.0323 31.70908 39.35184 9.411189 -1.67153663 0.03684583 0.0862000 0.0359000 -0.050300000 0.250731597 0.007671523 FALSE  
ENST00000448864 ENSG00000182899 HEK293_DMSO_2hA HEK293_OSMI2_2hA RPL35A protein_coding protein_coding 728.0049 1052.93 899.8624 252.4866 238.5846 -0.2266311 72.60702 106.0044 98.31470 20.15188 20.904885 -0.10863464 0.10217083 0.1046333 0.1143667 0.009733333 0.922957272 0.007671523 FALSE  
ENST00000485439 ENSG00000182899 HEK293_DMSO_2hA HEK293_OSMI2_2hA RPL35A protein_coding retained_intron 728.0049 1052.93 899.8624 252.4866 238.5846 -0.2266311 478.76359 613.1794 602.50088 138.18272 153.380359 -0.02534549 0.66535833 0.5886667 0.6722000 0.083533333 0.007671523 0.007671523 FALSE  
ENST00000647248 ENSG00000182899 HEK293_DMSO_2hA HEK293_OSMI2_2hA RPL35A protein_coding protein_coding 728.0049 1052.93 899.8624 252.4866 238.5846 -0.2266311 133.09121 220.4010 153.68411 56.85214 55.170100 -0.52013469 0.17575833 0.2071667 0.1607667 -0.046400000 0.498322938 0.007671523 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.