ENSG00000149091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421244 ENSG00000149091 HEK293_DMSO_2hA HEK293_OSMI2_2hA DGKZ protein_coding protein_coding 64.94069 88.7462 100.3731 10.89155 6.267193 0.1775963 32.969903 45.87595 54.59012 5.9401428 5.194741 0.2508517 0.4883708 0.5161333 0.54206667 0.02593333 0.92295727 0.04630573 FALSE TRUE
ENST00000456247 ENSG00000149091 HEK293_DMSO_2hA HEK293_OSMI2_2hA DGKZ protein_coding protein_coding 64.94069 88.7462 100.3731 10.89155 6.267193 0.1775963 6.044702 11.93799 7.31415 0.6678074 1.398015 -0.7060341 0.0917375 0.1380333 0.07193333 -0.06610000 0.04630573 0.04630573 FALSE TRUE
ENST00000529698 ENSG00000149091 HEK293_DMSO_2hA HEK293_OSMI2_2hA DGKZ protein_coding retained_intron 64.94069 88.7462 100.3731 10.89155 6.267193 0.1775963 9.333794 13.71620 15.94044 1.6149270 1.103095 0.2166644 0.1381667 0.1548333 0.15883333 0.00400000 0.96958316 0.04630573 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000149091 E001 0.2103315 0.0350126538 2.869201e-01   11 46332905 46333487 583 + 0.000 0.155 12.554
ENSG00000149091 E002 0.0000000       11 46338598 46338890 293 +      
ENSG00000149091 E003 0.1346978 0.0383181462 8.125193e-01   11 46345267 46345402 136 + 0.097 0.000 -11.725
ENSG00000149091 E004 0.1346978 0.0383181462 8.125193e-01   11 46345403 46345431 29 + 0.097 0.000 -11.725
ENSG00000149091 E005 0.1346978 0.0383181462 8.125193e-01   11 46345432 46345433 2 + 0.097 0.000 -11.725
ENSG00000149091 E006 0.1346978 0.0383181462 8.125193e-01   11 46345434 46345436 3 + 0.097 0.000 -11.725
ENSG00000149091 E007 0.3485050 0.0276090246 6.918024e-01   11 46345437 46345585 149 + 0.096 0.155 0.787
ENSG00000149091 E008 2.3774959 0.2251834557 9.141076e-02 0.99995031 11 46347463 46347510 48 + 0.296 0.690 1.999
ENSG00000149091 E009 1.9047857 0.3643886546 7.192549e-02 0.99995031 11 46347511 46347522 12 + 0.171 0.651 2.853
ENSG00000149091 E010 5.5746772 0.2894726654 2.597629e-02 0.93186675 11 46347523 46347556 34 + 0.391 1.043 2.781
ENSG00000149091 E011 16.2426588 0.0652467561 1.264057e-05 0.04193040 11 46347557 46347582 26 + 0.795 1.463 2.422
ENSG00000149091 E012 17.5110947 0.0511274457 1.625537e-06 0.01001897 11 46347583 46347587 5 + 0.829 1.494 2.394
ENSG00000149091 E013 174.0247214 0.0109810512 9.701246e-03 0.73196448 11 46347588 46347820 233 + 2.169 2.310 0.471
ENSG00000149091 E014 0.2138072 0.0373018931 2.864635e-01   11 46361522 46361605 84 + 0.000 0.155 12.634
ENSG00000149091 E015 0.2138072 0.0373018931 2.864635e-01   11 46361606 46361606 1 + 0.000 0.155 12.634
ENSG00000149091 E016 0.3485050 0.0276090246 6.918024e-01   11 46361607 46361706 100 + 0.096 0.155 0.787
ENSG00000149091 E017 0.4276143 0.5233587572 1.796969e-01   11 46361707 46361963 257 + 0.000 0.271 13.647
ENSG00000149091 E018 8.0379214 0.0464080544 2.667409e-01 0.99995031 11 46366244 46366526 283 + 0.863 1.034 0.641
ENSG00000149091 E019 8.6163257 0.0983581772 5.660415e-01 0.99995031 11 46366527 46366705 179 + 0.941 1.017 0.281
ENSG00000149091 E020 11.6791272 0.1027106084 9.933228e-01 0.99995031 11 46366706 46366984 279 + 1.113 1.082 -0.112
ENSG00000149091 E021 150.4312580 0.0032346162 7.853619e-01 0.99995031 11 46367291 46367314 24 + 2.174 2.184 0.032
