ENSG00000008130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341426 ENSG00000008130 HEK293_DMSO_2hA HEK293_OSMI2_2hA NADK protein_coding protein_coding 63.83403 74.59187 83.54733 3.043258 3.242008 0.1635546 32.931015 51.791190 44.470618 2.2760750 4.645730 -0.2198084 0.4962083 0.69553333 0.5295333 -0.1660000000 3.079251e-02 1.836226e-05 FALSE TRUE
ENST00000341991 ENSG00000008130 HEK293_DMSO_2hA HEK293_OSMI2_2hA NADK protein_coding protein_coding 63.83403 74.59187 83.54733 3.043258 3.242008 0.1635546 8.296306 3.581663 17.052470 0.4480317 3.157008 2.2481025 0.1360000 0.04816667 0.2078333 0.1596666667 1.836226e-05 1.836226e-05 FALSE TRUE
MSTRG.115.5 ENSG00000008130 HEK293_DMSO_2hA HEK293_OSMI2_2hA NADK protein_coding   63.83403 74.59187 83.54733 3.043258 3.242008 0.1635546 6.419821 8.148332 9.106214 1.2895392 1.089738 0.1601606 0.1006000 0.10880000 0.1095667 0.0007666667 9.985435e-01 1.836226e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_2hA HEK293_DMSO_2hA log2fold_HEK293_DMSO_2hA_HEK293_OSMI2_2hA
ENSG00000008130 E001 728.0271469 0.0028217228 9.589842e-01 0.99995031 1 1751232 1752470 1239 - 2.860 2.864 0.012
ENSG00000008130 E002 1197.9807285 0.0001077452 2.578863e-01 0.99995031 1 1752471 1752974 504 - 3.083 3.074 -0.028
ENSG00000008130 E003 507.2390423 0.0005201857 6.253912e-01 0.99995031 1 1752975 1753060 86 - 2.709 2.704 -0.018
ENSG00000008130 E004 442.8026417 0.0003626312 5.546101e-01 0.99995031 1 1753567 1753649 83 - 2.652 2.644 -0.027
ENSG00000008130 E005 221.9846817 0.0010924733 5.073948e-01 0.99995031 1 1754051 1754060 10 - 2.356 2.340 -0.053
ENSG00000008130 E006 401.8065359 0.0002155227 1.903714e-01 0.99995031 1 1754061 1754162 102 - 2.614 2.593 -0.070
ENSG00000008130 E007 174.8575375 0.0002822032 4.126173e-02 0.99742857 1 1754163 1754164 2 - 2.269 2.216 -0.179
ENSG00000008130 E008 182.2209830 0.0002905709 4.465299e-02 0.99995031 1 1754165 1754170 6 - 2.286 2.235 -0.173
ENSG00000008130 E009 195.8284414 0.0003100729 1.289819e-01 0.99995031 1 1754171 1754180 10 - 2.310 2.273 -0.124
ENSG00000008130 E010 237.2414615 0.0006286032 1.797409e-01 0.99995031 1 1754181 1754202 22 - 2.391 2.359 -0.105
ENSG00000008130 E011 216.6925500 0.0008900757 2.712396e-01 0.99995031 1 1754203 1754208 6 - 2.349 2.322 -0.092
ENSG00000008130 E012 23.2681931 0.0097175969 3.289225e-02 0.96518378 1 1754209 1754283 75 - 1.459 1.278 -0.629
ENSG00000008130 E013 413.8140179 0.0003021587 6.155751e-01 0.99995031 1 1754284 1754342 59 - 2.612 2.625 0.044
ENSG00000008130 E014 384.2586992 0.0005908692 1.579436e-01 0.99995031 1 1754343 1754383 41 - 2.571 2.604 0.110
ENSG00000008130 E015 625.5610243 0.0011917867 4.640258e-01 0.99995031 1 1754544 1754698 155 - 2.803 2.791 -0.038
