ENSG00000182054

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330062 ENSG00000182054 HEK293_DMSO_2hA HEK293_OSMI2_2hA IDH2 protein_coding protein_coding 89.19024 152.2841 164.1227 6.524351 5.658272 0.1080027 12.429140 23.851532 24.99045 1.473099 1.1581874 0.06726717 0.13320833 0.15656667 0.15230000 -0.004266667 0.9690034115 0.0002166283 FALSE  
ENST00000540499 ENSG00000182054 HEK293_DMSO_2hA HEK293_OSMI2_2hA IDH2 protein_coding protein_coding 89.19024 152.2841 164.1227 6.524351 5.658272 0.1080027 44.745717 68.004345 76.42920 2.851155 0.5427667 0.16847365 0.52433333 0.44680000 0.46680000 0.020000000 0.9229572715 0.0002166283 FALSE  
ENST00000560061 ENSG00000182054 HEK293_DMSO_2hA HEK293_OSMI2_2hA IDH2 protein_coding nonsense_mediated_decay 89.19024 152.2841 164.1227 6.524351 5.658272 0.1080027 6.247973 8.954334 17.25699 1.562322 1.8950227 0.94574842 0.07121667 0.05923333 0.10546667 0.046233333 0.2693214725 0.0002166283 FALSE  
MSTRG.11521.2 ENSG00000182054 HEK293_DMSO_2hA HEK293_OSMI2_2hA IDH2 protein_coding   89.19024 152.2841 164.1227 6.524351 5.658272 0.1080027 8.073680 22.484704 9.12832 1.054818 2.1815126 -1.29958446 0.07905833 0.14820000 0.05483333 -0.093366667 0.0002166283 0.0002166283 FALSE  
MSTRG.11521.6 ENSG00000182054 HEK293_DMSO_2hA HEK293_OSMI2_2hA IDH2 protein_coding   89.19024 152.2841 164.1227 6.524351 5.658272 0.1080027 17.353615 28.892850 35.68201 4.096562 3.1414161 0.30438951 0.18734583 0.18860000 0.21676667 0.028166667 0.9229572715 0.0002166283 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.