ENSG00000149091 E022 268.9741656 0.0018392742 7.714266e-01 0.99995031 11 46367315 46367399 85 + 2.426 2.436 0.034
ENSG00000149091 E023 171.9691614 0.0017743653 3.681538e-01 0.99995031 11 46367652 46367654 3 + 2.252 2.224 -0.092
ENSG00000149091 E024 343.6748490 0.0003382017 4.438823e-01 0.99995031 11 46367655 46367747 93 + 2.543 2.530 -0.044
ENSG00000149091 E025 2.0728926 0.0089056570 9.007706e-01 0.99995031 11 46367748 46368001 254 + 0.475 0.498 0.110
ENSG00000149091 E026 126.8566978 0.0035904348 3.220588e-01 0.99995031 11 46368002 46368004 3 + 2.124 2.082 -0.140
ENSG00000149091 E027 310.2086026 0.0002892078 3.542293e-01 0.99995031 11 46368005 46368079 75 + 2.500 2.483 -0.057
ENSG00000149091 E028 33.2053176 0.0010518274 4.295083e-02 0.99995031 11 46368080 46369363 1284 + 1.464 1.593 0.441
ENSG00000149091 E029 11.6264531 0.0564754696 1.806048e-01 0.99995031 11 46369364 46369493 130 + 0.999 1.179 0.651
ENSG00000149091 E030 351.1459877 0.0007520100 6.644262e-01 0.99995031 11 46369494 46369550 57 + 2.549 2.542 -0.024
ENSG00000149091 E031 6.2884723 0.0813843802 6.639341e-01 0.99995031 11 46369551 46369940 390 + 0.819 0.895 0.290
ENSG00000149091 E032 385.1055908 0.0020815929 9.669406e-01 0.99995031 11 46369941 46370009 69 + 2.585 2.586 0.002
ENSG00000149091 E033 341.6722628 0.0048050645 9.589725e-01 0.99995031 11 46371313 46371384 72 + 2.535 2.533 -0.007
ENSG00000149091 E034 357.2737343 0.0013277325 7.409622e-01 0.99995031 11 46371487 46371603 117 + 2.556 2.549 -0.023
ENSG00000149091 E035 241.4364277 0.0005289694 1.301942e-01 0.99995031 11 46371704 46371724 21 + 2.399 2.363 -0.120
ENSG00000149091 E036 305.5753229 0.0002021989 3.020283e-01 0.99995031 11 46371725 46371775 51 + 2.494 2.475 -0.065
ENSG00000149091 E037 369.0559561 0.0011583615 4.012543e-01 0.99995031 11 46372075 46372170 96 + 2.578 2.557 -0.069
ENSG00000149091 E038 395.3568250 0.0002572171 3.102379e-02 0.95456446 11 46372428 46372510 83 + 2.615 2.576 -0.132
ENSG00000149091 E039 2.9380094 0.0064097818 1.080060e-01 0.99995031 11 46372511 46372616 106 + 0.697 0.434 -1.213
ENSG00000149091 E040 326.5284809 0.0009217650 8.319923e-01 0.99995031 11 46372617 46372677 61 + 2.516 2.513 -0.011
ENSG00000149091 E041 2.7646463 0.0083828590 4.006142e-01 0.99995031 11 46372678 46372770 93 + 0.510 0.647 0.618
ENSG00000149091 E042 380.9828796 0.0021783945 8.907730e-01 0.99995031 11 46372771 46372884 114 + 2.579 2.584 0.018
ENSG00000149091 E043 2.0760145 0.0108331324 6.544281e-02 0.99995031 11 46372885 46372897 13 + 0.601 0.269 -1.801
ENSG00000149091 E044 462.1257709 0.0005323641 6.932997e-01 0.99995031 11 46372961 46373101 141 + 2.668 2.662 -0.018
ENSG00000149091 E045 460.9963989 0.0002062496 7.970599e-01 0.99995031 11 46374157 46374235 79 + 2.660 2.667 0.022
ENSG00000149091 E046 400.0887784 0.0009993280 5.376287e-01 0.99995031 11 46374399 46374428 30 + 2.596 2.609 0.045
ENSG00000149091 E047 394.1848822 0.0002614201 9.704430e-01 0.99995031 11 46374429 46374454 26 + 2.594 2.595 0.004
ENSG00000149091 E048 500.1939725 0.0010859989 5.562306e-01 0.99995031 11 46374604 46374666 63 + 2.694 2.705 0.039