ENSG00000008130 E016 23.6503235 0.0011671439 1.807820e-01 0.99995031 1 1754699 1754896 198 - 1.341 1.441 0.346
ENSG00000008130 E017 474.5141950 0.0007935193 6.438967e-01 0.99995031 1 1755374 1755476 103 - 2.681 2.675 -0.020
ENSG00000008130 E018 20.0350720 0.0013710663 7.343455e-01 0.99995031 1 1756004 1756257 254 - 1.331 1.307 -0.082
ENSG00000008130 E019 390.4758788 0.0002025778 6.950363e-01 0.99995031 1 1756258 1756343 86 - 2.595 2.591 -0.013
ENSG00000008130 E020 372.2870066 0.0002854026 6.289123e-01 0.99995031 1 1756503 1756587 85 - 2.564 2.577 0.044
ENSG00000008130 E021 230.7829150 0.0002307414 6.987415e-01 0.99995031 1 1756588 1756608 21 - 2.358 2.371 0.043
ENSG00000008130 E022 6.4616594 0.0150983900 6.381669e-02 0.99995031 1 1756609 1756657 49 - 0.976 0.723 -0.983
ENSG00000008130 E023 7.0844182 0.0029003615 1.403877e-02 0.81157952 1 1756658 1756738 81 - 1.030 0.723 -1.179
ENSG00000008130 E024 6.3476174 0.0890625530 1.746809e-01 0.99995031 1 1756739 1756770 32 - 0.965 0.724 -0.935
ENSG00000008130 E025 4.9709186 0.1350164106 4.179772e-01 0.99995031 1 1756771 1756778 8 - 0.845 0.686 -0.638
ENSG00000008130 E026 13.0237545 0.0162009741 7.530384e-01 0.99995031 1 1756779 1756882 104 - 1.161 1.128 -0.116
ENSG00000008130 E027 11.0971779 0.0180018550 9.552583e-01 0.99995031 1 1756883 1757106 224 - 1.086 1.084 -0.009
ENSG00000008130 E028 4.6435200 0.0669587935 1.845663e-01 0.99995031 1 1757107 1757180 74 - 0.625 0.868 0.990
ENSG00000008130 E029 454.1370900 0.0002518698 2.970370e-01 0.99995031 1 1757181 1757310 130 - 2.647 2.669 0.074
ENSG00000008130 E030 6.3474638 0.0996455164 5.600720e-01 0.99995031 1 1758365 1758575 211 - 0.811 0.919 0.415
ENSG00000008130 E031 2.2837249 0.0079507831 7.741334e-01 0.99995031 1 1759101 1759243 143 - 0.543 0.497 -0.216
ENSG00000008130 E032 3.6351839 0.0068558097 4.372120e-01 0.99995031 1 1759734 1759902 169 - 0.718 0.602 -0.494
ENSG00000008130 E033 6.9739937 0.0456274580 9.073060e-01 0.99995031 1 1761665 1761951 287 - 0.904 0.895 -0.037
ENSG00000008130 E034 392.0456472 0.0002988911 2.662658e-01 0.99995031 1 1761952 1762035 84 - 2.581 2.606 0.083
ENSG00000008130 E035 448.2304131 0.0012289512 2.377012e-03 0.47007308 1 1765228 1765446 219 - 2.614 2.688 0.247
ENSG00000008130 E036 129.8139247 0.0141621326 2.140972e-05 0.05336209 1 1778289 1778470 182 - 1.955 2.240 0.956
ENSG00000008130 E037 5.5984058 0.0107846220 9.386602e-01 0.99995031 1 1778746 1778867 122 - 0.827 0.818 -0.034
ENSG00000008130 E038 0.2138072 0.0362043279 2.906465e-01   1 1779157 1779196 40 - 0.000 0.155 10.761
ENSG00000008130 E039 0.1088301 0.0385945388 7.915675e-01   1 1779905 1780029 125 - 0.096 0.000 -10.618
ENSG00000008130 E040 0.0000000       1 1780030 1780069 40 -      
ENSG00000008130 E041 0.1346978 0.0390640894 7.902781e-01   1 1780282 1780457 176 - 0.097 0.000 -10.611