ENSG00000149091 E049 1.2325145 0.1804390912 3.265960e-01   11 46374667 46374765 99 + 0.244 0.434 1.192
ENSG00000149091 E050 572.6936799 0.0002382246 5.837181e-01 0.99995031 11 46374766 46374839 74 + 2.761 2.753 -0.025
ENSG00000149091 E051 579.7710923 0.0005621176 9.742618e-01 0.99995031 11 46374934 46375023 90 + 2.763 2.762 -0.002
ENSG00000149091 E052 279.6500139 0.0002709108 5.364225e-01 0.99995031 11 46375024 46375045 22 + 2.451 2.440 -0.039
ENSG00000149091 E053 644.1498710 0.0003338508 8.616608e-01 0.99995031 11 46375432 46375631 200 + 2.809 2.807 -0.005
ENSG00000149091 E054 517.7784908 0.0002181095 5.089548e-01 0.99995031 11 46375851 46375951 101 + 2.718 2.709 -0.029
ENSG00000149091 E055 438.5752995 0.0002318045 9.647933e-01 0.99995031 11 46376066 46376145 80 + 2.642 2.644 0.007
ENSG00000149091 E056 477.4271952 0.0002320141 3.974910e-01 0.99995031 11 46376328 46376397 70 + 2.685 2.672 -0.041
ENSG00000149091 E057 0.3782257 0.0295714068 2.078177e-01   11 46376520 46376523 4 + 0.242 0.000 -13.308
ENSG00000149091 E058 430.4201382 0.0027309177 9.493821e-01 0.99995031 11 46376524 46376564 41 + 2.633 2.636 0.009
ENSG00000149091 E059 4.6375935 0.0048893050 9.110025e-01 0.99995031 11 46376565 46377072 508 + 0.739 0.757 0.075
ENSG00000149091 E060 414.4451137 0.0043610492 6.600999e-01 0.99995031 11 46377073 46377147 75 + 2.624 2.613 -0.035
ENSG00000149091 E061 378.2430133 0.0038002160 5.619657e-01 0.99995031 11 46377148 46377212 65 + 2.587 2.569 -0.059
ENSG00000149091 E062 453.1188289 0.0031039248 8.751552e-01 0.99995031 11 46377213 46377967 755 + 2.661 2.653 -0.028
ENSG00000149091 E063 76.2440286 0.0186943394 7.743374e-01 0.99995031 11 46377968 46377969 2 + 1.906 1.871 -0.116
ENSG00000149091 E064 111.6544422 0.0123801040 6.793981e-01 0.99995031 11 46377970 46378197 228 + 2.069 2.034 -0.118
ENSG00000149091 E065 236.1014342 0.0019993247 9.897613e-01 0.99995031 11 46378198 46378229 32 + 2.373 2.378 0.016
ENSG00000149091 E066 17.2780389 0.0018541752 2.552752e-01 0.99995031 11 46378230 46378456 227 + 1.209 1.308 0.346
ENSG00000149091 E067 325.4946058 0.0009905188 7.827967e-01 0.99995031 11 46378457 46378500 44 + 2.516 2.513 -0.010
ENSG00000149091 E068 103.0437811 0.0061684076 4.768098e-01 0.99995031 11 46378501 46378893 393 + 1.995 2.042 0.160
ENSG00000149091 E069 54.5564510 0.0006064642 3.131305e-02 0.95648231 11 46378894 46378990 97 + 1.690 1.798 0.364
ENSG00000149091 E070 493.1886856 0.0001715987 3.199004e-01 0.99995031 11 46378991 46379111 121 + 2.683 2.703 0.065
ENSG00000149091 E071 364.0756125 0.0002261620 4.107575e-02 0.99742857 11 46379203 46379236 34 + 2.541 2.584 0.144
ENSG00000149091 E072 48.6029906 0.0063329981 7.754542e-01 0.99995031 11 46379237 46379453 217 + 1.687 1.706 0.062
ENSG00000149091 E073 22.1790289 0.0012329897 8.596597e-01 0.99995031 11 46379454 46379468 15 + 1.359 1.375 0.056
ENSG00000149091 E074 622.5089461 0.0017008566 7.499188e-01 0.99995031 11 46379469 46379568 100 + 2.792 2.797 0.015
ENSG00000149091 E075 391.3601390 0.0049894850 8.445360e-01 0.99995031 11 46379831 46379848 18 + 2.591 2.596 0.015
ENSG00000149091 E076 1252.0442161 0.0062626526 9.826013e-01 0.99995031 11 46379849 46380554 706 + 3.099 3.096 -0.009